| Protein: | APC2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 853 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APC2.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [1..853] | [1..853] |
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0.0 | [34..838] | [17..773] |
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0.0 | [34..838] | [17..773] |
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0.0 | [32..839] | [18..767] |
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0.0 | [33..832] | [10..742] |
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0.0 | [62..832] | [55..771] |
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0.0 | [33..838] | [15..771] |
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0.0 | [34..838] | [15..767] |
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Region A: Residues: [1-93] |
1 11 21 31 41 51
| | | | | |
1 MSFQITPTRD LKVITDELQT LSSYIFHTNI VDDLNSLLTW MSPNDAKSNH QLRPPSLRIK 60
61 NIIKVLFPNN ATTSPYSMIN TSQANNSIVN EGN
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| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.474 | 0.967 | mitotic spindle elongation | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.340 | 0.967 | mitotic spindle elongation | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.266 | 0.967 | mitotic spindle elongation | a.141.1 | Frizzled cystein-rich domain |
| View | Download | 0.337 | 0.967 | mitotic spindle elongation | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.285 | 0.967 | mitotic spindle elongation | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.242 | 0.967 | mitotic spindle elongation | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.242 | 0.967 | mitotic spindle elongation | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.233 | 0.967 | mitotic spindle elongation | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.232 | 0.967 | mitotic spindle elongation | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.231 | 0.967 | mitotic spindle elongation | d.17.2 | Copper amine oxidase, domains 1 and 2 |
| View | Download | 0.211 | 0.967 | mitotic spindle elongation | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.201 | 0.967 | mitotic spindle elongation | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
| Term | Confidence | Notes |
| ubiquitin-protein ligase activity | 9.47178230940453 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 9.15192834197166 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 8.12051073361876 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 6.87003086224111 | bayes_pls_golite062009 |
| ligase activity | 4.85660414833673 | bayes_pls_golite062009 |
| transcription regulator activity | 4.44907471960058 | bayes_pls_golite062009 |
| transcription factor activity | 3.48782936574155 | bayes_pls_golite062009 |
| transcription repressor activity | 2.39237599101586 | bayes_pls_golite062009 |
| binding | 2.3219000606044 | bayes_pls_golite062009 |
| transcription activator activity | 1.79615705315806 | bayes_pls_golite062009 |
| nucleic acid binding | 1.31024813110778 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.2152419300113 | bayes_pls_golite062009 |
| protein binding | 1.15192193279649 | bayes_pls_golite062009 |
| DNA binding | 1.05574145691051 | bayes_pls_golite062009 |
| vasopressin activated calcium mobilizing receptor activity | 0.416181464241621 | bayes_pls_golite062009 |
| transcription factor binding | 0.31161141447305 | bayes_pls_golite062009 |
| catalytic activity | 0.201606344181603 | bayes_pls_golite062009 |
| hydrolase activity | 0.140191206949582 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.0565989703351002 | bayes_pls_golite062009 |
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Region A: Residues: [94-186] |
1 11 21 31 41 51
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1 TNKELQLQLF STLKEFYIFQ VRYHFFLHFN NINYLKDIQR WENYYEFPLR YVPIFDVNVN 60
61 DWALELNSLR HYLLNRNIKF KNNLRTRLDK LIM
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.672 | 0.933 | mitotic spindle elongation | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.782 | 0.013 | mitotic spindle elongation | a.118.1 | ARM repeat |
| View | Download | 0.778 | 0.003 | mitotic spindle elongation | a.47.2 | t-snare proteins |
| View | Download | 0.754 | 0.000 | mitotic spindle elongation | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.705 | N/A | N/A | a.112.1 | Description not found. |
| View | Download | 0.616 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.615 | N/A | N/A | a.51.1 | Cytochrome c oxidase subunit h |
| View | Download | 0.597 | N/A | N/A | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.585 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.576 | N/A | N/A | g.53.1 | TAZ domain |
| View | Download | 0.564 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.562 | N/A | N/A | a.29.5 | alpha-ketoacid dehydrogenase kinase, N-terminal domain |
| View | Download | 0.555 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.555 | N/A | N/A | d.58.43 | Mechanosensitive channel protein MscS (YggB), C-terminal domain |
| View | Download | 0.545 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.538 | N/A | N/A | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.538 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.521 | N/A | N/A | a.8.3 | Families 57/38 glycoside transferase middle domain |
| View | Download | 0.515 | N/A | N/A | d.58.49 | YajQ-like |
| View | Download | 0.492 | N/A | N/A | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.488 | N/A | N/A | a.78.1 | Fatty acid responsive transcription factor FadR, C-terminal domain |
| View | Download | 0.484 | N/A | N/A | d.52.4 | YhbC-like, N-terminal domain |
| View | Download | 0.473 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.466 | N/A | N/A | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.465 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.460 | N/A | N/A | a.7.5 | Tubulin chaperone cofactor A |
| View | Download | 0.449 | N/A | N/A | a.64.1 | Saposin |
| View | Download | 0.444 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.433 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.426 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.425 | N/A | N/A | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.422 | N/A | N/A | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.410 | N/A | N/A | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.410 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.409 | N/A | N/A | a.63.1 | Apolipophorin-III |
| View | Download | 0.400 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.398 | N/A | N/A | a.4.12 | TrpR-like |
| View | Download | 0.396 | N/A | N/A | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.376 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.371 | N/A | N/A | d.68.4 | YhbY-like |
| View | Download | 0.370 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.366 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.366 | N/A | N/A | c.9.1 | Barstar (barnase inhibitor) |
| View | Download | 0.348 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.346 | N/A | N/A | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.338 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.336 | N/A | N/A | i.11.1 | Computational models partly based on NMR data |
| View | Download | 0.333 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.330 | N/A | N/A | d.68.1 | Translation initiation factor IF3, C-terminal domain |
| View | Download | 0.329 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.323 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.322 | N/A | N/A | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.320 | N/A | N/A | a.24.12 | Outer surface protein C (OspC) |
| View | Download | 0.319 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.317 | N/A | N/A | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.312 | N/A | N/A | b.40.2 | Bacterial enterotoxins |
| View | Download | 0.309 | N/A | N/A | a.91.1 | Regulator of G-protein signalling, RGS |
| View | Download | 0.304 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.302 | N/A | N/A | d.130.1 | S-adenosylmethionine synthetase |
| View | Download | 0.301 | N/A | N/A | a.30.2 | Homodimeric domain of signal transducing histidine kinase |
| View | Download | 0.300 | N/A | N/A | d.39.1 | Dynein light chain 8 (DLC8) |
| View | Download | 0.293 | N/A | N/A | a.8.3 | Families 57/38 glycoside transferase middle domain |
| View | Download | 0.290 | N/A | N/A | c.55.7 | Methylated DNA-protein cysteine methyltransferase domain |
| View | Download | 0.290 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.289 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.283 | N/A | N/A | c.55.7 | Methylated DNA-protein cysteine methyltransferase domain |
| View | Download | 0.279 | N/A | N/A | a.66.1 | Transducin (alpha subunit), insertion domain |
| View | Download | 0.274 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.271 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.271 | N/A | N/A | a.30.1 | ROP protein |
| View | Download | 0.270 | N/A | N/A | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.268 | N/A | N/A | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.266 | N/A | N/A | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.260 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.260 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.256 | N/A | N/A | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.252 | N/A | N/A | c.49.1 | Pyruvate kinase, C-terminal domain |
| View | Download | 0.251 | N/A | N/A | d.57.1 | DNA damage-inducible protein DinI |
| View | Download | 0.249 | N/A | N/A | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.243 | N/A | N/A | a.185.1 | Gametocyte protein Pfg27 |
| View | Download | 0.243 | N/A | N/A | b.84.2 | Rudiment single hybrid motif |
| View | Download | 0.243 | N/A | N/A | a.7.2 | Enzyme IIa from lactose specific PTS, IIa-lac |
| View | Download | 0.241 | N/A | N/A | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.239 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.237 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.237 | N/A | N/A | d.87.1 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain |
| View | Download | 0.232 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.232 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.232 | N/A | N/A | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.229 | N/A | N/A | d.17.2 | Copper amine oxidase, domains 1 and 2 |
| View | Download | 0.223 | N/A | N/A | a.19.1 | Fertilization protein |
| View | Download | 0.223 | N/A | N/A | a.177.1 | Sigma2 domain of RNA polymerase sigma factors |
| View | Download | 0.220 | N/A | N/A | e.37.1 | Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains |
| View | Download | 0.219 | N/A | N/A | a.40.1 | Calponin-homology domain, CH-domain |
| View | Download | 0.219 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.218 | N/A | N/A | g.36.1 | Ferredoxin thioredoxin reductase (FTR), catalytic beta chain |
| View | Download | 0.214 | N/A | N/A | d.13.1 | HIT-like |
| View | Download | 0.214 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.211 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.209 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.208 | N/A | N/A | d.189.1 | PX domain |
| View | Download | 0.206 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.206 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.201 | N/A | N/A | a.4.1 | Homeodomain-like |
| View | Download | 0.201 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.200 | N/A | N/A | a.26.1 | 4-helical cytokines |
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Region A: Residues: [187-406] |
1 11 21 31 41 51
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1 DDDFDLADNL IQWLKSANGS LSSTELIVNA LYSKINKFCE DNMSRVWNKR FMIMETFNKF 60
61 INQYWSQFSK LVGCPEDDHE LTTTVFNCFE SNFLRIRTNE IFDICVLAYP DSKVTLLELR 120
121 KIMKDFKDYT NIVTTFLSDF KKYILNPSVT TVDALLRYVK TIKAFLVLDP TGRCLHSITT 180
181 FVKPYFQERK HLVNVLLYAM LDLPEEELKE KINFNVDMKA
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
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Region A: Residues: [407-758] |
1 11 21 31 41 51
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1 LLSLVDTLHD SDINQDTNIT KRDKNKKSPF LWNLKVKGKR ELNKDLPIRH AMLYEHILNY 60
61 YIAWVPEPND MIPGNIKSSY IKTNLFEVLL DLFESREFFI SEFRNLLTDR LFTLKFYTLD 120
121 EKWTRCLKLI REKIVKFTET SHSNYITNGI LGLLETTAPA ADADQSNLNS IDVMLWDIKC 180
181 SEELCRKMHE VAGLDPIIFP KFISLLYWKY NCDTQGSNDL AFHLPIDLER ELQKYSDIYS 240
241 QLKPGRKLQL CKDKGKVEIQ LAFKDGRKLV LDVSLEQCSV INQFDSPNDE PICLSLEQLS 300
301 ESLNIAPPRL THLLDFWIQK GVLLKENGTY SVIEHSEMDF DQAQKTAPME IE
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [759-853] |
1 11 21 31 41 51
| | | | | |
1 NSNYELHNDS EIERKYELTL QRSLPFIEGM LTNLGAMKLH KIHSFLKITV PKDWGYNRIT 60
61 LQQLEGYLNT LADEGRLKYI ANGSYEIVKN GHKNS
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| Detection Method: | |
| Confidence: | 375.64593 |
| Match: | 1lddA_ |
| Description: | Anaphase promoting complex (APC) |
Matching Structure (courtesy of the PDB): |
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