YRC Public Data Repository - Protein Structure Prediction

Protein:	UAF30
Organism:	Saccharomyces cerevisiae
Length:	228 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UAF30.

Description	E-value	Query Range	Subject Range
UAF30 - Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription sti... gi\|190407596 - gi\|190407596\|gb\|EDV10863.1\| hypothetical protein SCRG_01676 [Saccharomyces cerevisiae RM11-1a] UAF30_YEAST - Upstream activation factor subunit UAF30 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	2.0E-57	[1..228]	[1..228]
SMRD1_MOUSE, SCD... - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Mus...	4.0E-50	[39..224]	[205..394]
gi\|114644841, gi... - gi\|114644841\|ref\|XP_001155587.1\| PREDICTED: SWI/SNF-related matrix-associated actin-dependent regula... gi\|4566530 - gi\|4566530\|gb\|AAD23390.1\|AF109733_1 SWI/SNF-related, matrix-associated, actin-dependent regulator of... gi\|109096590 - gi\|109096590\|ref\|XP_001110916.1\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-depen... tr\|G3HX65\|G3HX65... - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Cri...	5.0E-49	[39..224]	[146..335]
gi\|195566518, gi... - gi\|195566518\|ref\|XP_002106827.1\| GD15903 [Drosophila simulans], gi\|194204219\|gb\|EDX17795.1\| GD15903 ... Bap60-PA - The gene Brahma associated protein 60kD is referred to in FlyBase by the symbol Dmel\Bap60 (CG4303, ...	1.0E-47	[39..224]	[211..397]
gi\|25405318, gi\|... - gi\|5430749\|gb\|AAD43149.1\|AC007504_4 Hypothetical Protein [Arabidopsis thaliana], pir\|\|A96532 hypothe...	1.0E-46	[1..223]	[1..206]
SMRD2_RAT - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Rat...	5.0E-45	[39..224]	[231..413]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-45	[39..224]	[231..413]

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Predicted Domain #1

Region A:
Residues: [1-99]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELNDYSTM IDILLSDMDL ETVTTKKVRM ALKEVYAIDV ESQGKAINKL IRKHLDLVKE  60
   61 RPRFERSLED LLKENATLAI ELTKEITVSK RSSGEEKND

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.855	0.093	RNA polymerase I transcription factor activity	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain

Predicted functions:

Term	Confidence	Notes
binding	2.63842828741542	bayes_pls_golite062009
transcription regulator activity	2.62775554429027	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.953438255689584	bayes_pls_golite062009
histone binding	0.948950535074526	bayes_pls_golite062009
protein binding	0.529408559970229	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.439630834571696	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [100-228]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SETKGTHVEK KKGTVSKSPI STRKVTLSKS LASLLGEHEL TRTEVVRRLW AYIKAHNLQN  60
   61 PNNKKEILCD EKLELILGKS TNMFEMHKIL ASHMTEPKKI SDCPPLIQEV RRKEKPIVSD 120
  121 SEQSDTKGI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	49.769551
Match:	PF02201
Description:	SWIB/MDM2 domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.01592136607858	bayes_pls_golite062009
binding	3.20303599400601	bayes_pls_golite062009
basal transcription repressor activity	2.69162769894095	bayes_pls_golite062009
transcription coactivator activity	2.58234407051051	bayes_pls_golite062009
transcription repressor activity	1.98538788872171	bayes_pls_golite062009
transcription activator activity	1.83085389017135	bayes_pls_golite062009
transcription factor binding	1.73032563380905	bayes_pls_golite062009
transcription cofactor activity	1.60414428986898	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.51390743508971	bayes_pls_golite062009
protein binding	1.38134467541454	bayes_pls_golite062009
ligase activity	0.802664465339603	bayes_pls_golite062009
structural molecule activity	0.66106995897056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.15313128037113	bayes_pls_golite062009
catalytic activity	0.121624777548864	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: