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View Structure Prediction Details

Protein: APJ1
Organism: Saccharomyces cerevisiae
Length: 528 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APJ1.

Description E-value Query
Range		 Subject
Range
APJ1_YEAST - J domain-containing protein APJ1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APJ1 PE...
APJ1 - Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Ps...
 0.0 [1..528] [1..528]
DNAJ_GEOSE - Chaperone protein DnaJ OS=Geobacillus stearothermophilus GN=dnaJ PE=3 SV=1
 3.0E-85 [1..450] [1..380]
DNAJ_GEOTM - Chaperone protein DnaJ OS=Geobacillus thermoglucosidasius GN=dnaJ PE=3 SV=1
 1.0E-79 [1..333] [1..346]
DNAJ_AGRFC - Chaperone protein DnaJ OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=dnaJ PE=2 SV=2
gi|25296037, gi|... - pir||AD2591 molecular chaperone, DnaJ family dnaJ [imported] - Agrobacterium tumefaciens (strain C58...
 1.0E-78 [1..333] [1..346]
DNAJA3 - DnaJ (Hsp40) homolog, subfamily A, member 3
 2.0E-78 [4..376] [91..460]
DNAJ_RHIME - Chaperone protein DnaJ OS=Rhizobium meliloti (strain 1021) GN=dnaJ PE=3 SV=1
DNAJ_RHIME - Chaperone protein dnaJ OS=Rhizobium meliloti GN=dnaJ PE=3 SV=1
 4.0E-78 [4..333] [2..345]
gi|12836451 - gi|12836451|dbj|BAB23661.1| unnamed protein product [Mus musculus]
 2.0E-77 [6..373] [93..457]

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Predicted Domain #1
Region A:
Residues: [1-129] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNTSLYDS LNVTAAASTS EIKKAYRNAA LKYHPDKNNH TEESKRKFQE ICQAYEILKD  60
   61 NRLRALYDQY GTTDEVLIQE QQAQAQRQQA GPFSSSSNFD TEAMSFPDLS PGDLFAQFFN 120
  121 SSATPSSNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 159.855515
Match: 1bq0__
Description: DnaJ chaperone, N-terminal (J) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 3.04403163860617 bayes_pls_golite062009
binding 2.63138872417193 bayes_pls_golite062009
heat shock protein binding 2.17994194200939 bayes_pls_golite062009
transcription regulator activity 1.91297632253219 bayes_pls_golite062009
nucleic acid binding 1.6342534817623 bayes_pls_golite062009
chaperone binding 1.61155546076854 bayes_pls_golite062009
protein binding 1.60937254813642 bayes_pls_golite062009
DNA binding 1.55234338199368 bayes_pls_golite062009
Hsp70 protein binding 0.541755903922701 bayes_pls_golite062009
catalytic activity 0.106988907594358 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [130-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKSSFNFSFN NSSTPSFSFV NGSGVNNLYS SSAKYNSNDE DHHLDRGPDI KHNLKCTLKE  60
   61 LYMGKTAKLG LNRTRICSVC DGHGGLKKCT CKTCKGQGIQ TQTRRMGPLV QSWSQTCADC 120
  121 GGAGVFVKNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0103
Match: 1exkA_
Description: Cysteine-rich domain of the chaperone protein DnaJ.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.7298921704023 bayes_pls_golite062009
protein disulfide isomerase activity 2.4409950647303 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 2.4409950647303 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 2.23398279564144 bayes_pls_golite062009
unfolded protein binding 2.04158808514315 bayes_pls_golite062009
protein binding 1.57926302986794 bayes_pls_golite062009
catalytic activity 0.276917867171685 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [260-457] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DICQQCQGLG FIKERKILQV TVQPGSCHNQ LIVLTGEGDE VISTKGGGHE KVIPGDVVIT  60
   61 ILRLKDPNFQ VINYSNLICK KCKIDFMTSL CGGVVYIEGH PSGKLIKLDI IPGEILKPGC 120
  121 FKTVEDMGMP KFINGVRSGF GHLYVKFDVT YPERLEPENA KKIQNILAND KYIKAERSTM 180
  181 ETADSDCYCD LEKSYDSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1c3gA_
Description: Heat shock protein 40 Sis1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [458-528] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEHVLSSFEA PNLNNEVIED DDLGDLINER DSRKRNNRRF DESNINNNNE TKRNKYSSPV  60
   61 SGFYDHDING Y

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.209 a.61.1 Retroviral matrix proteins
View Download 0.485 a.76.1 Iron-dependent represor protein, dimerization domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle