YRC Public Data Repository - Protein Structure Prediction

Protein:	TGL3
Organism:	Saccharomyces cerevisiae
Length:	642 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TGL3.

Description	E-value	Query Range	Subject Range
TGL3_YEAST - Lipase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TGL3 PE=1 SV=2 TGL3 - Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase act...	0.0	[1..642]	[1..642]
SDP1_ARATH - Triacylglycerol lipase SDP1 OS=Arabidopsis thaliana GN=SDP1 PE=1 SV=1	5.0E-96	[18..444]	[45..462]
gi\|20804680, gi\|... - gi\|50902030\|ref\|XP_463448.1\| P0512C01.22 [Oryza sativa (japonica cultivar-group)], gi\|20804680\|dbj\|B...	1.0E-85	[59..479]	[89..492]
YCKG_SCHPO - Uncharacterized protein C1450.16c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1450... SPCC1450.16c - triacylglycerol lipase	5.0E-85	[22..450]	[7..407]
gi\|205339686, gi... - gi\|205339686\|gb\|EDZ26450.1\| phospholipase, patatin family [Salmonella enterica subsp. enterica serov... gi\|194450925, gi... - gi\|194450925\|ref\|YP_002045799.1\| hypothetical protein SeHA_C1944 [Salmonella enterica subsp. enteric... gi\|161363117, gi... - gi\|161613753\|ref\|YP_001587718.1\| hypothetical protein SPAB_01487 [Salmonella enterica subsp. enteric... gi\|205327536, gi... - gi\|205327536\|gb\|EDZ14300.1\| phospholipase, patatin family [Salmonella enterica subsp. enterica serov... gi\|56127579, gi\|... - gi\|56413322\|ref\|YP_150397.1\| hypothetical protein SPA1124 [Salmonella enterica subsp. enterica serov... gi\|16765098, gi\|... - gi\|16765098\|ref\|NP_460713.1\| hypothetical protein STM1754 [Salmonella typhimurium LT2], gi\|16420286\|... lcl\|NC_016856.1_... - [gene=ychK] [protein=hypothetical protein] [protein_id=YP_005237682.1] [location=complement(1860732.... gi\|200390353, gi... - gi\|200390353\|ref\|ZP_03216964.1\| phospholipase, patatin family [Salmonella enterica subsp. enterica s... gi\|197266035, gi... - gi\|197266035\|ref\|ZP_03166109.1\| phospholipase, patatin family [Salmonella enterica subsp. enterica s... gi\|197093724, gi... - gi\|197362247\|ref\|YP_002141884.1\| hypothetical protein SSPA1043 [Salmonella enterica subsp. enterica ...	1.0E-63	[201..507]	[5..271]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKETAQEYKV SAVIPTLLKN WILRVVYATL DHIPPFVWEI LHVITDIYFF WVQKLINYVR  60
   61 PHSRVIYYNA IKKLDECDTY QMWCQQASVV DEITGANLWR RNFFSRRYDF NSVIEQYSIL 120
  121 ENMLREEKYD VVKEKFSTTG PCMLRNFAGI GDKKLFTKSL MGTKLLIEQY LTRILEGLDI 180
  181 LNNQT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [186-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPTSFFQRC KLSLGTTALI LQGGSLFGLF HLGVIRGLLL QDLMPNIISG SSMGACVASL  60
   61 FGCLSNEQLK QLLTDDNLLN IIKNDVDLLK SCGYGNLEQH LNLGTLIQNL IHHGYSQDVY 120
  121 LFIRFVMKYI VKEKTFEEVY QITGKVFNIV IHPTDKSCPN LLNYVTTPNV LIKSAIECSL 180
  181 GSGVISEDTS LLCKNLENEI EPFLNINKNK QVKFLTPENA NNPSITE

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	5.443697
Match:	PF01734
Description:	Patatin-like phospholipase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [413-642]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYTRLTELF NVNNFIVSLA RPYLAPLVVN DLKHEIKTSK YYYYKHYPNM PPINANTVRK  60
   61 TQRSSSQSPI KAGTVEDLEP EPLMSPVPPS SAVNDSAEYI IPELGIPQLN FTEMEPLAFK 120
  121 FKYHLERKLK NIATMEFRHR MEVLDNLGLL CSLIKRLIID EKTPRSATEI AVVPRMKSLS 180
  181 LTRIIEGQLN NIPYWIKSGE RSTWPALALI KTRCAVEFKL DDIIRARRSR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phospholipase A2 activity	2.22630563405125	bayes_pls_golite062009
phospholipase activity	2.02363770793596	bayes_pls_golite062009
lipase activity	1.83391969295473	bayes_pls_golite062009
catalytic activity	1.681309422157	bayes_pls_golite062009
[acyl-carrier-protein] S-malonyltransferase activity	1.27314027329282	bayes_pls_golite062009
S-malonyltransferase activity	1.27314027329282	bayes_pls_golite062009
malonyltransferase activity	1.27314027329282	bayes_pls_golite062009
hydrolase activity	0.755660272658182	bayes_pls_golite062009
fatty acid synthase activity	0.432469017757431	bayes_pls_golite062009
carboxylesterase activity	0.431665185524913	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.39017969987234	bayes_pls_golite062009
S-acyltransferase activity	0.28475890150768	bayes_pls_golite062009
binding	0.112552746544258	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [413-507]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYTRLTELF NVNNFIVSLA RPYLAPLVVN DLKHEIKTSK YYYYKHYPNM PPINANTVRK  60
   61 TQRSSSQSPI KAGTVEDLEP EPLMSPVPPS SAVND

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [508-642]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAEYIIPELG IPQLNFTEME PLAFKFKYHL ERKLKNIATM EFRHRMEVLD NLGLLCSLIK  60
   61 RLIIDEKTPR SATEIAVVPR MKSLSLTRII EGQLNNIPYW IKSGERSTWP ALALIKTRCA 120
  121 VEFKLDDIIR ARRSR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: