YRC Public Data Repository - Protein Structure Prediction

Protein:	CCT6A
Organism:	Homo sapiens
Length:	531 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCT6A.

Description	E-value	Query Range	Subject Range
gi\|116754081, gi... - gi\|88950858\|ref\|ZP_01153432.1\| Chaperonin Cpn60/TCP-1 [Methanosaeta thermophila PT], gi\|88930057\|gb\|...	0.0	[2..525]	[7..522]
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	0.0	[2..526]	[7..526]
gi\|11277150, gi\|... - gi\|3218368\|emb\|CAA07096.1\| ThsB [Pyrodictium occultum], pir\|\|T45139 chaperone protein thsB [imported...	0.0	[3..527]	[22..556]
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus GN=thsB PE=3 SV=1 THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 /...	0.0	[2..525]	[7..525]
THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=ths PE=3 SV=1 THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi GN=ths PE=3 SV=1	0.0	[2..526]	[7..526]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2 THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2	0.0	[2..531]	[7..533]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1 THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths... gi\|473965, gi\|21... - gi\|473965\|dbj\|BAA06143.1\| heat-shock protein [Pyrococcus sp.], pir\|\|S61294 heat-shock protein - Pyro...	0.0	[2..531]	[7..533]
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139... THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii GN=ths PE=3 SV=1	0.0	[2..524]	[7..524]
gi\|30908966 - gi\|30908966\|gb\|AAP37564.1\| thermosome alpha subunit [Thermococcus litoralis]	0.0	[2..524]	[7..524]
gi\|110554018, gi... - gi\|119719209\|ref\|YP_919704.1\| thermosome [Thermofilum pendens Hrk 5], gi\|119524329\|gb\|ABL77701.1\| th...	0.0	[3..526]	[7..525]

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Predicted Domain #1

Region A:
Residues: [1-531]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG  60
   61 NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 120
  121 EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK 180
  181 KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE 240
  241 KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF 300
  301 SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF 360
  361 TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE 420
  421 ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD 480
  481 LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	149.0
Match:	1q3rA
Description:	Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	2.03574683256805	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: