YRC Public Data Repository - Protein Structure Prediction

Protein:	CMR2
Organism:	Saccharomyces cerevisiae
Length:	1648 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CMR2.

Description	E-value	Query Range	Subject Range
CMR2 - Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-induc... YO093_YEAST - Uncharacterized protein YOR093C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOR093C ...	0.0	[1..1648]	[1..1648]
gi\|6563397 - gi\|6563397\|gb\|AAF15891.2\|AF204805_1 NosA [Nostoc sp. GSV224]	0.0	[4..982]	[1396..2246]
gi\|9715733 - gi\|9715733\|emb\|CAC01603.1\| peptide synthetase [Anabaena circinalis 90]	0.0	[4..896]	[1480..2233]
gi\|17131741, gi\|... - gi\|17230140\|ref\|NP_486688.1\| peptide synthetase [Nostoc sp. PCC 7120], gi\|17131741\|dbj\|BAB74347.1\| p... gi\|25294032 - pir\|\|AI2136 peptide synthetase [imported] - Nostoc sp. (strain PCC 7120)	0.0	[4..982]	[294..1128]
TYCC_BREPA - Tyrocidine synthase 3 OS=Brevibacillus parabrevis GN=tycC PE=1 SV=1 gi\|2623773, gi\|7... - gi\|7522159\|pir\|\|T31076 tyrocidine synthetase 3 - Brevibacillus brevis, gi\|2623773\|gb\|AAC45930.1\| tyr...	0.0	[4..1007]	[1333..2177]
DHBF_BACSU - Dimodular nonribosomal peptide synthetase OS=Bacillus subtilis GN=dhbF PE=1 SV=3 gi\|50812288, gi\|... - gi\|50812288\|ref\|NP_391076.2\| involved in siderophore 2,3-dihydroxybenzoate (DHB) synthesis [Bacillus...	0.0	[4..999]	[1342..2223]

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Predicted Domain #1

Region A:
Residues: [1-61]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFSIPPTLP LDLQSRLNEL IQDYKDENLT RKGYETKRKQ LLDKFEISQM RPYTPLRSPN  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [62-139]

      1          11         21         31         41         51         
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    1 RKSKHLHRRN TSLASSITSL PNSIDRRHSI YRVTTINSTS ANNTPRRRSK RYTASLQSSL  60
   61 PGSSDENGSV KDAVYNPM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.06902368506559	bayes_pls_golite062009
ligase activity	0.763554068965808	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	0.619465698462354	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [140-154]

      1          11         21         31         41         51         
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    1 IPLLPRHTGA ENTSS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [425-701]

      1          11         21         31         41         51         
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    1 DSSILQRPGG YENIIDKFRA DILLNDQLQL KQVVINYLEN PESAFSKKHK IDFSCIKSCL  60
   61 TSCTTIDTDV SEMVVHKWLK NLGCIDAPFC YSPMLTLLDF GGIFISIRDQ LGNLENFPIH 120
  121 NSKLRLQNEL FINREKLKLN EVECSITAMI NSSSSFKDYL KLETFGFPIP DITLCVVNPD 180
  181 TNTLVQDLTV GEIWISSNHI TDEFYQMDKV NEFVFKAKLN YSEMFSWAKY EMPTNEKSQA 240
  241 VTEQLDTILN ICPANTYFMR TKLMGFVHNG KIYVLSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	131.0
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transporter activity	0.205687421762746	bayes_pls_golite062009
transporter activity	0.164841961310903	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [155-196]

      1          11         21         31         41         51         
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    1 GDSAMTDSLP LILRGRFEHY DGQTAMISIN SKGKETFITW DK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [337-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPLGRLSGVV MKHNILINQF ETMTKILNSR SMPHWKQKSQ SIRKPFHKKI MATNSRFVIL  60
   61 NSLDPTRSTG LIMGVLFNLF TGNLMISI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [702-832]

      1          11         21         31         41         51         
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    1 IEDMFLQNRL IRLPNWAHTS NLLYAKKGNQ SAQPKGNTGA ESTKAIDISS LSGETSSGYK  60
   61 RVVESHYLQQ ITETVVRTVN TVFEVAAFEL QHHKEEHFLV MVVESSLAKT EEESKNGETT 120
  121 DTTLMKFAET Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	131.0
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [197-336]

      1          11         21         31         41         51         
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    1 LYLKAERVAH ELNKSHLYKM DKILLWYNKN DVIEFTIALL GCFISGMAAV PVSFETYSLR  60
   61 EILEIIKVTN SKFVLISNAC HRQLDNLYSS SNHSKVKLVK NDVFQQIKFV KTDDLGTYTK 120
  121 AKKTSPTFDI PNISYIEFTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	131.0
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [833-910]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNKLETKMND LTDQIFRILW IFHKIQPMCI LVVPRDTLPR RYCSLELANS TVEKKFLNND  60
   61 LSAQFVKFQF DNVILDFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.045757
Match:	1dnyA_
Description:	Peptidyl carrier protein (PCP), thioester domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [911-973]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSAYYNESI LSEHLSKLRK MALQEEYAMI EPAYRNGGPV KPKLALQCSG VDYRDESVDT  60
   61 RSH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.837	a.65.1	Annexin

Predicted Domain #8

Region A:
Residues: [974-1009]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKLTDFKSIL EILEWRISNY GNETAFSDGT NTNLVN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1023-1175]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWASFGKIVA GFLKKIVGSK IPLKHGDPII IMCENSVEYV AMIMACLYCN LLVIPLPSVK  60
   61 ESVIEEDLKG LVNIIQSYKV KRVFVDAKLH SLLNDNNVVN KCFKKYKSLI PKITVFSKVK 120
  121 TKNALTVSMF KNVLKQKFGA KPGTRIGMTP CVV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.09691
Match:	1ba3__
Description:	Luciferase
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1010-1022]

      1          11         21         31         41         51         
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    1 SSASNDNNVH KKV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1176-1510]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WVNTEYDVTS NIHVTMTHSS LLNASKIVKE TLQLRNNSPL FSICSHTSGL GFMFSCLLGI  60
   61 YTGASTCLFS LTDVLTDPKE FLIGLQNLNV KDLYLKLETL YALLDRASSL IEGFKNKKEN 120
  121 INSAKNNTSG SLREDVFKGV RNIMIPFPNR PRIYTIENIL KRYSTISLSC TQISYVYQHH 180
  181 FNPLISLRSY LDIPPVDLYL DPFSLREGII REVNPNDVSA GNYIKIQDSG VVPVCTDVSV 240
  241 VNPETLLPCV DGEFGEIWCC SEANAFDYFV CNSSKNKLYK DPFITEQFKS KMKSEVNNTL 300
  301 SYLRTGDLGF IKNVSCTNSQ GEVVNLNLLF VLGSI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.09691
Match:	1ba3__
Description:	Luciferase
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [1511-1648]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HESIEILGLT HFVSDLERTV KDVHSDIGSC LIAKAGGLLV CLIRCKERHN PILGNLTTLI  60
   61 VSELLNKHGV ILDLCTFVRT KGISPKNSSM IMEVWAKNRA SIMQAWFDQK IQIEAQFGIN 120
  121 YGENISIYLL SDYEKDNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.09691
Match:	1ba3__
Description:	Luciferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: