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View Structure Prediction Details

Protein: HMS1
Organism: Saccharomyces cerevisiae
Length: 434 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMS1.

Description E-value Query
Range
Subject
Range
HMS1_YEAST - Probable transcription factor HMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMS1 ...
HMS1 - Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpre...
6.0E-84 [1..434] [1..434]
MITF - microphthalmia-associated transcription factor
8.0E-56 [6..409] [30..439]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-55 [6..409] [30..433]
MITF_MOUSE - Microphthalmia-associated transcription factor OS=Mus musculus GN=Mitf PE=1 SV=3
2.0E-53 [6..408] [30..438]
gi|19072732 - gi|19072732|gb|AAL84611.1|AF475091_1 microphtalmia-associated transcription factor MITF-B [Xiphophor...
9.0E-53 [24..420] [1..395]
gi|64903 - gi|64903|emb|CAA32911.1| unnamed protein product [Xenopus laevis]
1.0E-51 [24..371] [103..417]
MYCN_CHICK - N-myc proto-oncogene protein OS=Gallus gallus GN=MYCN PE=3 SV=1
4.0E-51 [10..367] [103..436]
gi|18859035, gi|... - gi|18859035|ref|NP_571922.1| microphthalmia-associated transcription factor b [Danio rerio], gi|1534...
5.0E-51 [23..413] [34..426]

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Predicted Domain #1
Region A:
Residues: [1-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNFQKPFSG SSDGNSVMND LGNKVAIKVF DCRSAQDGSE EQNVNVTTNQ MYLMFQSNNY  60
   61 NVPPPNYNTE DLGSQGPPTH AYYAPFQHPI HLQPPVPPVY KNNTYSATDQ YSDSSFPNTS 120
  121 GHTPVIDSNY YNDALASIPT TTTGSTTMTT DNGNTIDSEE YIDNMEVFSS EENENIDNVK 180
  181 QTDLKSEKDS SLLSAASIVK KEQLSGFENF LPLSKTESPL VTADEIKSSL NLENIDNADS 240
  241 MSFKLKTSPI RKHFHVKPKR ITR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [264-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRTGRVSHNI IEKKYRSNIN DKIEQLRRTV PTLRVAYKKC NDLPITSRDL ADLDGLEPAT  60
   61 KLNKASILTK SIEYICHLER KCLQLSLANQ HLSNDTRDSF VHLTEPSQPL SDNSSSEQVQ 120
  121 KQTRSCQRQR QRQPRQQQPL HNIQYNIPHQ NGLMSGTNNS HDMDFNNAGD F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1am9A_
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.71844613492852 bayes_pls_golite062009
DNA binding 1.86563747084791 bayes_pls_golite062009
transcription regulator activity 1.821185547269 bayes_pls_golite062009
nucleic acid binding 1.7383733164042 bayes_pls_golite062009
transcription factor activity 1.60036420700371 bayes_pls_golite062009
protein binding 1.2438981435533 bayes_pls_golite062009
transcription factor binding 0.181447848144379 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle