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View Structure Prediction Details

Protein: SRO9
Organism: Saccharomyces cerevisiae
Length: 434 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRO9.

Description E-value Query
Range
Subject
Range
SRO9 - Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulat...
gi|207347365 - gi|207347365|gb|EDZ73559.1| YCL037Cp-like protein [Saccharomyces cerevisiae AWRI1631]
2.0E-47 [1..434] [33..466]
gi|3882183 - gi|3882183|dbj|BAA34451.1| KIAA0731 protein [Homo sapiens]
3.0E-41 [6..408] [137..536]
gi|7506734 - gi|7506734|pir||T16754 hypothetical protein R144.7 - Caenorhabditis elegans
5.0E-35 [17..349] [297..606]
gi|26345616 - gi|26345616|dbj|BAC36459.1| unnamed protein product [Mus musculus]
2.0E-32 [67..372] [2..321]

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Predicted Domain #1
Region A:
Residues: [1-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAETAAANT ATAPVPEVQE QESSKSKQVN LTPAPLPTSS PWKLAPTEIP VSTISIEDLD  60
   61 ATRKKKNRTP TPKSSTATKW VPIKASITVS GTKRSGSKNG ASNGNSNKSK NNKTAASSTS 120
  121 SSNANRKKKH HQHNAKKQQQ MKKDGFESAV GEEDSKDATS QENGQSTQQQ QPPHHRNHHH 180
  181 SHHHNSNGPQ RRKFHNSNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [200-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGMPQNQGFP PQFKPYQGRN ARNNNNNRSK YHNHFHHNQQ HPQQPMVKLQ Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [251-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFYPVQPVLM AINNIARQIE YYFSEENLTV DNYLRSKLSK DGFAPLSLIS KFYRVVNMSF  60
   61 GGDTNLILAA LREIVANEAA TVNVAEGTLA AKEGDNVTGE AKEPSPLDKY FVRSKSWSNW 120
  121 LPETFETEIN IEKELVGDAL DQFMISLPPV PQQEEESSTE LASQEQETKE DSAPVAAGES 180
  181 ESSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1s7aA_
Description: NMR structure of the La motif of human La protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.16805061653531 bayes_pls_golite062009
nucleic acid binding 3.10560219735181 bayes_pls_golite062009
DNA binding 2.97348943886804 bayes_pls_golite062009
structural constituent of ribosome 2.95301685898669 bayes_pls_golite062009
structural molecule activity 2.70976099158766 bayes_pls_golite062009
binding 2.29601364076827 bayes_pls_golite062009
transcription factor activity 2.27922300995509 bayes_pls_golite062009
sequence-specific DNA binding 0.93130370844712 bayes_pls_golite062009
transcription activator activity 0.782193398686323 bayes_pls_golite062009
transcription repressor activity 0.67795138236883 bayes_pls_golite062009
RNA binding 0.345456982950223 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.10854873707001 bayes_pls_golite062009
protein binding 0.057263185425224 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle