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View Structure Prediction Details

Protein: PEX12
Organism: Saccharomyces cerevisiae
Length: 399 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX12.

Description E-value Query
Range		 Subject
Range
PEX12_YEAST - Peroxisome assembly protein 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX12 PE=...
gi|207342418 - gi|207342418|gb|EDZ70191.1| YMR026Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190408265 - gi|190408265|gb|EDV11530.1| C3HC4 zinc-binding integral peroxisomal membrane protein [Saccharomyces ...
PEX12 - C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisom...
 1.0E-94 [1..399] [1..399]
PEX12_PICPA - Peroxisome assembly protein 12 OS=Komagataella pastoris GN=PEX12 PE=3 SV=1
 2.0E-74 [1..399] [1..409]
PEX12 - peroxisomal biogenesis factor 12
gi|123994893 - gi|123994893|gb|ABM85048.1| peroxisomal biogenesis factor 12 [synthetic construct]
 3.0E-74 [31..384] [17..354]
PEX12_CRILO - Peroxisome assembly protein 12 OS=Cricetulus longicaudatus GN=PEX12 PE=2 SV=1
tr|G3I8C0|G3I8C0... - Peroxisome assembly protein 12 OS=Cricetulus griseus GN=I79_019783 PE=3 SV=1
 2.0E-73 [31..384] [17..354]
PEX12_MOUSE - Peroxisome assembly protein 12 OS=Mus musculus GN=Pex12 PE=1 SV=1
 1.0E-71 [31..384] [17..354]
PEX12_RAT - Peroxisome assembly protein 12 OS=Rattus norvegicus GN=Pex12 PE=2 SV=1
 5.0E-71 [31..384] [17..354]
prx-12 - Zinc finger, C3HC4 type (RING finger) status:Partially_confirmed UniProt:Q19189 protein_id:CAA92113....
 6.0E-62 [15..372] [6..345]
CHR28_ARATH - Helicase-like transcription factor CHR28 OS=Arabidopsis thaliana GN=CHR28 PE=1 SV=1
 7.0E-50 [107..392] [473..740]

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Predicted Domain #1
Region A:
Residues: [1-65] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS IRYLLANHLV  60
   61 ANFPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.612 a.3.1 Cytochrome c
View Download 0.384 a.4.1 Homeodomain-like
View Download 0.497 a.60.8 HRDC-like
View Download 0.410 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.408 a.46.1 Methionine synthase domain
View Download 0.362 a.4.1 Homeodomain-like
View Download 0.331 a.4.5 "Winged helix" DNA-binding domain
View Download 0.286 a.4.7 Ribosomal protein L11, C-terminal domain
View Download 0.278 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.261 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.259 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.257 a.74.1 Cyclin-like
View Download 0.254 a.112.1 Description not found.
View Download 0.254 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.247 a.39.1 EF-hand
View Download 0.240 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.236 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.232 a.3.1 Cytochrome c
View Download 0.231 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.228 a.7.7 BAG domain
View Download 0.223 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.222 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.215 a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.209 a.30.1 ROP protein
View Download 0.208 a.8.1 Bacterial immunoglobulin/albumin-binding domains

Predicted Domain #2
Region A:
Residues: [66-151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYTLRLNKYF FEWFQAIKGF VEWYHLKTYN STFIDRFYGL QLFSSRDRNL ALTQCLNPKG  60
   61 QSEWPQGLQL NQQQKSVIFL EKIILP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [165-184] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMNNIFSSDE TENKWPKRAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.55003340159545 bayes_pls_golite062009
protein binding 2.35325421236395 bayes_pls_golite062009
ubiquitin-protein ligase activity 2.20438586677555 bayes_pls_golite062009
small conjugating protein ligase activity 1.97264874084155 bayes_pls_golite062009
signal transducer activity 1.5438780730211 bayes_pls_golite062009
molecular transducer activity 1.5438780730211 bayes_pls_golite062009
acid-amino acid ligase activity 1.26357595913158 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
cytoskeletal protein binding 0.75057755360417 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
molecular adaptor activity 0.68555837423221 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.293268642733772 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
protein binding, bridging 0.230308623372106 bayes_pls_golite062009
kinase activity 0.193243470329802 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
protein kinase activity 0.0865488336042732 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009
receptor binding 0.00920732436841987 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [152-164] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YITAKLDEIL EKI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [185-333] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRIYPFIKKL LALSNLLVKL LFLTKRTGSV SLLQYLFKIE YTTVRPLSSE LSGLKETKGM  60
   61 DNRLRKTNIS SIFALMQGQL SIIPRFLTFM GSQFFPTFIF VLRVYQWWTT QDMTTKLQKR 120
  121 VNDLDEDIPR PPFSSHSDKT EDKEGVSEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [334-399] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPVCEKTVQN PCVLETGYVA CYPCAISYLV NNEGHCPVTN KKLLGCTYNK HTNKWEVVTG  60
   61 IRKLLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.221849
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle