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View Structure Prediction Details

Protein: PBX4
Organism: Homo sapiens
Length: 374 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PBX4.

Description E-value Query
Range
Subject
Range
gi|73986028 - gi|73986028|ref|XP_852080.1| PREDICTED: similar to pre-B-cell leukemia transcription factor 4 [Canis...
7.0E-54 [18..374] [32..388]
gi|114676282 - gi|114676282|ref|XP_001137150.1| PREDICTED: similar to pre-B-cell leukemia transcription factor 4 [P...
1.0E-52 [40..374] [10..344]
PBX4 - pre-B-cell leukemia homeobox 4
9.0E-52 [45..374] [1..330]
gi|74198121 - gi|74198121|dbj|BAE35238.1| unnamed protein product [Mus musculus]
4.0E-50 [17..374] [51..430]
gi|109469601 - gi|109469601|ref|XP_001078743.1| PREDICTED: similar to Pre-B-cell leukemia transcription factor 3 (H...
1.0E-49 [1..374] [25..427]

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Predicted Domain #1
Region A:
Residues: [1-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK PALFSVLCEI  60
   61 KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG RGGAVARAGT ATPGGCPNDN 120
  121 SIEHSDYRAK LSQIRQIYHS ELEKYEQACR EFTTHVTNLL QEQSRMRPVS PKEIERMVGA 180
  181 IHGKFSAIQM QLKQSTCEAV MTLRSRLL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 117.638272
Match: PF03792.4
Description: No description for PF03792.4 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [209-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DARRKRRNFS KQATEVLNEY FYSHLNNPYP SEEAKEELAR KGGLTISQVS NWFGNKRIRY  60
   61 KKNMGKFQEE ATIYTGKTAV DTTEVGVPGN HASCLSTPSS GSSGPFPLPS AGDAFLTLRT 120
  121 LASLQPPPGG GCLQSQAQGS WQGATPQPAT ASPAGDPGSI NSSTSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1b72B
Description: pbx1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle