YRC Public Data Repository - Protein Structure Prediction

Protein:	PRE5
Organism:	Saccharomyces cerevisiae
Length:	234 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE5.

Description	E-value	Query Range	Subject Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	4.0E-79	[3..234]	[7..234]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	3.0E-78	[3..234]	[7..234]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	1.0E-77	[3..234]	[7..234]
gi\|286250 - gi\|286250\|dbj\|BAA01587.1\| proteasome subunit R-IOTA [Rattus sp.] gi\|67969980 - gi\|67969980\|dbj\|BAE01337.1\| unnamed protein product [Macaca fascicularis] PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6 PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 gi\|55640605, gi\|... - gi\|55640605\|ref\|XP_509906.1\| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi\|1... gi\|109083327, gi... - gi\|109083327\|ref\|XP_001086524.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i... gi\|149692835 - gi\|149692835\|ref\|XP_001491320.1\| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus] ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000... PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1 gi\|123983062 - gi\|123983062\|gb\|ABM83272.1\| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr... gi\|222154129 - gi\|222154129\|gb\|ACM47241.1\| proteasome subunit alpha type 6 [Capra hircus] tr\|M3WV20\|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1	2.0E-76	[1..234]	[1..239]
PSA6_MOUSE - Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1	9.0E-76	[1..234]	[1..239]
gi\|3421092, gi\|2... - gi\|3421092\|gb\|AAC32062.1\| 20S proteasome subunit PAF1 [Arabidopsis thaliana], pir\|\|T51974 C 3.4.25.1...	3.0E-75	[1..234]	[1..232]

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Predicted Domain #1

Region A:
Residues: [1-234]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRNNYDGDT VTFSPTGRLF QVEYALEAIK QGSVTVGLRS NTHAVLVALK RNADELSSYQ  60
   61 KKIIKCDEHM GLSLAGLAPD ARVLSNYLRQ QCNYSSLVFN RKLAVERAGH LLCDKAQKNT 120
  121 QSYGGRPYGV GLLIIGYDKS GAHLLEFQPS GNVTELYGTA IGARSQGAKT YLERTLDTFI 180
  181 KIDGNPDELI KAGVEAISQS LRDESLTVDN LSIAIVGKDT PFTIYDGEAV AKYI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1389.522879
Match:	1fntF_
Description:	CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: