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View Structure Prediction Details

Protein: CAT8
Organism: Saccharomyces cerevisiae
Length: 1433 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAT8.

Description E-value Query
Range		 Subject
Range
gi|1122901 - gi|1122901|emb|CAA63906.1| MSP8 [Saccharomyces cerevisiae]
 0.0 [1..1433] [1..1429]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..1431] [103..1443]
gi|7021392 - gi|7021392|gb|AAF35321.1|AF222908_1 Cat8 [Candida albicans]
 0.0 [22..1034] [7..989]
XLNR_ASPFN - Xylanolytic transcriptional activator xlnR OS=Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / ...
XLNR_ASPOR - Xylanolytic transcriptional activator xlnR OS=Aspergillus oryzae GN=xlnR PE=1 SV=2
XLNR_ASPOR - Xylanolytic transcriptional activator xlnR OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=xln...
 3.0E-65 [8..709] [64..766]

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Predicted Domain #1
Region A:
Residues: [1-192] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANNNSDRQG LEPRVIRTLG SQALSGPSIS NRTSSSEANP HFSKNVKEAM IKTASPTPLS  60
   61 TPIYRIAQAC DRCRSKKTRC DGKRPQCSQC AAVGFECRIS DKLLRKAYPK GYTESLEERV 120
  121 RELEAENKRL LALCDIKEQQ ISLVSQSRPQ TSTDNTINGN FKHDLKDAPL NLSSTNIYLL 180
  181 NQTVNKQLQN GK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.144602
Match: 1d66A_
Description: Gal4; CD2-Gal4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [193-332] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGDNSGSAM SPLGAPPPPP HKDHLCDGVS CTNHLHVKPT STSLNDPTAI SFEQDEAPGL  60
   61 PAVKALKSMT THQRSTQLAT LVSLSIPRST EEILFIPQLL TRIRQIFGFN SKQCLYTVSL 120
  121 LSSLKNRLPA PRLLAPSTST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.253 0.242 positive regulation of transcription from RNA polymerase II promoter a.1.1 Globin-like
View Download 0.688 0.083 positive regulation of transcription from RNA polymerase II promoter a.40.1 Calponin-homology domain, CH-domain
View Download 0.254 0.003 positive regulation of transcription from RNA polymerase II promoter a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.250 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.215 N/A N/A d.95.2 Homing endonucleases
View Download 0.204 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #3
Region A:
Residues: [333-853] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLKEKDEDKK LDDDSAFVKR FQSTNLSEFV DLKKFLISLK FNINSFSKQS EKPANDQDDE  60
   61 LLSLTEIKEL LHLFFKFWSN QVPILNNDHF LIYFNNFVEV VKHLSTENLE TNNTTKSTVT 120
  121 TNHEIFALKL LMMLQMGLLV KIKMEKIKYT VPKNPKAKYA RLMAYYHQLS LIIPKNPYFL 180
  181 NMSTTSLPSL QLLSLASFYY LNVGDISAIY GVRGRIVSMA QQLRLHRCPS AVLSVHSNPV 240
  241 LQKFEQSERR LLFWAIYYVD VFASLQLGVP RLLKDFDIEC ALPISDVEYK DQLSMENEKA 300
  301 DKKAKKIQLQ GQVSSFSLQI IRFAKILGNI LDSIFKRGMM DERITSEVAL VHENALDNWR 360
  361 NQLPEMYYFQ ITVNGTVNLD EIRATNQRNT ETKFDKKDII LFEKKILLLF YFLAKSMIHL 420
  421 PVIATKPLPK NVDNATKKKQ SMFNNDSKGA TNQDHMILDV DMTSPAIRTS SSYIILQQAT 480
  481 NATLTIFQAI NSMYLPLPLN VSRTLIRFSL LCARGSLEYT K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 4.03985756894684 bayes_pls_golite062009
nucleic acid binding 3.97978190843512 bayes_pls_golite062009
transcription factor activity 2.87348461329489 bayes_pls_golite062009
binding 2.82809978070212 bayes_pls_golite062009
sequence-specific DNA binding 2.77469997789536 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.70904317608141 bayes_pls_golite062009
transcription activator activity 2.1512787242583 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.08956709478484 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [854-1433] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGALFLDNKN LLLDTIKDIE NDRLLDLPGI ASWHTLKLFD MSINLLLKAP NVKVERLDKF  60
   61 LEKKLNYYNR LMGLPPATTT SLKPLFGSQS KNSLENRQRT PNVKRENPEH EYLYGNDSNN 120
  121 NNNSEAGHSP MTNTTNGNKR LKYEKDAKRN AKDGGISKGE NAHNFQNDTK KNMSTSNLFP 180
  181 FSFSNTDLTA LFTHPEGPNC TNTNNGNVDV CNRASTDATD ANIENLSFLN MAPFLQTGNS 240
  241 NIGQNTIENK PMHMDAIFSL PSNLDLMKDN MDSKPEQLEP VIKQNPENSK NNQFHQKGKS 300
  301 TNMEKNNLSF NNKSNYSLTK LMRLLNNDNS FSNISINNFL YQNDQNSASA DPGTNKKAVT 360
  361 NAGANFKPPS TGSNTSQGSI LGSTKHGMDN CDFNDLGNFN NFMTNVNYSG VDYDYIVDAS 420
  421 LGLAPLLVDT PDISNTNTTS TTSNRSKNSI ILDTTFNDDL DRSRMNAREV LNPTDSILSQ 480
  481 GMVSSVSTRN TSNQRSLSSG NDSKGDSSSQ ENSKSATGNQ LDTPSTLFQM RRTSSGPSAS 540
  541 HRGPRRPQKN RYNTDRSKSS GGGSSNTDNV SDLFQWQNAK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [513-764] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMSTTSLPSL QLLSLASFYY LNVGDISAIY GVRGRIVSMA QQLRLHRCPS AVLSVHSNPV  60
   61 LQKFEQSERR LLFWAIYYVD VFASLQLGVP RLLKDFDIEC ALPISDVEYK DQLSMENEKA 120
  121 DKKAKKIQLQ GQVSSFSLQI IRFAKILGNI LDSIFKRGMM DERITSEVAL VHENALDNWR 180
  181 NQLPEMYYFQ ITVNGTVNLD EIRATNQRNT ETKFDKKDII LFEKKILLLF YFLAKSMIHL 240
  241 PVIATKPLPK NV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [765-824] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNATKKKQSM FNNDSKGATN QDHMILDVDM TSPAIRTSSS YIILQQATNA TLTIFQAINS  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [825-1044] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLPLPLNVS RTLIRFSLLC ARGSLEYTKG GALFLDNKNL LLDTIKDIEN DRLLDLPGIA  60
   61 SWHTLKLFDM SINLLLKAPN VKVERLDKFL EKKLNYYNRL MGLPPATTTS LKPLFGSQSK 120
  121 NSLENRQRTP NVKRENPEHE YLYGNDSNNN NNSEAGHSPM TNTTNGNKRL KYEKDAKRNA 180
  181 KDGGISKGEN AHNFQNDTKK NMSTSNLFPF SFSNTDLTAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1045-1206] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTHPEGPNCT NTNNGNVDVC NRASTDATDA NIENLSFLNM APFLQTGNSN IGQNTIENKP  60
   61 MHMDAIFSLP SNLDLMKDNM DSKPEQLEPV IKQNPENSKN NQFHQKGKST NMEKNNLSFN 120
  121 NKSNYSLTKL MRLLNNDNSF SNISINNFLY QNDQNSASAD PG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1207-1433] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNKKAVTNAG ANFKPPSTGS NTSQGSILGS TKHGMDNCDF NDLGNFNNFM TNVNYSGVDY  60
   61 DYIVDASLGL APLLVDTPDI SNTNTTSTTS NRSKNSIILD TTFNDDLDRS RMNAREVLNP 120
  121 TDSILSQGMV SSVSTRNTSN QRSLSSGNDS KGDSSSQENS KSATGNQLDT PSTLFQMRRT 180
  181 SSGPSASHRG PRRPQKNRYN TDRSKSSGGG SSNTDNVSDL FQWQNAK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle