YRC Public Data Repository - Protein Structure Prediction

Protein:	CD69
Organism:	Homo sapiens
Length:	199 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CD69.

Description	E-value	Query Range	Subject Range
gi\|148744280, gi... - gi\|27806705\|ref\|NP_776439.1\| CD69 antigen (p60, early T-cell activation antigen) [Bos taurus], gi\|14...	3.0E-36	[1..199]	[1..199]
gi\|19550842, gi\|... - gi\|47522992\|ref\|NP_999256.1\| CD69 antigen (p60, early T-cell activation antigen) [Sus scrofa], gi\|19...	1.0E-34	[1..196]	[1..197]
CLC4M_SYMSY - C-type lectin domain family 4 member M OS=Symphalangus syndactylus GN=CLEC4M PE=3 SV=1	2.0E-34	[4..198]	[202..416]
gi\|61097910, gi\|... - gi\|61097910\|ref\|NP_599154.1\| Cd69 molecule [Rattus norvegicus], gi\|56789283\|gb\|AAH88219.1\| Cd69 mole...	4.0E-34	[1..196]	[1..196]
gi\|114643484 - gi\|114643484\|ref\|XP_520732.2\| PREDICTED: CD69 antigen (p60, early T-cell activation antigen) [Pan tr...	5.0E-34	[1..199]	[1..199]
CLC4M_HYLLA - C-type lectin domain family 4 member M OS=Hylobates lar GN=CLEC4M PE=3 SV=1	5.0E-33	[3..197]	[178..392]
gi\|123994207 - gi\|123994207\|gb\|ABM84705.1\| C-type lectin domain family 4, member M [synthetic construct] CLEC4M - C-type lectin domain family 4, member M	6.0E-33	[4..197]	[179..392]
gi\|109095584 - gi\|109095584\|ref\|XP_001114683.1\| PREDICTED: similar to CD69 antigen (p60, early T-cell activation an...	6.0E-33	[1..199]	[1..199]
CLC4M_NOMCO - C-type lectin domain family 4 member M OS=Nomascus concolor GN=CLEC4M PE=3 SV=1	9.0E-33	[3..197]	[178..392]
CD69_MOUSE - Early activation antigen CD69 OS=Mus musculus GN=Cd69 PE=2 SV=1	9.0E-33	[1..197]	[1..197]

Back

Predicted Domain #1

Region A:
Residues: [1-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF ITILIIALIA  60
   61 LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS TVKRSWTSAQ NACSEHGATL 120
  121 AVIDSEKDMN FLKRYAGREE HWVGLKKEPG HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE 180
  181 VSSMECEKNL YWICNKPYK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.30103
Match:	1fm5A
Description:	CD69
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor activity	3.98996960244405	bayes_pls_golite062009
transmembrane receptor activity	3.91893667918626	bayes_pls_golite062009
monosaccharide binding	3.11313573656236	bayes_pls_golite062009
molecular transducer activity	3.03592595048581	bayes_pls_golite062009
signal transducer activity	3.03592595048581	bayes_pls_golite062009
carbohydrate binding	2.63424321036563	bayes_pls_golite062009
hyaluronic acid binding	2.24101091318298	bayes_pls_golite062009
binding	2.03451078500546	bayes_pls_golite062009
mannose binding	2.02769829616516	bayes_pls_golite062009
polysaccharide binding	2.00647699969727	bayes_pls_golite062009
pattern binding	1.93929977823971	bayes_pls_golite062009
fucose binding	1.84048523146965	bayes_pls_golite062009
glycosaminoglycan binding	1.74017863387581	bayes_pls_golite062009
antigen binding	1.69692361913389	bayes_pls_golite062009
peptide antigen binding	1.21587238898951	bayes_pls_golite062009
receptor binding	1.20879764002314	bayes_pls_golite062009
sugar binding	1.08373701017943	bayes_pls_golite062009
calcium-dependent protein binding	1.03810546168048	bayes_pls_golite062009
MHC class Ib receptor activity	0.943014275506551	bayes_pls_golite062009
zymosan receptor activity	0.943014275506551	bayes_pls_golite062009
polysaccharide receptor activity	0.943014275506551	bayes_pls_golite062009
protein binding	0.878161674100774	bayes_pls_golite062009
cell surface binding	0.847091868125047	bayes_pls_golite062009
natural killer cell receptor activity	0.726020405011931	bayes_pls_golite062009
	0.683342783917951	bayes_pls_golite062009
calcium ion binding	0.409714138901478	bayes_pls_golite062009
sialic acid binding	0.320555870924401	bayes_pls_golite062009
eukaryotic cell surface binding	0.21157949111795	bayes_pls_golite062009
natural killer cell lectin-like receptor binding	0.204348795793981	bayes_pls_golite062009
catalytic activity	0.10160549859022	bayes_pls_golite062009
growth factor binding	0.0425815687857338	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: