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View Structure Prediction Details

Protein: YPL150W
Organism: Saccharomyces cerevisiae
Length: 901 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPL150W.

Description E-value Query
Range
Subject
Range
YPL150W - Putative protein kinase of unknown cellular role
YP150_YEAST - Putative serine/threonine-protein kinase YPL150W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
0.0 [1..901] [1..901]
gi|3089349 - gi|3089349|gb|AAC15093.1| Cdc25C associated protein kinase C-TAK1 [Homo sapiens]
0.0 [6..722] [21..687]
gi|7595802, gi|1... - gi|7595802|gb|AAF64456.1|AF240783_1 ELKL motif kinase 2 short form [Mus musculus], gi|12313875|ref|N...
0.0 [6..722] [21..687]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..722] [21..671]
MARK3_RAT - MAP/microtubule affinity-regulating kinase 3 OS=Rattus norvegicus GN=Mark3 PE=1 SV=1
0.0 [6..722] [21..755]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNPVGSSKL EQNNIKSIIG SSYNRLYSQF TSDELTEVGN YKILKQIGEG SFGKVYLALH  60
   61 RPTHRKVCLK TSDKNDPNIV 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [98-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEVIVTESKV WMAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 447.228787
Match: 1gznA_
Description: Pkb kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [81-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REVFYHRQFD FPYITKL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [112-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYCPGKELYD HLLSLRRISL LECGELFAQI SGAVYYAHSM HCVHRDLKLE NILLDKNGNA  60
   61 KLTDFGFTRE CMTKTTLETV CGTTVYMAPE LIERRTYDGF KIDIWSLGVI LYTLITGYLP 120
  121 FDDDDEAKTK WKIVNEEPKY DAKVIPDDAR DLISRLLAKN PGERPSLSQV LRHPFLQPYG 180
  181 SVVLDQTQKI LCRQRSGGTQ FKSKLERRLL KRLKQSGVDT QAIKQSILKK KCDSLSGLWL 240
  241 LLLAQGKKQE NCKYPKRSRS VLSVKKVIES ATHNDTNGIS EDVLKPSLEL SRAASLSKML 300
  301 NKGSDFVTSM T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 447.228787
Match: 1gznA_
Description: Pkb kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [423-901]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVSRKKSKDS AKVLNPTLSK ISSQRAYSHS IAGSPRKSNN FLQKVSSFFK SKKSSNSNSN  60
   61 NSIHTNVSES LIASNRGAPS SGSFLKKNSG SIQKSRTDTV ANPSRTESIG SLNENVAGAI 120
  121 VPRSANNTTL ENKKTSGNEI GLKVAPELLL NEHIRIEEPR LKRFKSSISS EISQTSTGNY 180
  181 DSESAENSRS ISFDGKVSPP PIRNRPLSEI SQISNDTYIS EYSTDGNNSS FKISDTIKPS 240
  241 YIRKGSETTS QYSASSEKMT NGYGRKFVRR DLSIVSTASS TSERSSRTDS FYDITTATPV 300
  301 VTTDNRRNKN NNLKESVLPR FGTQRPWTGK RTYTTSRHGK NARRSSKRGL FKITSSNTDS 360
  361 IIQEVSSSEE EDHNVIYSKG KGLPTPVLQT KGLIENGLNE RDEEGDDEYA IHTDGEFSIK 420
  421 PQFSDDVIDK QNHLPSVKAV ATKRSLSEGS NWSSSYLDSD NNRRRVSSLL VEDGGNPTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [671-727]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSQYSASSEK MTNGYGRKFV RRDLSIVSTA SSTSERSSRT DSFYDITTAT PVVTTDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1ul7A
Description: Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 4.05475891009228 bayes_pls_golite062009
protein serine/threonine kinase activity 3.7974128326421 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 3.59230737331367 bayes_pls_golite062009
kinase activity 3.41737435609334 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 3.2342722637405 bayes_pls_golite062009
binding 2.41732321506551 bayes_pls_golite062009
transferase activity 2.04713540681686 bayes_pls_golite062009
ATP binding 1.44435058039859 bayes_pls_golite062009
adenyl ribonucleotide binding 1.41005152726625 bayes_pls_golite062009
adenyl nucleotide binding 1.38971642420542 bayes_pls_golite062009
ribonucleotide binding 1.16863558166547 bayes_pls_golite062009
purine ribonucleotide binding 1.16859376715941 bayes_pls_golite062009
purine nucleotide binding 1.15633908642115 bayes_pls_golite062009
nucleotide binding 1.14964488472581 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
protein binding 0.704339182896017 bayes_pls_golite062009
AMP-activated protein kinase activity 0.496765880715405 bayes_pls_golite062009
magnesium ion binding 0.439688030503848 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [728-901]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRNKNNNLKE SVLPRFGTQR PWTGKRTYTT SRHGKNARRS SKRGLFKITS SNTDSIIQEV  60
   61 SSSEEEDHNV IYSKGKGLPT PVLQTKGLIE NGLNERDEEG DDEYAIHTDG EFSIKPQFSD 120
  121 DVIDKQNHLP SVKAVATKRS LSEGSNWSSS YLDSDNNRRR VSSLLVEDGG NPTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle