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View Structure Prediction Details

Protein: UBX4
Organism: Saccharomyces cerevisiae
Length: 416 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBX4.

Description E-value Query
Range
Subject
Range
UBX4_YEAST - UBX domain-containing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBX4 PE=...
UBX4 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.0 [1..416] [1..416]
ASPSCR1 - alveolar soft part sarcoma chromosome region, candidate 1
3.0E-44 [152..413] [250..548]
ASPC1_MOUSE - Tether containing UBX domain for GLUT4 OS=Mus musculus GN=Aspscr1 PE=1 SV=1
2.0E-42 [130..413] [249..545]
PUX10_ARATH - Plant UBX domain-containing protein 10 OS=Arabidopsis thaliana GN=PUX10 PE=2 SV=1
1.0E-35 [126..353] [246..480]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-35 [126..353] [232..466]

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Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMVTVKYNF QLFKCKVSLN STLNDVLHQS IQFFQLHTSS NDWSLIHLDK PVPLDLPWRL  60
   61 LNLPTGVNLE LSKSSNFPVA NKTNREDIPF NTIKIRFQIP GRDSVVKEMP SDQPIAPILR 120
  121 QMSGAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.296 d.26.1 FKBP-like
View Download 0.295 c.55.3 Ribonuclease H-like
View Download 0.397 d.110.4 SNARE-like
View Download 0.345 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.286 a.95.1 Influenza virus matrix protein M1
View Download 0.286 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.282 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.269 c.114.1 YchN-like
View Download 0.249 d.15.1 Ubiquitin-like
View Download 0.206 d.15.2 CAD & PB1 domains
View Download 0.206 c.47.1 Thioredoxin-like
View Download 0.204 d.94.1 HPr-like
View Download 0.203 b.80.3 Cell-division inhibitor MinC, C-terminal domain

Predicted functions:

Term Confidence Notes
binding 2.11588141989606 bayes_pls_golite062009
protein binding 1.75262085947538 bayes_pls_golite062009
small conjugating protein ligase activity 1.64626529520014 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.03640529353043 bayes_pls_golite062009
acid-amino acid ligase activity 0.778769490362734 bayes_pls_golite062009
nucleic acid binding 0.406724367405638 bayes_pls_golite062009
hydrolase activity 0.266557627363523 bayes_pls_golite062009
DNA binding 0.102021710653816 bayes_pls_golite062009
transcription regulator activity 0.0672274772804511 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [127-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDDFKIQVFS KIIEFKTIKD ENLTLENLGI QEPSSVRLIF NNTSHSEGIS ANSAIHPKQT  60
   61 PPTMTNPETV ASLPPHELHK PSVFLPSDEP LAVIKDQIE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.293 0.000 nucleus d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.380 0.000 nucleus b.114.1 N-utilization substance G protein NusG, insert domain

Predicted Domain #3
Region A:
Residues: [226-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEDYELTVE QAKKYQKMLS SKAGTLGGPI LTKRLREQSA NNLPKKNKAI SECLLRVKFP  60
   61 DRSHIQIAFK PNEDMRTVYN VVSQFLIDEN MPFTLNQSHP FKPLAKDDKK LLDDLEFGSK 120
  121 TMLLFETNSN SNGPLIKAHL LEDAQKITHE TRTTPSVNTI NKSNPQGPSD NATSIKKTLN 180
  181 RVPKWMKLSK K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1jruA_
Description: p47
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.19381585790185 bayes_pls_golite062009
protein binding 1.89134588490127 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
nucleic acid binding 0.383121378043805 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009
DNA binding 0.0840213088061073 bayes_pls_golite062009
transcription regulator activity 0.0485636215870291 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle