YRC Public Data Repository - Protein Structure Prediction

Protein:	GET4
Organism:	Saccharomyces cerevisiae
Length:	312 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GET4.

Description	E-value	Query Range	Subject Range
gi\|190407483 - gi\|190407483\|gb\|EDV10750.1\| hypothetical protein SCRG_01557 [Saccharomyces cerevisiae RM11-1a] gi\|151945783 - gi\|151945783\|gb\|EDN64024.1\| conserved protein [Saccharomyces cerevisiae YJM789] GET4_YEAST - Golgi to ER traffic protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GET4 PE=1 ... GET4 - Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; i...	0.0	[1..312]	[1..312]
SPCC1672.12c - DUF410 family protein GET4_SCHPO - Golgi to ER traffic protein 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=get4 PE=3 SV...	2.0E-93	[17..310]	[5..292]
gi\|18376278, gi\|... - gi\|32412406\|ref\|XP_326683.1\| hypothetical protein [Neurospora crassa], gi\|28923103\|gb\|EAA32320.1\| co... gi\|85103607 - gi\|85103607\|ref\|XP_961556.1\| hypothetical protein NCU01190 [Neurospora crassa OR74A]	3.0E-83	[11..308]	[7..311]
cee-1 - status:Confirmed UniProt:Q19824 protein_id:AAA91216.1	4.0E-65	[14..291]	[3..283]

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Predicted Domain #1

Region A:
Residues: [1-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPAESNAVQ AKLAKTLQRF ENKIKAGDYY EAHQTLRTIA NRYVRSKSYE HAIELISQGA  60
   61 LSFLKAKQGG SGTDLIFYLL EVYDLAEVKV DDISVARLVR LIAELDPSEP NLKDVITGMN 120
  121 NWSIKFSEYK F

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.43
Match:	1qqeA
Description:	Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.64850159998065	bayes_pls_golite062009
transcription regulator activity	1.96534484578496	bayes_pls_golite062009
nucleic acid binding	1.64804251600372	bayes_pls_golite062009
DNA binding	1.63530462331869	bayes_pls_golite062009
protein binding	1.51322932625387	bayes_pls_golite062009
transcription factor activity	0.941893540415683	bayes_pls_golite062009
transcription factor binding	0.370606597126089	bayes_pls_golite062009
transcription cofactor activity	0.0874081614883346	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [132-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDPYLHNTIG SKLLEGDFVY EAERYFMLGT HDSMIKYVDL LWDWLCQVDD IEDSTVAEFF  60
   61 SRLVFNYLFI SNISFAHESK DIFLERFIEK FHPKYEKIDK NGYEIVFFED YSDLNFLQLL 120
  121 LITCQTKDKS YFLNLKNHYL DFSQAYKSEL EFLGQEYFNI VAPKQTNFLQ DMMSGFLGGS 180
  181 K

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.43
Match:	1qqeA
Description:	Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: