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Protein Overview: top1

General Information:
Name(s) found: top1 / SPBC1703.14c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • DNA topoisomerase I [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 814 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    nuclear chromatin [NASLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: mitotic chromosome condensation [ISSLink to PubMed article]
    transcription of nuclear rRNA large RNA polymerase I transcript [IGILink to PubMed article]
    chromatin assembly or disassembly [ISSLink to PubMed article]
    DNA topological change [IMPLink to PubMed article]
    chromatin organization [IGILink to PubMed article]
    DNA unwinding involved in replication [IEA]
    Molecular Function: ATP binding [IEA]
    DNA topoisomerase type I activity [ISSLink to PubMed article]
    DNA topoisomerase (ATP-hydrolyzing) activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSDSDSVS LSIRRRQRRG SSKRISMKES DEESDSSENH PLSESLNKKS KSESDEDDIP  60
   61 IRKRRASSKK NMSNSSSKKR AKVMGNGGLK NGKKTAVVKE EEDFNEIAKP SPKHKRVSKA 120
  121 NGSKNGAKSA VKKEESDTDD SVPLRAVSTV SLTPYKSELP SGASTTQNRS PNDEEDEDED 180
  181 YKWWTSENID DTQKWTTLEH NGVIFAPPYE PLPKNVKLIY DGNPVNLPPE AEEVAGFYAA 240
  241 MLETDHAKNP VFQDNFFRDF LKVCDECNFN HNIKEFSKCD FTQMFHHFEQ KREEKKSMPK 300
  301 EQKKAIKQKK DEEEEKYKWC ILDGRKEKVG NFRIEPPGLF RGRGSHPKTG SLKRRVYPEQ 360
  361 ITINIGEGVP VPEPLPGHQW AEVKHDNTVT WLATWHENIN NNVKYVFLAA GSSLKGQSDL 420
  421 KKYEKSRKLK DYIDDIRKGY RKDLKSELTV ERQRGTAMYL IDVFALRAGN EKGEDEADTV 480
  481 GCCSLRYEHV TLKPPRTVVF DFLGKDSIRY YNEVEVDPQV FKNLKIFKRP PKKEGDLIFD 540
  541 RLSTNSLNKY LTSLMDGLSA KVFRTYNASY TMAEELKKMP KNLTLADKIL FYNRANRTVA 600
  601 ILCNHQRSVT KNHDVQMERF AERIKALQYQ RMRLRKMMLN LEPKLAKSKP ELLAKEEGIT 660
  661 DSWIVKHHET LYELEKEKIK KKFDRENEKL AAEDPKSVLP ESELEVRLKA ADELKKALDA 720
  721 ELKSKKVDPG RSSMEQLEKR LNKLNERINV MRTQMIDKDE NKTTALGTSK INYIDPRLTY 780
  781 SFSKREDVPI EKLFSKTIRD KFNWAADTPP DWKW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] FFAS03 1.34 No description for 2j63A was found.
    2 View Details [192..722] PSI-BLAST 171.0 Eukaryotic DNA topoisomerase I, catalytic core; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    3 View Details [723..814] PSI-BLAST 21.0 Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle