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Protein Overview: ATG4

General Information:
Name(s) found: ATG4 / YNL223W [SGD]
Description(s) found:
Found 12 descriptions.
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  • Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 506 amino acids

    Gene Ontology:
    Cellular Component: microtubule associated complex [IPILink to PubMed article]
    Biological Process: autophagy [IGILink to PubMed article][IMPLink to PubMed article]
    C-terminal protein lipidation [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]
    microtubule binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDFLSRIGV IYMQRWLQLW KMDLVQKVSH GVFEGSSEEP AALMNHDYIV LGEVYPERDE  60
   61 ESGAEQCEQD CRYRGEAVSD GFLSSLFGRE ISSYTKEFLL DVQSRVNFTY RTRFVPIARA 120
  121 PDGPSPLSLN LLVRTNPIST IEDYIANPDC FNTDIGWGCM IRTGQSLLGN ALQILHLGRD 180
  181 FRVNGNESLE RESKFVNWFN DTPEAPFSLH NFVSAGTELS DKRPGEWFGP AATARSIQSL 240
  241 IYGFPECGID DCIVSVSSGD IYENEVEKVF AENPNSRILF LLGVKLGINA VNESYRESIC 300
  301 GILSSTQSVG IAGGRPSSSL YFFGYQGNEF LHFDPHIPQP AVEDSFVESC HTSKFGKLQL 360
  361 SEMDPSMLIG ILIKGEKDWQ QWKLEVAESA IINVLAKRMD DFDVSCSMDD VESVSSNSMK 420
  421 KDASNNENLG VLEGDYVDIG AIFPHTTNTE DVDEYDCFQD IHCKKQKIVV MGNTHTVNAN 480
  481 LTDYEVEGVL VEKETVGIHS PIDEKC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] deduced N/A No confident structure predictions are available.
    2 View Details [123..445] Pfam 170.443697 Peptidase family C54 No confident structure predictions are available.
    3 View Details [446..506] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle