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View Structure Prediction Details

Protein: gi|2827203, gi|1...
Organism: Homo sapiens
Length: 978 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2827203, gi|1....

Description E-value Query
Range
Subject
Range
gi|114614019 - gi|114614019|ref|XP_001151693.1| PREDICTED: general transcription factor II, i isoform 8 [Pan troglo...
0.0 [1..978] [1..978]
gi|73957635, gi|... - gi|73957635|ref|XP_856663.1| PREDICTED: similar to general transcription factor II, i isoform 2 isof...
0.0 [1..978] [1..979]
GTF2I - general transcription factor II, i
0.0 [1..978] [1..998]
gi|17223644, gi|... - gi|17223644|gb|AAK49786.1| transcription factor TFII-I-beta [Mus musculus], gi|148687504|gb|EDL19451...
0.0 [1..978] [1..979]
gi|76653756 - gi|76653756|ref|XP_886987.1| PREDICTED: similar to general transcription factor II, i isoform 2 isof...
0.0 [1..978] [1..979]
GTF2I_RAT - General transcription factor II-I OS=Rattus norvegicus GN=Gtf2i PE=1 SV=2
0.0 [1..978] [1..979]

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Predicted Domain #1
Region A:
Residues: [1-18]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVAMSTLP VEDEESSE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [19-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMVVTFLMS ALESMCKELA KSKAEVACIA VYETDVFVVG TERGRAFVNT RKDFQKDFVK  60
   61 YCVEEEEKAA EMHKMKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.653 N/A N/A d.88.1 SRF-like
View Download 0.645 N/A N/A d.88.1 SRF-like
View Download 0.619 N/A N/A d.88.1 SRF-like
View Download 0.618 N/A N/A d.88.1 SRF-like
View Download 0.617 N/A N/A d.88.1 SRF-like

Predicted Domain #3
Region A:
Residues: [96-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTQANRMSVD AVEIETLRKT VEDYFCFCYG KALGKSTVVP VPYEKMLRDQ SAVVVQGLPE  60
   61 GVAFKHPENY DLATLKWILE NKAGISFIIK RPFLEPKKHV G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.045757
Match: 2d9bA
Description: No description for 2d9bA was found.

Predicted Domain #4
Region A:
Residues: [197-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRVMVTDADR SILSPGGSCG PIKVKTEPTE DSGISLEMAA VTVKEESEDP DYYQYNIQGS  60
   61 HHSSEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [263-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEGTEMEVPA EDSTQHVPSE TSEDPEVEVT IEDDDYSPPS KRPKANELPQ PPVPEPANAG  60
   61 KRKVREFNFE KWNARITDLR KQVEELFERK YAQAIKAKGP VTIPYPLFQS HVEDLYVEGL 120
  121 PEGIPFRRPS TYGIPRLERI LLAKERIRFV IKKHELLNST REDLQLDKPA SGVKEEWYAR 180
  181 ITKLRKMVDQ LFCKKFAEAL GSTEAKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 2dn4A
Description: No description for 2dn4A was found.

Predicted Domain #6
Region A:
Residues: [470-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT  60
   61 EVTQPRTNTP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.310 c.23.1 CheY-like
View Download 0.439 d.58.5 GlnB-like
View Download 0.286 c.31.1 DHS-like NAD/FAD-binding domain
View Download 0.273 d.109.1 Actin depolymerizing proteins
View Download 0.283 c.52.2 tRNA splicing endonuclease, C-terminal domain

Predicted Domain #7
Region A:
Residues: [540-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR  60
   61 SPTWFGIPRL ERIVRGSNKI KFVVKKPELV ISYLPPGMAS KINTKALQSP KRPRSPGSNS 120
  121 KVPEIEVTVE GPNNNNPQTS AVRTPTQTNG SNVPFKPRGR EFSFEA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.59
Match: 2ed2A
Description: No description for 2ed2A was found.

Predicted Domain #8
Region A:
Residues: [706-804]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNAKITDLKQ KVENLFNEKC GEALGLKQAV KVPFALFESF PEDFYVEGLP EGVPFRRPST  60
   61 FGIPRLEKIL RNKAKIKFII KKPEMFETAI KESTSSKSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.154902
Match: 1q60A
Description: Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.31986990828723 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 4.02258915980722 bayes_pls_golite062009
DNA binding 4.01598187073916 bayes_pls_golite062009
nucleic acid binding 3.9329721501879 bayes_pls_golite062009
transcription factor activity 3.83217404681534 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.76277877142766 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.91960306002172 bayes_pls_golite062009
mitogen-activated protein kinase binding 0.245342655759921 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [805-978]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRKINSSPNV NTTASGVEDL NIIQVTIPDD DNERLSKVEK ARQLREQVND LFSRKFGEAI  60
   61 GMGFPVKVPY RKITINPGCV VVDGMPPGVS FKAPSYLEIS SMRRILDSAE FIKFTVIRPF 120
  121 PGLVINNQLV DQSESEGPVI QESAEPSQLE VPATEEIKET DGSSQIKQEP DPTW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 2ejeA
Description: No description for 2ejeA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle