YRC Public Data Repository - Protein Structure Prediction

Protein:	PDA1
Organism:	Saccharomyces cerevisiae
Length:	420 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDA1.

Description	E-value	Query Range	Subject Range
PDA1 - E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarbo... gi\|151944896 - gi\|151944896\|gb\|EDN63155.1\| pyruvate dehydrogenase alpha subunit (E1 alpha) [Saccharomyces cerevisia... ODPA_YEAST - Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Saccharomyces cerevisiae (strain... gi\|190405734 - gi\|190405734\|gb\|EDV09001.1\| pyruvate dehydrogenase alpha subunit [Saccharomyces cerevisiae RM11-1a]	3.0E-96	[1..417]	[1..417]
gi\|45201199, gi\|... - gi\|45201199\|ref\|NP_986769.1\| AGR103Wp [Ashbya gossypii ATCC 10895], gi\|44986053\|gb\|AAS54593.1\| AGR10... gi\|44986053 - gi\|44986053\|gb\|AAS54593.1\| AGR103Wp [Ashbya gossypii ATCC 10895]	1.0E-82	[13..420]	[1..408]
gi\|49095676, gi\|... - gi\|67537984\|ref\|XP_662766.1\| hypothetical protein AN5162.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	1.0E-80	[6..403]	[3..397]
ODPA_MOUSE - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus GN=Pd...	8.0E-80	[13..405]	[4..382]
gi\|66267554, gi\|... - gi\|66267554\|gb\|AAH94760.1\| PDHA2 protein [Homo sapiens], gi\|34192185\|gb\|AAH30697.2\| PDHA2 protein [H...	2.0E-79	[11..392]	[19..387]
gi\|34879653 - gi\|34879653\|ref\|XP_225052.2\| PREDICTED: similar to pyruvate dehydrogenase [Rattus norvegicus]	1.0E-78	[13..405]	[4..382]

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Predicted Domain #1

Region A:
Residues: [1-420]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAASFKRQP SQLVRGLGAV LRTPTRIGHV RTMATLKTTD KKAPEDIEGS DTVQIELPES  60
   61 SFESYMLEPP DLSYETSKAT LLQMYKDMVI IRRMEMACDA LYKAKKIRGF CHLSVGQEAI 120
  121 AVGIENAITK LDSIITSYRC HGFTFMRGAS VKAVLAELMG RRAGVSYGKG GSMHLYAPGF 180
  181 YGGNGIVGAQ VPLGAGLAFA HQYKNEDACS FTLYGDGASN QGQVFESFNM AKLWNLPVVF 240
  241 CCENNKYGMG TAASRSSAMT EYFKRGQYIP GLKVNGMDIL AVYQASKFAK DWCLSGKGPL 300
  301 VLEYETYRYG GHSMSDPGTT YRTRDEIQHM RSKNDPIAGL KMHLIDLGIA TEAEVKAYDK 360
  361 SARKYVDEQV ELADAAPPPE AKLSILFEDV YVKGTETPTL RGRIPEDTWD FKKQGFASRD 420
  421

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.30103
Match:	1ni4A_
Description:	E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.58421424158131	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: