YRC Public Data Repository - Protein Structure Prediction

Protein:	FRS1
Organism:	Saccharomyces cerevisiae
Length:	595 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRS1.

Description	E-value	Query Range	Subject Range
FRS1 - Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate ac... SYFB_YEAST - Phenylalanine--tRNA ligase beta subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...	0.0	[1..595]	[1..595]
gi\|2792023 - gi\|2792023\|emb\|CAA73166.1\| phenylalanyl-tRNA synthetase [Candida albicans]	0.0	[1..595]	[1..593]
SYFB_SCHPO - Phenylalanine--tRNA ligase beta subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fr... SPAC23A1.12c - phenylalanine-tRNA ligase beta subunit	0.0	[1..595]	[1..589]
gi\|12848723 - gi\|12848723\|dbj\|BAB28064.1\| unnamed protein product [Mus musculus]	0.0	[1..595]	[1..589]
gi\|6841566 - gi\|6841566\|gb\|AAF29136.1\|AF161521_1 HSPC173 [Homo sapiens]	0.0	[1..595]	[1..589]
gi\|199602551, gi... - gi\|200390106\|ref\|ZP_03216717.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subs... SYFB_SALTY - Phenylalanine--tRNA ligase beta subunit OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7007... gi\|197262355, gi... - gi\|197262355\|ref\|ZP_03162429.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subs... lcl\|NC_016856.1_... - [gene=pheT] [protein=phenylalanyl-tRNA synthetase subunit beta] [protein_id=YP_005237200.1] [locatio... gi\|197247557, gi... - gi\|197247557\|ref\|YP_002146699.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica sub... gi\|238910846 - gi\|238910846\|ref\|ZP_04654683.1\| phenylalanyl-tRNA synthetase subunit beta [Salmonella enterica subsp... SYFB_SALTY - Phenylalanyl-tRNA synthetase beta chain OS=Salmonella typhimurium GN=pheT PE=3 SV=3 gi\|205332319, gi... - gi\|205332319\|gb\|EDZ19083.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subsp. e... gi\|205327737, gi... - gi\|205327737\|gb\|EDZ14501.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subsp. e... SYFB_SALTY - Phenylalanine--tRNA ligase beta chain OS=Salmonella typhimurium GN=pheT PE=3 SV=3 gi\|194469827, gi... - gi\|194469827\|ref\|ZP_03075811.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subs... gi\|194449577, gi... - gi\|194449577\|ref\|YP_002045345.1\| phenylalanyl-tRNA synthetase subunit beta [Salmonella enterica subs... gi\|168822197, gi... - gi\|205341293\|gb\|EDZ28057.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subsp. e... gi\|168240841, gi... - gi\|205339386\|gb\|EDZ26150.1\| phenylalanyl-tRNA synthetase, beta-subunit [Salmonella enterica subsp. e...	0.0	[3..594]	[104..689]

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Predicted Domain #1

Region A:
Residues: [1-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTVSVNKQQ LFDLLGKNYT SQEFDELCFE FGMEMDEDTT EEALKTGEEP ELKLDISANR  60
   61 YDLLCIEGIS QSLNEYLERK ERPDYKLSKP TTKLIIDKST EQIRPFATAA VLRNIKLNEK 120
  121 SYASFIALQD KLHANLCRNR SLVAMGTHDL DSIEGPFHYR ALPPKDIKFV PLNQTQEFTG 180
  181 DKLIEFYKSP EQKNNIGRYV HIIEDSPVFP VIMDSKDRVC SLPPLINSEH SKISVNTRNI 240
  241 LIDITATDKT KAEIVLNILT TMFSRYCDEP FTVEPVEIVS EHNGQSRLAP NFN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.9691
Match:	1b70B_
Description:	Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [294-375]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRIMDVSIKY INSCLGLDQS ADEIAHCLKK MSLHAVQSKE DKDILHVDIP VTRPDILHAC  60
   61 DIMEDAAVGY GFNNLPKGEK LS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.9691
Match:	1b70B_
Description:	Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phenylalanine-tRNA ligase activity	13.8919118344182	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	12.5698315343202	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	12.5698315343202	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	12.5592545638101	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
glycine-tRNA ligase activity	2.61548498770105	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
serine-tRNA ligase activity	2.07594942154162	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
transcription regulator activity	0.973820663472435	bayes_pls_golite062009
binding	0.951197041515827	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
nucleic acid binding	0.864670700044417	bayes_pls_golite062009
DNA binding	0.621789297870471	bayes_pls_golite062009
transcription factor activity	0.265631643816467	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [376-595]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NANFIAKPLP INKVSDIFRV ASSQATWVEV LPLTLCSHDE NFKFLRQSDN GDLAVKLANP  60
   61 KTLEYQVVRT TLLPGILKTV KENRKHSLPI KVFETGDVVF KDDKLERKAY NERHWAAIYV 120
  121 GKNSGFEIIQ GLLGKIMQTF RTEWIADYGA AASGRGYWIE EDDSVKTYFP GRGAKVMFRS 180
  181 KEGAEPKQIG HLGVLHPEVM MNFDVPFAAS FVEVNAEVFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.9691
Match:	1b70B_
Description:	Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: