YRC Public Data Repository - Protein Structure Prediction

Protein:	PPZ1
Organism:	Saccharomyces cerevisiae
Length:	692 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPZ1.

Description	E-value	Query Range	Subject Range
PPZ1 - Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transp... PPZ1_YEAST - Serine/threonine-protein phosphatase PP-Z1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...	0.0	[1..692]	[1..692]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[357..686]	[3..332]
PP1A_MOUSE - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Mus musculus GN=Ppp1ca PE=1 SV=1 tr\|G3MX90\|G3MX90... - Serine/threonine-protein phosphatase OS=Bos taurus PE=3 SV=1 gi\|54035381 - gb\|AAH84049.1\| Unknown (protein for MGC:98412) [Xenopus laevis]	0.0	[355..681]	[1..329]
PP1G_RAT - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Rattus norvegicus GN=Ppp1cc PE=1... gi\|55250791 - gb\|AAH86013.1\| Unknown (protein for MGC:98061) [Xenopus laevis] PP1G_BOVIN - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Bos taurus GN=PPP1CC PE=2 SV=1 PP1G_MOUSE - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Mus musculus GN=Ppp1cc PE=1 SV=1 gi\|87621736, gi\|... - gi\|87621736\|gb\|ABD38709.1\| protein phosphatase 1 catalytic subunit gamma isoform [Sus scrofa], gi\|11...	0.0	[357..677]	[3..316]
gi\|999339 - gi\|999339\|gb\|AAB34333.1\| protein phosphatase 1 alpha; PP1 alpha [Rattus sp.] PP1A_RABIT - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Oryctolagus cuniculus GN=PPP1CA ... PPP1CA - protein phosphatase 1, catalytic subunit, alpha isozyme ENSMMUG000000172... - null, null PP1A_BOVIN - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Bos taurus GN=PPP1CA PE=2 SV=1 IPI:IPI00323370.... - Ensembl_locations(Chr-bp):None Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit PP1A_RAT - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Rattus norvegicus GN=Ppp1ca PE=1... gi\|60656413 - gi\|60656413\|gb\|AAX32770.1\| protein phosphatase 1 catalytic subunit alpha isoform [synthetic construc... HGNC:9281\|MIM:17... - phosphatase 1, catalytic subunit, alpha isozyme gi\|87621715, gi\|... - gi\|87621715\|gb\|ABD38708.1\| protein phosphatase 1 catalytic subunit alpha isoform [Sus scrofa], gi\|11...	0.0	[355..681]	[1..329]

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Predicted Domain #1

Region A:
Residues: [1-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNSSSKSSK KDSHSNSSSR NPRPQVSRTE TSHSVKSAKS NKSSRSRRSL PSSSTTNTNS  60
   61 NVPDPSTPSK PNLEVNHQRH SSHTNRYHFP SSSHSHSNSQ NELLTTPSSS STKRPSTSRR 120
  121 SSYNTKAAAD LPPSMIQMEP KSPILKTNNS STHVSKHKSS YSSTYYENAL TDDDNDDKDN 180
  181 DISHTKRFSR SSNSRPSSIR SGSVSRRKSD VTHEEPNNGS YSSNNQENYL VQALTRSNSH 240
  241 ASSLHSRKSS FGSDGNTAYS TPLNSPGLSK LTDHSGEYFT SNSTSSLNHH SSRDIYPSKH 300
  301 ISNDDDIENS SQLSNIHASM ENVNDKNNNI TDSKKDPNEE FNDIMQSSGN KNAP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.84
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [355-692]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKFKKPIDID ETIQKLLDAG YAAKRTKNVC LKNNEILQIC IKAREIFLSQ PSLLELSPPV  60
   61 KIVGDVHGQY GDLLRLFTKC GFPPSSNYLF LGDYVDRGKQ SLETILLLFC YKIKYPENFF 120
  121 LLRGNHECAN VTRVYGFYDE CKRRCNIKIW KTFIDTFNTL PLAAIVAGKI FCVHGGLSPV 180
  181 LNSMDEIRHV VRPTDVPDFG LINDLLWSDP TDSPNEWEDN ERGVSYCYNK VAINKFLNKF 240
  241 GFDLVCRAHM VVEDGYEFFN DRSLVTVFSA PNYCGEFDNW GAVMSVSEGL LCSFELLDPL 300
  301 DSAALKQVMK KGRQERKLAN QQQQMMETSI TNDNESQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1409.0
Match:	1it6A_
Description:	Protein phosphatase-1 (PP-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [354-692]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKKFKKPIDI DETIQKLLDA GYAAKRTKNV CLKNNEILQI CIKAREIFLS QPSLLELSPP  60
   61 VKIVGDVHGQ YGDLLRLFTK CGFPPSSNYL FLGDYVDRGK QSLETILLLF CYKIKYPENF 120
  121 FLLRGNHECA NVTRVYGFYD ECKRRCNIKI WKTFIDTFNT LPLAAIVAGK IFCVHGGLSP 180
  181 VLNSMDEIRH VVRPTDVPDF GLINDLLWSD PTDSPNEWED NERGVSYCYN KVAINKFLNK 240
  241 FGFDLVCRAH MVVEDGYEFF NDRSLVTVFS APNYCGEFDN WGAVMSVSEG LLCSFELLDP 300
  301 LDSAALKQVM KKGRQERKLA NQQQQMMETS ITNDNESQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	161.0
Match:	2o8aA
Description:	No description for 2o8aA was found.

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
substrate-specific transporter activity	0.783004917746429	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: