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View Structure Prediction Details

Protein: PEX12
Organism: Saccharomyces cerevisiae
Length: 399 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX12.

Description E-value Query
Range		 Subject
Range
PEX12_YEAST - Peroxisome assembly protein 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX12 PE=...
gi|207342418 - gi|207342418|gb|EDZ70191.1| YMR026Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190408265 - gi|190408265|gb|EDV11530.1| C3HC4 zinc-binding integral peroxisomal membrane protein [Saccharomyces ...
PEX12 - C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisom...
 1.0E-94 [1..399] [1..399]
PEX12_PICPA - Peroxisome assembly protein 12 OS=Komagataella pastoris GN=PEX12 PE=3 SV=1
 2.0E-74 [1..399] [1..409]
PEX12 - peroxisomal biogenesis factor 12
gi|123994893 - gi|123994893|gb|ABM85048.1| peroxisomal biogenesis factor 12 [synthetic construct]
 3.0E-74 [31..384] [17..354]
PEX12_CRILO - Peroxisome assembly protein 12 OS=Cricetulus longicaudatus GN=PEX12 PE=2 SV=1
tr|G3I8C0|G3I8C0... - Peroxisome assembly protein 12 OS=Cricetulus griseus GN=I79_019783 PE=3 SV=1
 2.0E-73 [31..384] [17..354]
PEX12_MOUSE - Peroxisome assembly protein 12 OS=Mus musculus GN=Pex12 PE=1 SV=1
 1.0E-71 [31..384] [17..354]
PEX12_RAT - Peroxisome assembly protein 12 OS=Rattus norvegicus GN=Pex12 PE=2 SV=1
 5.0E-71 [31..384] [17..354]
prx-12 - Zinc finger, C3HC4 type (RING finger) status:Partially_confirmed UniProt:Q19189 protein_id:CAA92113....
 6.0E-62 [15..372] [6..345]
CHR28_ARATH - Helicase-like transcription factor CHR28 OS=Arabidopsis thaliana GN=CHR28 PE=1 SV=1
 7.0E-50 [107..392] [473..740]

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Predicted Domain #1
Region A:
Residues: [1-65] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS IRYLLANHLV  60
   61 ANFPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [66-151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYTLRLNKYF FEWFQAIKGF VEWYHLKTYN STFIDRFYGL QLFSSRDRNL ALTQCLNPKG  60
   61 QSEWPQGLQL NQQQKSVIFL EKIILP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [165-184] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMNNIFSSDE TENKWPKRAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.55003340159545 bayes_pls_golite062009
protein binding 2.35325421236395 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.20438586677555 bayes_pls_golite062009
small conjugating protein ligase activity 1.97264874084155 bayes_pls_golite062009
signal transducer activity 1.5438780730211 bayes_pls_golite062009
molecular transducer activity 1.5438780730211 bayes_pls_golite062009
acid-amino acid ligase activity 1.26357595913158 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
cytoskeletal protein binding 0.75057755360417 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
molecular adaptor activity 0.68555837423221 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.293268642733772 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
protein binding, bridging 0.230308623372106 bayes_pls_golite062009
kinase activity 0.193243470329802 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
protein kinase activity 0.0865488336042732 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009
receptor binding 0.00920732436841987 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [152-164] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YITAKLDEIL EKI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [185-333] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRIYPFIKKL LALSNLLVKL LFLTKRTGSV SLLQYLFKIE YTTVRPLSSE LSGLKETKGM  60
   61 DNRLRKTNIS SIFALMQGQL SIIPRFLTFM GSQFFPTFIF VLRVYQWWTT QDMTTKLQKR 120
  121 VNDLDEDIPR PPFSSHSDKT EDKEGVSEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [334-399] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPVCEKTVQN PCVLETGYVA CYPCAISYLV NNEGHCPVTN KKLLGCTYNK HTNKWEVVTG  60
   61 IRKLLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle