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View Structure Prediction Details

Protein: RNH1
Organism: Saccharomyces cerevisiae
Length: 348 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNH1.

Description E-value Query
Range
Subject
Range
gi|17902094 - gi|17902094|gb|AAL47767.1| pol protein [Human immunodeficiency virus 1]
4.0E-94 [45..347] [450..712]

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Predicted Domain #1
Region A:
Residues: [1-47]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARQGNFYAV RKGRETGIYN TWNECKNQVD GYGGAIYKKF NSYEQAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 205.190949
Match: 1qhkA_
Description: N-terminal domain of RNase HI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 4.81599779544001 bayes_pls_golite062009
exoribonuclease activity 3.01417328311605 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 2.89077854960958 bayes_pls_golite062009
nuclease activity 2.65398446409354 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
3'-5'-exoribonuclease activity 2.49957333962564 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
exonuclease activity 1.4327316829508 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
nucleic acid binding 1.23371034593624 bayes_pls_golite062009
binding 1.20709976964365 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
DNA binding 0.860359347662869 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.389326716045122 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
protein binding 0.242714557118293 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [48-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFLGQPNTTS NYGSSTHAGG QVSKPHTTQK RVHRRNRPLH YSSLTSSSAC SSLSSANTNT  60
   61 FYSVKSNVPN IESKIFNNWK DCQAYVKHKR GITFKKFEDQ LAAENFISGM SAHDYKLMNI 120
  121 SKESFESK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.69897
Match: 1rt3A_
Description: HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [176-348]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKLSSNTMYN KSMNVYCDGS SFGNGTSSSR AGYGAYFEGA PEENISEPLL SGAQTNNRAE  60
   61 IEAVSEALKK IWEKLTNEKE KVNYQIKTDS EYVTKLLNDR YMTYDNKKLE GLPNSDLIVP 120
  121 LVQRFVKVKK YYELNKECFK NNGKFQIEWV KGHDGDPGNE MADFLAKKGA SRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.69897
Match: 1rt3A_
Description: HIV RNase H (Domain of reverse transcriptase); HIV-1 reverse transcriptase
Matching Structure (courtesy of the PDB):

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