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View Structure Prediction Details

Protein: HRK1
Organism: Saccharomyces cerevisiae
Length: 759 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRK1.

Description E-value Query
Range
Subject
Range
HRK1 - Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to gluc...
HRK1_YEAST - Serine/threonine-protein kinase HRK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRK...
0.0 [1..759] [1..759]
gi|9280653, gi|2... - gi|9280653|gb|AAF86522.1|AC002560_15 F21B7.34 [Arabidopsis thaliana], gi|240254006|ref|NP_171870.4| ...
0.0 [10..700] [4..729]
gi|7672782 - gi|7672782|gb|AAF66639.1|AF143743_1 SNF1 [Lycopersicon esculentum]
0.0 [213..565] [17..366]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [215..569] [8..359]
gi|4567091 - gi|4567091|gb|AAD23582.1|AF128443_1 SNF-1-like serine/threonine protein kinase [Glycine max]
0.0 [213..564] [18..366]
gi|125543425 - gi|125543425|gb|EAY89564.1| hypothetical protein OsI_11096 [Oryza sativa Indica Group]
gi|28201244, gi|... - gi|28201244|dbj|BAC56590.1| SnRK1b protein kinase [Oryza sativa Japonica Group], gi|169244479|gb|ACA...
gi|4107007, gi|4... - gi|4107007|dbj|BAA36297.1| OSK3 [Oryza sativa], gi|4107003|dbj|BAA36295.1| OSK5 [Oryza sativa]
0.0 [213..588] [15..382]
gi|575292 - gi|575292|emb|CAA57898.1| SNF1-related protein kinase [Hordeum vulgare subsp. vulgare]
0.0 [218..584] [1..364]

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Predicted Domain #1
Region A:
Residues: [1-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNLLSRNPF HGHHNDHHHD RENSSNNPPQ LIRSSKSFLN FIGRKQSNDS LRSEKSTDSM  60
   61 KSTTTTTNYT TTNLNNNTHS HSNATSISTN NYNNNYETNH HHNISHGLHD YTSPASPKQT 120
  121 HSMAELKRFF RPSVNKKLSM SQLRSKKHST HSPPPSKSTS TVNLNNHYRA QHPHGFTDHY 180
  181 A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [182-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTQSAIPPST DSILSLSNNI NIYHDDCILA QKYGKLGKLL GSGAGGSVKV LVRPTDGATF  60
   61 AVKEFRPRKP NESVKEYAKK CTAEFCIGST LHHPNVIETV DVFSDSKQNK YYEVMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 295.54902
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 2.08446867830553 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.03708864261503 bayes_pls_golite062009
binding 1.91026430843897 bayes_pls_golite062009
kinase activity 1.80709202193001 bayes_pls_golite062009
protein serine/threonine kinase activity 1.49093744407686 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35441545960336 bayes_pls_golite062009
protein binding 1.12583111976692 bayes_pls_golite062009
transferase activity 0.876865688160088 bayes_pls_golite062009
molecular adaptor activity 0.461801827875362 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.366024782440962 bayes_pls_golite062009
protein binding, bridging 0.25357576643216 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [299-380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPIDFFAVVM TGKMSRGEIN CCLKQLTEGV KYLHSMGLAH RDLKLDNCVM TSQGILKLID  60
   61 FGSAVVFRYP FEDGVTMAHG IV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [496-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASIQGKSDN KPDIVEEETE ENKEDDSNND KESTPDNDKE ST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 295.54902
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [381-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDPYLAPEV ITSTKSYDPQ CVDIWSIGII YCCMVLKRFP WKAPRDSDDN FR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 295.54902
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [433-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYCMPDDIEH DYVESARHHE ELLKERKEKR QRFLNHSDCS AINQQQPAHE SNLKTVQNQV  60
   61 PNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 295.54902
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [538-759]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDIKISKNEN KSTVVSANPK KVDADADADC DANGDSNGRV DCKANSDCND KTDCNANNDC  60
   61 SNESDCNAKV DTNVNTAANA NPDMVPQNNP QQQQQQQQQQ QQQQQQQQQQ HHHHQHQNQD 120
  121 KAHSIASDNK SSQQHRGPHH KKIIHGPYRL LRLLPHASRP IMSRILQVDP KKRATLDDIF 180
  181 NDEWFAAIAA CTMDSKNKVI RAPGHHHTLV REENAHLETY KV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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