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View Structure Prediction Details

Protein: PRE5
Organism: Saccharomyces cerevisiae
Length: 234 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE5.

Description E-value Query
Range
Subject
Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1
PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1
4.0E-79 [3..234] [7..234]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ...
PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1
3.0E-78 [3..234] [7..234]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p...
PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1
1.0E-77 [3..234] [7..234]
gi|286250 - gi|286250|dbj|BAA01587.1| proteasome subunit R-IOTA [Rattus sp.]
gi|67969980 - gi|67969980|dbj|BAE01337.1| unnamed protein product [Macaca fascicularis]
PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6
PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1
gi|55640605, gi|... - gi|55640605|ref|XP_509906.1| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi|1...
gi|109083327, gi... - gi|109083327|ref|XP_001086524.1| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i...
gi|149692835 - gi|149692835|ref|XP_001491320.1| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus]
ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000...
PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1
gi|123983062 - gi|123983062|gb|ABM83272.1| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr...
gi|222154129 - gi|222154129|gb|ACM47241.1| proteasome subunit alpha type 6 [Capra hircus]
tr|M3WV20|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1
2.0E-76 [1..234] [1..239]
PSA6_MOUSE - Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1
9.0E-76 [1..234] [1..239]
gi|3421092, gi|2... - gi|3421092|gb|AAC32062.1| 20S proteasome subunit PAF1 [Arabidopsis thaliana], pir||T51974 C 3.4.25.1...
3.0E-75 [1..234] [1..232]

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Predicted Domain #1
Region A:
Residues: [1-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRNNYDGDT VTFSPTGRLF QVEYALEAIK QGSVTVGLRS NTHAVLVALK RNADELSSYQ  60
   61 KKIIKCDEHM GLSLAGLAPD ARVLSNYLRQ QCNYSSLVFN RKLAVERAGH LLCDKAQKNT 120
  121 QSYGGRPYGV GLLIIGYDKS GAHLLEFQPS GNVTELYGTA IGARSQGAKT YLERTLDTFI 180
  181 KIDGNPDELI KAGVEAISQS LRDESLTVDN LSIAIVGKDT PFTIYDGEAV AKYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1389.522879
Match: 1fntF_
Description: CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
endopeptidase activity 6.91642761177919 bayes_pls_golite062009
peptidase activity 6.84511694091156 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 6.5973571808298 bayes_pls_golite062009
hydrolase activity 4.47652590304822 bayes_pls_golite062009
threonine-type endopeptidase activity 2.98214579292788 bayes_pls_golite062009
threonine-type peptidase activity 2.98214579292788 bayes_pls_golite062009
binding 1.75265921676176 bayes_pls_golite062009
nucleic acid binding 1.39216781236247 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle