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View Structure Prediction Details

Protein: YPL060C-A
Organism: Saccharomyces cerevisiae
Length: 1104 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPL060C-A.

Description E-value Query
Range
Subject
Range
YHL009W-B - Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is proces...
YH41B_YEAST - Transposon Ty4-H Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY4...
654.0 [0..1] [1101..1]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATPVRDETR NVIDDNISAR IQSKVKTNDT VRQTPSSLRK VSIKDEQVKQ YQRNLNRFKT  60
   61 ILNGLKAEEE KLSETDDIQM LAEKLLKLGE TIDKVENRIV DLVEKIQLLE TNENNNILHE 120
  121 HI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [123-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATGTYYLFD TLTSTNKRFY PKDCVFDYRT NNVENIPILL NNFKKFIKKY QFDDVFENDI  60
   61 IEIDPRENEI LCKIIKEGLG ESLDIMNTNT TDIFRIIDGL KNKYRSLHGR DVRIRAWEKV 120
  121 LVDTTCRNSA LLMNKLQKLV LMEKWIFSKC CQDCPNLKDY LQEAIMGTLH ESLRNSVKQR 180
  181 LYNIPHNVGI NHEEFLINTV IETVIDLSPI ADDQIENSCM YCKSVFHCSI NCKKKPNREL 240
  241 RPDSTNFSKT YYLQGAQRQQ QLKSSAKEQK SWNKTQKKSN KVYNSKKLVI IDTGSGVNIT 300
  301 NDKTLLHNYE DSNRSTRFFG IGKNSSVSVK GYGYIKIKNG HNNTDNKCLL TYYVPEEEST 360
  361 IISCYDLAKK TKMVLSRKYT RLGNKIIKIK TKIVNGVIHV KMNELIERPS DDSKINAIKP 420
  421 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1bqnA
Description: HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleotidyltransferase activity 2.08067737569595 bayes_pls_golite062009
DNA polymerase activity 1.30231569478597 bayes_pls_golite062009
DNA-directed DNA polymerase activity 1.29719382213292 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.19125536460488 bayes_pls_golite062009
ribonuclease activity 0.969438660919194 bayes_pls_golite062009
binding 0.681153419173075 bayes_pls_golite062009
transferase activity 0.564818692007078 bayes_pls_golite062009
catalytic activity 0.506386500680103 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.139403453656723 bayes_pls_golite062009
RNA polymerase activity 0.139403453656723 bayes_pls_golite062009
nucleic acid binding 0.0649376648268392 bayes_pls_golite062009
DNA binding 0.0337904155200424 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [544-868]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPGFKLNKR SITLEDAHKR MGHTGIQQIE NSIKHNHYEE SLDLIKEPNE FWCQTCKISK  60
   61 ATKRNHYTGS MNNHSTDHEP GSSWCMDIFG PVSSSNADTK RYMLIMVDNN TRYCMTSTHF 120
  121 NKNAETILAQ IRKNIQYVET QFDRKVREIN SDRGTEFTND QIEEYFISKG IHHILTSTQD 180
  181 HAANGRAERY IRTIVTDATT LLRQSNLRVK FWEYAVTSAT NIRNCLEHKS TGKLPLKAIS 240
  241 RQPVTVRLMS FLPFGEKGII WNHNHKKLKP SGLPSIILCK DPNSYGYKFF IPSKNKIVTS 300
  301 DNYTIPNYTM DGRVRNTQNI YKSHQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.30103
Match: 1k6yA
Description: N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.94987701094917 bayes_pls_golite062009
ribonuclease activity 0.969438660919194 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.787213833707638 bayes_pls_golite062009
exonuclease activity 0.738049151007118 bayes_pls_golite062009
catalytic activity 0.709734459150736 bayes_pls_golite062009
3'-5' exonuclease activity 0.332143782945747 bayes_pls_golite062009
hydrolase activity 0.301910249637397 bayes_pls_golite062009
binding 0.205040227344888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [869-1007]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSHNDNEED QIETVTNLCE ALENYEDDNK PITRLEDLFT EEELSQIDSN AKYPSPSNNL  60
   61 EGDLDYVFSD VEESGDYDVE SELSTTNTSI STDKNKILSN KDFNSELAST EISISEIDKK 120
  121 GLINTSHIDE DKYDEKVHR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1008-1104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPSIIQEKLV GSKNTIKIND ENRISDRIRS KNIGSILNTG LSRCVDITDE SITNKDESMH  60
   61 NAKPELIQEQ FNKTNHETSF PKEGSIGTKC KIPKYRQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle