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View Structure Prediction Details

Protein: NFYC
Organism: Homo sapiens
Length: 458 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFYC.

Description E-value Query
Range
Subject
Range
gi|114556065 - gi|114556065|ref|XP_513359.2| PREDICTED: similar to NFY-C variant DS2.8 [Pan troglodytes]
0.0 [1..458] [105..562]
gi|109003238 - gi|109003238|ref|XP_001084934.1| PREDICTED: similar to Nuclear transcription factor Y subunit gamma ...
0.0 [1..437] [1..418]
gi|55958370, gi|... - gi|7020370|dbj|BAA91100.1| unnamed protein product [Homo sapiens], gi|55958370|emb|CAI16530.1| nucle...
0.0 [1..458] [1..439]
gi|50759806 - gi|50759806|ref|XP_417790.1| PREDICTED: similar to Nuclear transcription factor Y subunit gamma (NF-...
2.0E-84 [1..351] [543..868]
gi|77736143, gi|... - gi|77736143|ref|NP_001029770.1| nuclear transcription factor Y, gamma [Bos taurus], gi|59857849|gb|A...
2.0E-77 [1..351] [1..332]
gi|51766794, gi|... - gi|94393798|ref|XP_996565.1| PREDICTED: similar to Nuclear transcription factor Y subunit gamma (Nuc...
5.0E-77 [1..351] [1..333]
gi|2143652 - gi|2143652|pir||I59348 CCAAT binding transcription factor CBF subunit C - rat
8.0E-77 [1..351] [1..332]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM  60
   61 ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR 120
  121 DELKPPKRQE E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1n1jB
Description: Nuclear transcription factor Y subunit gamma (Nf-Yc2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 4.8544267677131 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
transcription initiation factor activity 0.0945459819298291 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009
transcription corepressor activity 0.0736756545988504 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [132-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRQSVTPAEP VQYYFTLAQQ PTAVQVQGQQ QGQQTTSSTT TIQPGQIIIA QPQQGQTTPV  60
   61 TMQVGEGQQV QIVQAQPQGQ AQQAQSGTGQ TMQVMQQIIT NT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [234-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEIQQIPVQL NAGQLQYIRL AQPVSGTQVV QGQIQTLATN AQQGQRNASQ GKPRRCLKET  60
   61 LQITQTEVQQ GQQQFSQFT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [313-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGQRNSVQQA RVSELTGEAE PREVKATGNS TPCTSSLPTT HPPSHRAGAS CVCCSQPQQS  60
   61 STSPPPSDAL QWVVVEVSGT PNQLETHREL HAPLPGMTSL SPLHPSQQLY QIQQVTMPAG 120
  121 QDLAQPMFIQ SANQPSDGQA PQVTGD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle