YRC Public Data Repository - Protein Structure Prediction

Protein:	AIM45
Organism:	Saccharomyces cerevisiae
Length:	344 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIM45.

Description	E-value	Query Range	Subject Range
gi\|110683569, gi... - gi\|110803068\|ref\|YP_699559.1\| 3-hydroxybutyryl-CoA dehydrogenase [Clostridium perfringens SM101], gi... gi\|169347036, gi... - gi\|169347036\|ref\|ZP_02865978.1\| electron transfer flavoprotein, alpha subunit/FixB family protein [C... gi\|110675369, gi... - gi\|110800722\|ref\|YP_696972.1\| 3-hydroxybutyryl-CoA dehydrogenase [Clostridium perfringens ATCC 13124... gi\|168213209, gi... - gi\|170715257\|gb\|EDT27439.1\| electron transfer flavoprotein, alpha subunit/FixB family protein [Clost... gi\|168211631, gi... - gi\|170710398\|gb\|EDT22580.1\| electron transfer flavoprotein, alpha subunit/FixB family protein [Clost... gi\|18145963, gi\|... - gi\|18311280\|ref\|NP_563214.1\| 3-hydroxybutyryl-CoA dehydrogenase [Clostridium perfringens str. 13], g...	3.0E-96	[19..344]	[3..332]
gi\|28317158 - gi\|28317158\|gb\|AAD46853.2\|AF160913_1 LD07532p [Drosophila melanogaster]	4.0E-96	[1..340]	[11..340]
gi\|48734683, gi\|... - gi\|48734683\|gb\|AAH71394.1\| Electron-transfer-flavoprotein, alpha polypeptide [Danio rerio], gi\|38707...	7.0E-96	[25..342]	[22..333]
gi\|20162441 - gi\|20162441\|gb\|AAM14585.1\|AF494018_4 electron-transferring flavoprotein alpha-subunit [Clostridium b...	3.0E-95	[20..344]	[4..332]
gi\|28204452, gi\|... - gi\|28212009\|ref\|NP_782953.1\| electron transfer flavoprotein alpha-subunit [Clostridium tetani E88], ...	5.0E-95	[20..344]	[4..333]
ETFA_CLOTS - Electron transfer flavoprotein subunit alpha OS=Clostridium thermosaccharolyticum GN=etfA PE=3 SV=1 gi\|1667354\|emb\|C... - electron transfer flavoprotein alpha-subunit [Thermoanaerobacterium thermosaccharolyticum], electron...	2.0E-94	[21..344]	[3..330]
ETFA - electron-transfer-flavoprotein, alpha polypeptide gi\|61360604, gi\|... - gi\|61360611\|gb\|AAX41889.1\| electron-transfer-flavoprotein alpha polypeptide [synthetic construct], g...	8.0E-94	[11..342]	[3..332]
gi\|20804172 - gi\|20804172\|emb\|CAD31375.1\| PROBABLE ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT NITROGEN FIXATION FIXB [...	8.0E-94	[8..343]	[12..358]

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Predicted Domain #1

Region A:
Residues: [1-212]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKSLAAVLP RASKAKFLQK NYASTLAFIE SSKDGSVSRS SLSLLAAAQK LSNPITAVIT  60
   61 GSKAEKTAEA LKSSYSCSNL EKLVIFEDSK LDTCLPEQLT PLLVKLLKGG DYSHFVVSNS 120
  121 SVGKSVLPRV GALLDVQPVC EVTVIKDPKT FIRPIYAGNI ISTIECQAEK KLLIIRASAF 180
  181 PPIAEGSMDS VTIEKRTDIP PCDLNVTWVK TI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	827.533179
Match:	1efvA_
Description:	Large, alpha subunit of electron transfer flavoprotein ETFP, N-terminal domain; C-terminal domain of the electron transfer flavoprotein alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transmembrane transporter activity	4.33384561938284	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.17090195647007	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.43050424621229	bayes_pls_golite062009
cation transmembrane transporter activity	3.14018048674666	bayes_pls_golite062009
ion transmembrane transporter activity	2.86768332627553	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.45193593399776	bayes_pls_golite062009
substrate-specific transporter activity	2.3220778881858	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.31136100530959	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	1.78592865044375	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	1.78592865044375	bayes_pls_golite062009
histone deacetylase activity	1.78491508784517	bayes_pls_golite062009
protein deacetylase activity	1.78342765644164	bayes_pls_golite062009
electron carrier activity	1.52362724809555	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.45879345100257	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1.4419048058443	bayes_pls_golite062009
oxidoreductase activity	1.38926599384969	bayes_pls_golite062009
binding	1.19942441653074	bayes_pls_golite062009
deacetylase activity	1.06362010083501	bayes_pls_golite062009
ligase activity	1.02544349488516	bayes_pls_golite062009
GMP synthase (glutamine-hydrolyzing) activity	0.800567195533497	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
transcription factor binding	0.53102732418854	bayes_pls_golite062009
transcription regulator activity	0.511639683598669	bayes_pls_golite062009
protein binding	0.498410485514887	bayes_pls_golite062009
DNA binding	0.42016159460068	bayes_pls_golite062009
nucleic acid binding	0.401471604772125	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.38398632593091	bayes_pls_golite062009
transferase activity	0.105059877056256	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [213-344]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTKSERPELT SAQNVVTGGR ALKDKETFEK LLSPLADVLH AAIGATRASV DNGLCDNSLQ  60
   61 IGQTGKVVAP NLYIAIGVSG AVQHLAGMKD SKVIVAINND PDAPIFNVAD YGLQGDLYKI 120
  121 VPELTEKLGK YK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	827.533179
Match:	1efvA_
Description:	Large, alpha subunit of electron transfer flavoprotein ETFP, N-terminal domain; C-terminal domain of the electron transfer flavoprotein alpha subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: