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View Structure Prediction Details

Protein: GPB1
Organism: Saccharomyces cerevisiae
Length: 897 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPB1.

Description E-value Query
Range
Subject
Range
GPB1 - Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby incre...
GPB1_YEAST - Guanine nucleotide-binding protein subunit beta 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
0.0 [1..897] [1..897]
gi|71072673, gi|... - gi|71072673|ref|XP_768891.1| hypothetical protein GLP_47_40415_39147 [Giardia lamblia ATCC 50803], g...
ctg02_16|6072|Hy... - protein
GL50803_6072 - | organism=Giardia_Assemblage_A_isolate_WB | product=hypothetical protein | location=GLCHR02:705408-...
0.001 [659..756] [282..384]

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Predicted Domain #1
Region A:
Residues: [1-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQASTFGSH SLEAHPLHIQ PAVHIKLSKE ERSHYREQYD SLKYISNYVS VFDQALSDNI  60
   61 DSRIRKENEA LLKKYYESRK PFTFTSFRQG SVISSSDSST GFTERTKTYC FLNDFVSNCV 120
  121 NEVDPYTLKM TVRNRNTALN MENLDDERKS KDDIYDFEDN TDDECNAKCH GAFHYSSERL 180
  181 EILRSRSTIS YFKYYKKLLT VDLRDSDVLK RHNLWMPMIT RRFRFLLVSS SKPEDVRLTT 240
  241 PIPTFSESDL DIFKNKTCPL FINGTDCVPR SYDTFSGSSV IASIFSEYKL PSLSYHCSVE 300
  301 LNDQLFIVGG LMACHRYDEE APDLKDFYVD GIKNLPPPLI PELINNPSMI PNPHLYCFSL 360
  361 TSSRLTRPDI SGYIPPPLVC TQGCKLTERH IFLYGGFEIK SETQVDDKGR YFIRKRAFLN 420
  421 NTGYILDTVT FNFSKIELVA PPYQFAIYNN FSPRFGHMQA SISNSNNNVS NENTTTSAKG 480
  481 RRSISPYRQG NGDHKIDDLV GSPGSTDYLE DDAIPPVTNP RSTDSLSSKH CSTATHICSS 540
  541 VNTILIFGGY SQTGDDKYEA MNDMWKINIP VVSRGKRNYY KFADTVTATK IPIIDDPELW 600
  601 PSRRAFSACC VPDYFTKDVE PIETRLLRNL KNDFSIDLEI RPGNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [646-794]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQPLFPNIP HSRKEKKSGR DSMHISNSNN STSEDTSSKS TRNTTSSPPT SPKHTPPLNP  60
   61 SKKCASIGRT IAFHGGSDGY DVCSDMWWFD FDSETWTKID LYAKTQEESD GLVPINLCMV 120
  121 GHSMTTVGHK VVLIGGLRQG DVDRIYRDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.333 0.598 signal transduction b.55.1 PH domain-like
View Download 0.210 0.135 signal transduction c.47.1 Thioredoxin-like
View Download 0.450 0.044 cytoplasm d.109.1 Actin depolymerizing proteins

Predicted Domain #3
Region A:
Residues: [795-897]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLPEEVISGV PLGSGVINVV DLNTQCLQGC KLIRNDGDTK ESVIMDPHVG TPHQVLAVAG  60
   61 TIELVKGTMT LIGGVVAGRE DISSLYLRGA VLQFILPSMN LAN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.510 d.93.1 SH2 domain
View Download 0.370 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.365 b.26.1 SMAD/FHA domain
View Download 0.369 a.74.1 Cyclin-like
View Download 0.391 a.28.1 ACP-like
View Download 0.314 d.130.1 S-adenosylmethionine synthetase
View Download 0.300 c.51.2 TolB, N-terminal domain
View Download 0.297 a.7.7 BAG domain
View Download 0.238 a.133.1 Phospholipase A2, PLA2
View Download 0.235 f.14.1 Voltage-gated potassium channels
View Download 0.232 c.48.1 TK C-terminal domain-like
View Download 0.224 d.110.1 Profilin (actin-binding protein)
View Download 0.213 d.24.1 Pili subunits


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle