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View Structure Prediction Details

Protein: SOX10
Organism: Homo sapiens
Length: 466 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOX10.

Description E-value Query
Range
Subject
Range
gi|73969678 - gi|73969678|ref|XP_538379.2| PREDICTED: similar to SRY (sex determining region Y)-box 10 [Canis fami...
3.0E-59 [1..466] [154..621]
gi|148672721, gi... - gi|94399600|ref|XP_001001504.1| PREDICTED: similar to Transcription factor SOX-10 (SOX-21) (Transcri...
2.0E-58 [1..466] [104..569]
gi|60653343 - gi|60653343|gb|AAX29366.1| SRY-box 10 [synthetic construct]
2.0E-54 [1..466] [1..466]
SOX10_RAT - Transcription factor SOX-10 OS=Rattus norvegicus GN=Sox10 PE=1 SV=1
2.0E-54 [1..466] [1..466]
gi|49168626 - gi|49168626|emb|CAG38808.1| SOX10 [Homo sapiens]
8.0E-54 [1..466] [1..466]
gi|76616743 - gi|76616743|ref|XP_884266.1| PREDICTED: similar to SRY (sex determining region Y)-box 10 isoform 4 [...
1.0E-53 [1..466] [1..471]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD  60
   61 GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR 120
  121 KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN 180
  181 GKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.30103
Match: 2gzkA
Description: No description for 2gzkA was found.

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
nucleic acid binding 5.01228762819617 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
sequence-specific DNA binding 4.06355503548774 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
transcription activator activity 2.95665802871704 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.75319687398598 bayes_pls_golite062009
protein binding 2.18211240370246 bayes_pls_golite062009
chromatin binding 1.64428658020027 bayes_pls_golite062009
transcription repressor activity 1.53825678633232 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.261169200304829 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [184-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQGEAECPGG EAEQGGTAAI QAHYKSAHLD HRHPGEGSPM SDGNPEHPSG QSHGPPTPPT  60
   61 TPKTELQSGK ADPKRDGRSM GEGGKPHIDF GNVDIGEISH EVMSNMETFD VAELDQYLPP 120
  121 NGHPGHVSSY SAAGYGLGSA LAVASGHSAW ISKPPGVALP TVSPPGVDAK 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.1
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [354-466]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQVKTETAGP QGPPHYTDQP STSQIAYTSL SLPHYGSAFP SISRPQFDYS DHQPSGPYYG  60
   61 HSGQASGLYS AFSYMGPSQR PLYTAISDPS PSGPQSHSPT HWEQPVYTTL SRP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle