YRC Public Data Repository - Protein Structure Prediction

Protein:	AAH1
Organism:	Saccharomyces cerevisiae
Length:	347 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAH1.

Description	E-value	Query Range	Subject Range
gi\|207341772 - gi\|207341772\|gb\|EDZ69736.1\| YNL141Wp-like protein [Saccharomyces cerevisiae AWRI1631] ADE_YEAST - Adenine deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AAH1 PE=1 SV=1 AAH1 - Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine sal... gi\|151944396 - gi\|151944396\|gb\|EDN62674.1\| adenine aminohydrolase [Saccharomyces cerevisiae YJM789] gi\|190409127 - gi\|190409127\|gb\|EDV12392.1\| adenine aminohydrolase [Saccharomyces cerevisiae RM11-1a]	4.0E-84	[1..347]	[1..347]
ADA_BOVIN - Adenosine deaminase OS=Bos taurus GN=ADA PE=1 SV=3	7.0E-82	[9..342]	[8..351]
ADA_RAT - Adenosine deaminase OS=Rattus norvegicus GN=Ada PE=1 SV=3	6.0E-81	[9..343]	[8..352]
ADA - adenosine deaminase gi\|123984523, gi... - gi\|123998497\|gb\|ABM86850.1\| adenosine deaminase [synthetic construct], gi\|123984523\|gb\|ABM83607.1\| a...	1.0E-80	[10..342]	[9..351]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	2.0E-80	[10..342]	[9..351]
ADE_SCHPO - Adenine deaminase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=aah1 PE=1 SV=1 dea2 - adenine deaminase Dea2	6.0E-80	[6..346]	[9..350]
ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 /... ADD_CLOAB - Adenosine deaminase OS=Clostridium acetobutylicum GN=add PE=3 SV=1	4.0E-79	[1..339]	[1..334]
gi\|13361798, gi\|... - gi\|15831585\|ref\|NP_310358.1\| adenosine deaminase [Escherichia coli O157:H7 str. Sakai], gi\|13361798\|... gi\|254592639, gi... - gi\|254793239\|ref\|YP_003078076.1\| adenosine deaminase [Escherichia coli O157:H7 str. TW14359], gi\|254... ADD_ECO5E - Adenosine deaminase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=add PE=3 SV=1 gi\|217318390, gi... - gi\|217329043\|ref\|ZP_03445124.1\| adenosine deaminase [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|195939010 - gi\|195939010\|ref\|ZP_03084392.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4024] gi\|208725171, gi... - gi\|208810655\|ref\|ZP_03252531.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4206], gi\|20872... gi\|208731266, gi... - gi\|208816923\|ref\|ZP_03258043.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|208741887, gi... - gi\|208821764\|ref\|ZP_03262084.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4042], gi\|20874... gi\|168775851, gi... - gi\|187768651\|gb\|EDU32495.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4196], gi\|168775851... gi\|188999224, gi... - gi\|188999224\|gb\|EDU68210.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4076], gi\|168783444... gi\|168789458, gi... - gi\|189370953\|gb\|EDU89369.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC869], gi\|168789458\|... gi\|189376896, gi... - gi\|189376896\|gb\|EDU95312.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC508], gi\|168800881\|... gi\|168750565, gi... - gi\|188015257\|gb\|EDU53379.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4113], gi\|168750565... gi\|189355519, gi... - gi\|189355519\|gb\|EDU73938.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4401], gi\|168757463... gi\|189366196, gi... - gi\|189366196\|gb\|EDU84612.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4501], gi\|168763675... gi\|168771163, gi... - gi\|189360022\|gb\|EDU78441.1\| adenosine deaminase [Escherichia coli O157:H7 str. EC4486], gi\|168771163... ADD_ECO57 - Adenosine deaminase OS=Escherichia coli O157:H7 GN=add PE=3 SV=1 gi\|15802037, gi\|... - gi\|15802037\|ref\|NP_288059.1\| adenosine deaminase [Escherichia coli O157:H7 EDL933], gi\|12515612\|gb\|A... gi\|209769726, gi... - pir\|\|H85768 adenosine deaminase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), p...	1.0E-77	[10..338]	[6..330]
ADA_MOUSE - Adenosine deaminase OS=Mus musculus GN=Ada PE=1 SV=3	1.0E-77	[9..343]	[8..352]

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Predicted Domain #1

Region A:
Residues: [1-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSVEFLQEL PKCEHHLHLE GTLEPDLLFP LAKRNDIILP EGFPKSVEEL NEKYKKFRDL  60
   61 QDFLDYYYIG TNVLISEQDF FDLAWAYFKK VHKQGLVHAE VFYDPQSHTS RGISIETVTK 120
  121 GFQRACDKAF SEFGITSKLI MCLLRHIEPE ECLKTIEEAT PFIKDGTISA LGLDSAEKPF 180
  181 PPHLFVECYG KAASLNKDLK LTAHAGEEGP AQFVSDALDL LQVTRIDHGI NSQYDEELLD 240
  241 RLSRDQTMLT ICPLSNVKLQ VVQSVSELPL QKFLDRDVPF SLNSDDPAYF GGYILDVYTQ 300
  301 VSKDFPHWDH ETWGRIAKNA IKGSWCDDKR KNGLLSRVDE VVTKYSH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	308.38764
Match:	1m7mA_
Description:	No description for 1m7mA_ was found.

Predicted functions:

Term	Confidence	Notes
purine nucleoside binding	5.77008212157543	bayes_pls_golite062009
adenosine deaminase activity	4.58148305437166	bayes_pls_golite062009
adenine deaminase activity	3.70002828902508	bayes_pls_golite062009
hydrolase activity	3.62199995345412	bayes_pls_golite062009
dihydropyrimidinase activity	3.41635858763209	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
binding	1.20793368650496	bayes_pls_golite062009
protein binding	0.928500526896831	bayes_pls_golite062009
guanine deaminase activity	0.861706835095856	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.787370269329878	bayes_pls_golite062009
nucleic acid binding	0.629962267754185	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
transcription regulator activity	0.530552339840648	bayes_pls_golite062009
DNA binding	0.462348875991261	bayes_pls_golite062009
glycosaminoglycan binding	0.408989331337656	bayes_pls_golite062009
peptidase activity	0.356051335471361	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: