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View Structure Prediction Details

Protein: TIGD1
Organism: Homo sapiens
Length: 591 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIGD1.

Description E-value Query
Range
Subject
Range
gi|114583892 - gi|114583892|ref|XP_001146675.1| PREDICTED: hypothetical protein [Pan troglodytes]
0.0 [1..591] [1..591]
gi|109101484 - gi|109101484|ref|XP_001114170.1| PREDICTED: similar to Jerky protein [Macaca mulatta]
0.0 [1..591] [1..591]
gi|39645795 - gi|39645795|gb|AAH63500.1| Unknown (protein for MGC:74576) [Homo sapiens]
0.0 [23..591] [1..569]
gi|57110705 - gi|57110705|ref|XP_535991.1| PREDICTED: similar to tigger transposable element derived 1 [Canis fami...
0.0 [1..591] [1..591]
gi|34860486, gi|... - gi|34860486|ref|XP_235818.2| PREDICTED: similar to jerky homolog-like [Rattus norvegicus], gi|157822...
0.0 [7..538] [2..517]
JERKL_MOUSE - Jerky protein homolog-like OS=Mus musculus GN=Jrkl PE=2 SV=1
0.0 [7..538] [2..516]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV VNAKEKFLKE  60
   61 VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL SQSLIQNKAL TLFNSMKAER 120
  121 GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA QGEAASA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1hlvA
Description: DNA-binding domain of centromere binding protein B (CENP-B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.71840976776163 bayes_pls_golite062009
DNA binding 2.61711182194361 bayes_pls_golite062009
binding 2.59102816487173 bayes_pls_golite062009
nucleic acid binding 2.3237599869447 bayes_pls_golite062009
transcription factor activity 2.18905180070231 bayes_pls_golite062009
sequence-specific DNA binding 1.69885241317809 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.35613772918036 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
transcription activator activity 0.67940033960016 bayes_pls_golite062009
transcription repressor activity 0.67392957114349 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.44172618015361 bayes_pls_golite062009
transcription factor binding 0.22865859991459 bayes_pls_golite062009
chromatin binding 0.203837749053719 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVEAAASYPE ALAKIIDEGG YTKQQIFNVD ETAFYWKKMP SRTFIAREEK SVPGFKASKD  60
   61 RLTLLLGANA AGDFKLKPML IYHSENPRAL KNYTKSTLPV LYKWNSKARM TAHLFTAWFT 120
  121 EYFKPTVETY CSEKKIPFKI LLLIDNAPSH PRALMEIYEE INVIFMPANT TSILQPMDQG 180
  181 VISTFKSYYL RNTFHKALAA MDSDVSDGSG QSKLKTFWKG FTILDAIKNI RDSWEEVKLS 240
  241 TLTGVWKKLI PTLIDDYEGF KT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.52
Match: 2f7tA
Description: No description for 2f7tA was found.

Predicted Domain #3
Region A:
Residues: [420-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVEEVSADVV EIAKELELEV EPEDVTELLQ SHDKTLTDEE LFLMDAQRKW FLEMESTPGE  60
   61 DAVNIVEMTT KDLEYYINLV DKAAAGFERI DSNFERSSTV GKMLSNSIAC YREIFHERKS 120
  121 QLMRKASPMS YFRKLPQPPQ PSAATTLTSQ QPSTSRQDPP PAKRVRLTEG SD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle