YRC Public Data Repository - Protein Structure Prediction

Protein:	HAT1
Organism:	Saccharomyces cerevisiae
Length:	374 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAT1.

Description	E-value	Query Range	Subject Range
HAT1_YEAST - Histone acetyltransferase type B catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 /... HAT1 - Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl... gi\|207340437 - gi\|207340437\|gb\|EDZ68786.1\| YPL001Wp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..374]	[1..374]
gi\|55613955 - gi\|55613955\|ref\|XP_515904.1\| PREDICTED: similar to histone acetyltransferase 1 isoform 4 [Pan troglo... HAT1 - histone acetyltransferase 1	0.0	[2..369]	[16..416]
gi\|45383710, gi\|... - gi\|9963998\|gb\|AAG09795.1\|AF257739_1 histone acetyltransferase-1 [Gallus gallus], gi\|45383710\|ref\|NP_...	0.0	[1..369]	[4..405]
HAT1_MOUSE - Histone acetyltransferase type B catalytic subunit OS=Mus musculus GN=Hat1 PE=1 SV=1	0.0	[2..369]	[13..413]
FBpp0078318, CG2... - This gene is referred to in FlyBase by the symbol Dmel\CG2051 (CG2051, FBgn0037376). It is a protein...	0.0	[24..372]	[29..405]
tag-235 - status:Partially_confirmed UniProt:Q21484 protein_id:CAA88954.1	0.0	[26..372]	[165..530]
HAT12_DICDI - Histone acetyltransferase type B catalytic subunit DDB_G0275159 OS=Dictyostelium discoideum GN=DDB_G... gi\|60471906, gi\|... - gi\|66820394\|ref\|XP_643818.1\| histone acetyltransferase [Dictyostelium discoideum AX4], gi\|60471906\|g...	5.0E-99	[25..354]	[49..388]
HAT1_NEUCR - Histone acetyltransferase type B catalytic subunit OS=Neurospora crassa (strain ATCC 24698 / 74-OR23... HAT1_NEUCR - Histone acetyltransferase type B catalytic subunit OS=Neurospora crassa GN=hat-1 PE=3 SV=1	2.0E-98	[8..366]	[4..450]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANDFKPET WTSSANEALR VSIVGENAVQ FSPLFTYPIY GDSEKIYGYK DLIIHLAFDS  60
   61 VTFKPYVNVK YSAKLGDDNI VDVEKKLLSF LPKDDVIVRD EAKWVDCFAE ER

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1865.0
Match:	1bob__
Description:	Histone acetyltransferase HAT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	10.330867741687	bayes_pls_golite062009
histone acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
lysine N-acetyltransferase activity	10.2385402730839	bayes_pls_golite062009
N-acyltransferase activity	10.2097972775096	bayes_pls_golite062009
acetyltransferase activity	9.5414870492393	bayes_pls_golite062009
acyltransferase activity	8.84144467104026	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	8.80032457938662	bayes_pls_golite062009
transferase activity, transferring acyl groups	8.58458341779614	bayes_pls_golite062009
	7.30820970670781	bayes_pls_golite062009
	3.86052919290021	bayes_pls_golite062009
transferase activity	2.87429355361226	bayes_pls_golite062009
transcription regulator activity	2.24760844790231	bayes_pls_golite062009
nucleic acid binding	2.13750665291344	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transcription repressor activity	1.31507488567214	bayes_pls_golite062009
binding	1.22537494136129	bayes_pls_golite062009
transcription coactivator activity	1.2180007740195	bayes_pls_golite062009
transcription factor binding	1.13174003342838	bayes_pls_golite062009
myristoyltransferase activity	0.952148883380044	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.952148883380044	bayes_pls_golite062009
transcription activator activity	0.891911076312861	bayes_pls_golite062009
H3 histone acetyltransferase activity	0.710926740598251	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.483579890542134	bayes_pls_golite062009
transcription cofactor activity	0.31196049232138	bayes_pls_golite062009
protein binding	0.075825416385311	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [113-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTHNLSDVFE KVSEYSLNGE EFVVYKSSLV DDFARRMHRR VQIFSLLFIE AANYIDETDP  60
   61 SWQIYWLLNK KTKELIGFVT TYKYWHYLGA KSFDEDIDKK FRAKISQFLI FPPYQNKGHG 120
  121 SCLYEAIIQS WLEDKSITEI TVEDPNEAFD DLRDRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1865.0
Match:	1bob__
Description:	Histone acetyltransferase HAT1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [269-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIQRLRKLGY DAVFQKHSDL SDEFLESSRK SLKLEERQFN RLVEMLLLLN NSPSFELKVK  60
   61 NRLYIKNYDA LDQTDPEKAR EALQNSFILV KDDYRRIIES INKSQG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1865.0
Match:	1bob__
Description:	Histone acetyltransferase HAT1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

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Top Sequence Alignment Hits

Predicted functions: