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View Structure Prediction Details

Protein: KHDRBS1
Organism: Homo sapiens
Length: 443 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KHDRBS1.

Description E-value Query
Range
Subject
Range
KHDR1_RAT - KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Rattus norvegicus GN=...
0.0 [1..443] [1..443]
KHDR1_MOUSE - KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Mus musculus GN=Khdrb...
0.0 [1..443] [1..443]
gi|67971968 - gi|67971968|dbj|BAE02326.1| unnamed protein product [Macaca fascicularis]
0.0 [1..443] [1..443]
gi|88954299, gi|... - gi|88954299|gb|AAI14076.1| KH domain containing, RNA binding, signal transduction associated 1 [Bos ...
0.0 [1..443] [1..443]
gi|21749696 - gi|21749696|dbj|BAC03643.1| unnamed protein product [Homo sapiens]
0.0 [1..443] [1..418]
gi|114555300 - gi|114555300|ref|XP_513273.2| PREDICTED: similar to p62 [Pan troglodytes]
0.0 [1..443] [205..641]
gi|73950011 - gi|73950011|ref|XP_864860.1| PREDICTED: similar to KH domain containing, RNA binding, signal transdu...
0.0 [21..443] [1..405]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRRDDPAAR MSRSSGRSGS MDPSGAHPSV RQTPSRQPPL PHRSRGGGGG SRGGARASPA  60
   61 TQPPPLLPPS ATGPDATVGG PAPTPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [87-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPSATASVK MEPENKYLPE LMAEKDSLDP SFTHAMQLLT AEIEKIQKG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [136-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSKKDDEENY LDLFSHKNMK LKERVLIPVK QYPKFNFVGK ILGPQGNTIK RLQEETGAKI  60
   61 SVLGKGSMRD KAKEEELRKG GDPKYAHLNM DLHVFIEVFG PPCEAYALMA HAMEEVKKFL 120
  121 VPDMMDDICQ EQFLELSYLN GVPEPSRGRG VPVRGRGAAP PP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 2bl5A
Description: Solution structure of the KH-QUA2 region of the Xenopus STAR-GSG Quaking protein.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
nucleic acid binding 4.48152042822746 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.54125642939085 bayes_pls_golite062009
DNA binding 2.21410605855315 bayes_pls_golite062009
transcription repressor activity 2.05847856402521 bayes_pls_golite062009
transcription factor activity 1.22994056525688 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
0.800987648548054 bayes_pls_golite062009
signal transducer activity 0.770583526648683 bayes_pls_golite062009
molecular transducer activity 0.770583526648683 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription activator activity 0.404927707462702 bayes_pls_golite062009
poly-pyrimidine tract binding 0.30467150200016 bayes_pls_golite062009
transcription factor binding 0.274119533759015 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [298-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVPRGRGVG PPRGALVRGT PVRGAITRGA TVTRGVPPPP TVRGAPAPRA RTAGIQRIPL  60
   61 PPPPAPETYE EYGYDDTYAE QSYEGYEGYY SQSQGDSEYY DYGHGEVQDS YEAYGQDDWN 120
  121 GTRPSLKAPP ARPVKGAYRE HPYGRY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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