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View Structure Prediction Details

Protein: YMR031C
Organism: Saccharomyces cerevisiae
Length: 843 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR031C.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
0.0 [3..838] [997..1799]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
0.0 [3..838] [998..1800]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..838] [14..816]
gi|45383668, gi|... - gi|9800486|gb|AAF99314.1|AF272033_1 fast myosin heavy chain isoform 2 [Gallus gallus], gi|45383668|r...
0.0 [3..838] [1003..1805]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
0.0 [3..838] [999..1801]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
0.0 [3..838] [1000..1802]

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Predicted Domain #1
Region A:
Residues: [1-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLISAVEDR DIHNIGKTSG GGSRTSSITS SKKSLKHGSK SLRKPKVYQT TGEPLSREAL  60
   61 YKAKLKYGVY QSPAQSYSIG VSDAHAASDK AANLAHDNQT TVEAYKRMFI DPNATKAASK 120
  121 MGPKVVRNNS ITSATSKTSK ESQTKRKSKE SPGAAASKAY SMTMETTSLS SQTNSRSYSI 180
  181 TSASSVLSGA SGSFNSTVNP KPKTLNLEKV LVGAEKKAES RIKERWEPEK TNFQYGVKTD 240
  241 EHGNLNQFSF SNEMMNNIMA KVDAPKAQDL QKVKKVSAEK EAKSMKFALG AANAVKDMHP 300
  301 GEDIDKSIAL KAQKRETYLS QLTSQQVLTL ARANVDRQLD IIEKSDMHRK LFTNMEYNKA 360
  361 AVAVAQSNHQ KKTEFHNKIN M

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [382-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGLFLSPED ITKIASGLIS PVLGEVSERA EAQRAMDEEI AERTEAYNKS SNEWETMERS  60
   61 IISN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.807 0.196 cytoplasm a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.794 0.196 cytoplasm a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.759 0.196 cytoplasm a.30.1 ROP protein
View Download 0.654 0.196 cytoplasm a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.707 0.196 cytoplasm a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.599 0.196 cytoplasm a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.528 0.196 cytoplasm f.13.1 Family A G protein-coupled receptor-like
View Download 0.512 0.196 cytoplasm a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.504 0.196 cytoplasm a.2.2 Ribosomal protein L29 (L29p)
View Download 0.498 0.196 cytoplasm a.64.1 Saposin
View Download 0.494 0.196 cytoplasm a.2.7 tRNA-binding arm
View Download 0.492 0.196 cytoplasm a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.472 0.196 cytoplasm a.2.7 tRNA-binding arm
View Download 0.467 0.196 cytoplasm a.4.5 "Winged helix" DNA-binding domain
View Download 0.449 0.196 cytoplasm a.112.1 Description not found.
View Download 0.441 0.196 cytoplasm a.7.5 Tubulin chaperone cofactor A
View Download 0.394 0.196 cytoplasm a.65.1 Annexin
View Download 0.378 0.196 cytoplasm a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.368 0.196 cytoplasm a.16.1 S15/NS1 RNA-binding domain
View Download 0.364 0.196 cytoplasm a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.344 0.196 cytoplasm a.126.1 Serum albumin-like
View Download 0.342 0.196 cytoplasm g.2.2 Neurotoxin B-IV
View Download 0.337 0.196 cytoplasm a.5.2 UBA-like
View Download 0.336 0.196 cytoplasm a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.333 0.196 cytoplasm a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.310 0.196 cytoplasm a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.307 0.196 cytoplasm a.16.1 S15/NS1 RNA-binding domain
View Download 0.306 0.196 cytoplasm a.23.5 Hemolysin expression modulating protein HHA
View Download 0.305 0.196 cytoplasm a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.290 0.196 cytoplasm a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.281 0.196 cytoplasm a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.276 0.196 cytoplasm a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.250 0.196 cytoplasm a.7.8 GAT domain
View Download 0.247 0.196 cytoplasm a.64.1 Saposin
View Download 0.247 0.196 cytoplasm a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.238 0.196 cytoplasm a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.238 0.196 cytoplasm a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.229 0.196 cytoplasm a.4.1 Homeodomain-like
View Download 0.226 0.196 cytoplasm a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.224 0.196 cytoplasm a.7.6 Ribosomal protein S20
View Download 0.224 0.196 cytoplasm a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.220 0.196 cytoplasm a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.215 0.196 cytoplasm a.4.1 Homeodomain-like
View Download 0.211 0.196 cytoplasm a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.211 0.196 cytoplasm a.2.3 Chaperone J-domain
View Download 0.210 0.196 cytoplasm a.24.9 alpha-catenin/vinculin
View Download 0.209 0.196 cytoplasm a.5.6 Hypothetical protein MTH1615
View Download 0.207 0.196 cytoplasm a.6.1 Putative DNA-binding domain
View Download 0.206 0.196 cytoplasm a.4.12 TrpR-like
View Download 0.203 0.196 cytoplasm a.3.1 Cytochrome c
View Download 0.202 0.196 cytoplasm f.17.1 F1F0 ATP synthase subunit C
View Download 0.201 0.196 cytoplasm e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment

Predicted functions:

Term Confidence Notes
binding 1.21996214365885 bayes_pls_golite062009
transcription regulator activity 1.17665418880398 bayes_pls_golite062009
DNA binding 1.07598753330232 bayes_pls_golite062009
nucleic acid binding 1.03922880212908 bayes_pls_golite062009
transcription factor activity 0.497219747270883 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [446-843]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAKVLTTTAN RHQTEKKTSQ EKIKASFDAL VARMDTKVAE RETLLEDTKS KEIEFKKQMQ  60
   61 QELKDEKARL DQDLEEWGKK CEQDITEARK EQEELLKPYH DDLANAEAEH KTLVEERDEI 120
  121 NAEISRLQDA IVDHKRKISG YGNDLDAQKN RNIREDDKLL ELGQTKESLE SHLNDDVIIL 180
  181 ANKAKEQAEL STKEARLKQL EVDSLINERK SELNATEIEL KKEKLNLLEA MKDVASARGD 240
  241 DKIDEEKVKK LIGMTSEEYL TQNKSVEKNV EDLPTQLEKI EEGDELKKEE IVGAETKNSG 300
  301 GDGVPVSTAA KEATETSSAV QTKEPEEKIS IGNKSSGKED ANDCKSAEHS KEISVSQKAG 360
  361 NNKSLGVSPD SLEHTFSGFS QGSSIEDDQD AISNQEKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.616428
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [517-843]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDLEEWGKKC EQDITEARKE QEELLKPYHD DLANAEAEHK TLVEERDEIN AEISRLQDAI  60
   61 VDHKRKISGY GNDLDAQKNR NIREDDKLLE LGQTKESLES HLNDDVIILA NKAKEQAELS 120
  121 TKEARLKQLE VDSLINERKS ELNATEIELK KEKLNLLEAM KDVASARGDD KIDEEKVKKL 180
  181 IGMTSEEYLT QNKSVEKNVE DLPTQLEKIE EGDELKKEEI VGAETKNSGG DGVPVSTAAK 240
  241 EATETSSAVQ TKEPEEKISI GNKSSGKEDA NDCKSAEHSK EISVSQKAGN NKSLGVSPDS 300
  301 LEHTFSGFSQ GSSIEDDQDA ISNQEKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle