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View Structure Prediction Details

Protein: ATG4
Organism: Saccharomyces cerevisiae
Length: 506 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG4.

Description E-value Query
Range
Subject
Range
ATG4_YEAS7 - Cysteine protease ATG4 OS=Saccharomyces cerevisiae (strain YJM789) GN=ATG4 PE=3 SV=1
ATG4_YEAST - Cysteine protease ATG4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG4 PE=1 SV=2
gi|190409197 - gi|190409197|gb|EDV12462.1| anchor protein [Saccharomyces cerevisiae RM11-1a]
ATG4 - Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagoso...
0.0 [13..506] [1..494]
gi|14042685 - gi|14042685|dbj|BAB55353.1| unnamed protein product [Homo sapiens]
0.0 [83..401] [25..358]
gi|220955642, gi... - gi|220955642|gb|ACL90364.1| Atg4-PA [synthetic construct], gi|220945806|gb|ACL85446.1| Atg4-PA [synt...
Atg4-PA - The gene Autophagy-specific gene 4 is referred to in FlyBase by the symbol Dmel\Atg4 (CG4428, FBgn00...
0.0 [84..409] [50..362]
atg-4.2 - status:Partially_confirmed UniProt:Q9U1N6 protein_id:CAB54515.1
9.0E-94 [87..397] [151..475]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDFLSRIGV IYMQRWLQLW KMDLVQKVSH GVFEGSSEEP AALMNHDYIV LGEVYPERDE  60
   61 ESGAEQCEQD CRYRGEAVSD GFLSSLFGRE ISSYTKEFLL DVQSRVNFTY RTRFVPIARA 120
  121 PD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.274 a.4.5 "Winged helix" DNA-binding domain
View Download 0.293 a.1.1 Globin-like
View Download 0.402 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.270 g.53.1 TAZ domain
View Download 0.232 a.130.1 Chorismate mutase II
View Download 0.201 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5

Predicted Domain #2
Region A:
Residues: [123-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPSPLSLNLL VRTNPISTIE DYIANPDCFN TDIGWGCMIR TGQSLLGNAL QILHLGRDFR  60
   61 VNGNESLERE SKFVNWFNDT PEAPFSLHNF VSAGTELSDK RPGEWFGPAA TARSIQSLIY 120
  121 GFPECGIDDC IVSVSSGDIY ENEVEKVFAE NPNSRILFLL GVKLGINAVN ESYRESICGI 180
  181 LSSTQSVGIA GGRPSSSLYF FGYQGNEFLH FDPHIPQPAV EDSFVESCHT SKFGKLQLSE 240
  241 MDPSMLIGIL IKGEKDWQQW KLEVAESAII NVLAKRMDDF DVSCSMDDVE SVSSNSMKKD 300
  301 ASNNENLGVL EGDYVDIGAI FPH

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 170.443697
Match: PF03416
Description: Peptidase family C54

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [446-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTNTEDVDEY DCFQDIHCKK QKIVVMGNTH TVNANLTDYE VEGVLVEKET VGIHSPIDEK  60
   61 C

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.601 g.3.11 EGF/Laminin
View Download 0.691 g.18.1 Complement control module/SCR domain
View Download 0.530 d.58.17 Metal-binding domain
View Download 0.511 b.34.1 C-terminal domain of transcriptional repressors
View Download 0.598 g.44.1 RING/U-box
View Download 0.476 d.52.1 Alpha-lytic protease prodomain
View Download 0.470 b.71.1 Glycosyl hydrolase domain
View Download 0.432 d.58.38 Urease metallochaperone UreE, C-terminal domain
View Download 0.427 g.27.1 Fibronectin type I module
View Download 0.394 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.359 b.34.3 Myosin S1 fragment, N-terminal domain
View Download 0.344 d.58.49 YajQ-like
View Download 0.337 d.82.1 Copper amine oxidase, domain N
View Download 0.300 b.72.1 WW domain
View Download 0.290 d.58.3 Protease propeptides/inhibitors
View Download 0.254 g.27.1 Fibronectin type I module
View Download 0.252 d.19.1 MHC antigen-recognition domain
View Download 0.238 b.7.2 Periplasmic chaperone C-domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle