| Protein: | TOP1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 769 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOP1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..769] | [1..769] |
|
|
0.0 | [5..767] | [43..812] |
|
|
0.0 | [5..767] | [41..810] |
|
|
0.0 | [5..769] | [220..911] |
|
|
0.0 | [1..769] | [90..871] |
|
|
0.0 | [43..769] | [42..763] |
|
|
0.0 | [14..769] | [28..778] |
|
Region A: Residues: [1-123] |
1 11 21 31 41 51
| | | | | |
1 MTIADASKVN HELSSDDDDD VPLSQTLKKR KVASMNSASL QDEAEPYDSD EAISKISKKK 60
61 TKKIKTEPVQ SSSLPSPPAK KSATSKPKKI KKEDGDVKVK TTKKEEQENE KKKREEEEEE 120
121 DKK
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.245 | 0.033 | regulation of mitotic recombination | d.110.4 | SNARE-like |
| View | Download | 0.317 | 0.025 | regulation of mitotic recombination | a.24.11 | Bacterial GAP domain |
| View | Download | 0.245 | 0.024 | DNA topoisomerase type I activity | d.110.4 | SNARE-like |
| View | Download | 0.317 | 0.019 | DNA topoisomerase type I activity | a.24.11 | Bacterial GAP domain |
| View | Download | 0.368 | 0.010 | regulation of mitotic recombination | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.368 | 0.007 | DNA topoisomerase type I activity | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.206 | 0.006 | regulation of mitotic recombination | a.94.1 | Ribosomal protein L19 (L19e) |
| View | Download | 0.206 | 0.004 | DNA topoisomerase type I activity | a.94.1 | Ribosomal protein L19 (L19e) |
| View | Download | 0.226 | N/A | N/A | a.182.1 | GatB/YqeY domain |
|
Region A: Residues: [124-158] |
1 11 21 31 41 51
| | | | | |
1 AKEEEEEYKW WEKENEDDTI KWVTLKHNGV IFPPP
|
|
Region B: Residues: [253-290] |
1 11 21 31 41 51
| | | | | |
1 SQEKKQIRLE REKFEEDYKF CELDGRREQV GNFKVEPP
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|
Region C: Residues: [307-366] |
1 11 21 31 41 51
| | | | | |
1 RRVNPEDIVL NLSKDAPVPP APEGHKWGEI RHDNTVQWLA MWRENIFNSF KYVRLAANSS 60
61
|
| Detection Method: | |
| Confidence: | 1352.0 |
| Match: | 1ois__ |
| Description: | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| catalytic activity | 0.078956976886834 | bayes_pls_golite062009 |
|
Region A: Residues: [159-252] |
1 11 21 31 41 51
| | | | | |
1 YQPLPSHIKL YYDGKPVDLP PQAEEVAGFF AALLESDHAK NPVFQKNFFN DFLQVLKESG 60
61 GPLNGIEIKE FSRCDFTKMF DYFQLQKEQK KQLT
|
|
Region B: Residues: [291-306] |
1 11 21 31 41 51
| | | | | |
1 DLFRGRGAHP KTGKLK
|
| Detection Method: | |
| Confidence: | 1352.0 |
| Match: | 1ois__ |
| Description: | Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [367-480] |
1 11 21 31 41 51
| | | | | |
1 LKGQSDYKKF EKARQLKSYI DAIRRDYTRN LKSKVMLERQ KAVAIYLIDV FALRAGGEKS 60
61 EDEADTVGCC SLRYEHVTLK PPNTVIFDFL GKDSIRFYQE VEVDKQVFKN LTIF
|
| Detection Method: | |
| Confidence: | 57.9794 |
| Match: | 1a41__ |
| Description: | Eukaryotic DNA topoisomerase I, catalytic core |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [481-534] |
1 11 21 31 41 51
| | | | | |
1 KRPPKQPGHQ LFDRLDPSIL NKYLQNYMPG LTAKVFRTYN ASKTMQDQLD LIPN
|
| Detection Method: | |
| Confidence: | 3.221849 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [535-615] |
1 11 21 31 41 51
| | | | | |
1 KGSVAEKILK YNAANRTVAI LCNHQRTVTK GHAQTVEKAN NRIQELEWQK IRCKRAILQL 60
61 DKDLLKKEPK YFEEIDDLTK E
|
| Detection Method: | |
| Confidence: | 3.221849 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [616-719] |
1 11 21 31 41 51
| | | | | |
1 DEATIHKRII DREIEKYQRK FVRENDKRKF EKEELLPESQ LKEWLEKVDE KKQEFEKELK 60
61 TGEVELKSSW NSVEKIKAQV EKLEQRIQTS SIQLKDKEEN SQVS
|
| Detection Method: | |
| Confidence: | 3.221849 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [720-769] |
1 11 21 31 41 51
| | | | | |
1 LGTSKINYID PRLSVVFCKK YDVPIEKIFT KTLREKFKWA IESVDENWRF
|
| Detection Method: | |
| Confidence: | 12.79 |
| Match: | 1a36A |
| Description: | Eukaryotic DNA topoisomerase I, dispensable insert domain; Eukaryotic DNA topoisomerase I, catalytic core; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
Matching Structure (courtesy of the PDB): |
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