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View Structure Prediction Details

Protein: FUN19
Organism: Saccharomyces cerevisiae
Length: 413 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUN19.

Description E-value Query
Range
Subject
Range
gi|207348022 - gi|207348022|gb|EDZ74003.1| YAL034Cp-like protein [Saccharomyces cerevisiae AWRI1631]
FUN19 - Non-essential protein of unknown function; expression induced in response to heat stress
502.0 [0..1] [413..51]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLYSPESEK SQLNMNYIGK DDSQSIFRRL NQNLKASNNN NDSNKNGLNM SDYSNNSPYG  60
   61 RSYDVRINQN SQNNGNGCFS GSIDSLVDEH IIPSPPLSPK LESKISHNGS PRMASSVLVG 120
  121 STPKGAVENV LFVKPVWPNG LSRKRYRYAT YGFLSQYKIF SNLAQPYSKN IINRYNNLAY 180
  181 NARHKYSKYN DDMTPPPLPS SSSRLPSPL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [210-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPNLNRQAR YNMRKQALYN NNLGKFESDT EWIPRKRKVY SPQRRTMTTS PHRAKKFSPS  60
   61 ASTPHTNIAS IEAIHDAPQY IPNVSWKKLP DYSPPLSTLP TDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.544 N/A N/A a.77.1 DEATH domain
View Download 0.501 N/A N/A a.109.1 Class II MHC-associated invariant chain ectoplasmic trimerization domain
View Download 0.429 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.402 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.401 N/A N/A a.61.1 Retroviral matrix proteins

Predicted Domain #3
Region A:
Residues: [313-413]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSLKIEWKG SPMDLSTDPL RNELHPAELV LAQTLRLPCD LYLDSKRRLF LEKVYRLKKG  60
   61 LPFRRTDAQK ACRIDVNKAS RLFQAFEKVG WLQDSNFTKY L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 2aqeA
Description: Structural and functional analysis of ada2 alpha swirm domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.61657063316558 bayes_pls_golite062009
DNA binding 3.20600447901865 bayes_pls_golite062009
nucleic acid binding 3.13775670276163 bayes_pls_golite062009
transcription factor activity 2.61318050866004 bayes_pls_golite062009
sequence-specific DNA binding 2.14408928200987 bayes_pls_golite062009
binding 2.12643314274039 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.77209608685482 bayes_pls_golite062009
transcription activator activity 1.75864690109096 bayes_pls_golite062009
protein binding 1.62529996900514 bayes_pls_golite062009
transcription repressor activity 0.605733396003465 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.380372494934551 bayes_pls_golite062009
chromatin binding 0.346262410069781 bayes_pls_golite062009
transcription factor binding 0.109547968922689 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle