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View Structure Prediction Details

Protein: BRE2
Organism: Saccharomyces cerevisiae
Length: 505 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRE2.

Description E-value Query
Range
Subject
Range
gi|190406056 - gi|190406056|gb|EDV09323.1| compass component [Saccharomyces cerevisiae RM11-1a]
BRE2 - Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing a...
BRE2_YEAST - COMPASS component BRE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRE2 PE=1 SV=2
0.0 [1..505] [1..505]
ash2 - Ash2-trithorax family protein
ASH2_SCHPO - Set1 complex component ash2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ash2 PE=3 SV=1
0.0 [46..499] [306..619]
ASH2L - ash2 (absent, small, or homeotic)-like (Drosophila)
gi|168277868 - gi|168277868|dbj|BAG10912.1| Set1/Ash2 histone methyltransferase complex subunit ASH2 [synthetic con...
4.0E-79 [17..294] [296..540]
ASH2L_MOUSE - Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Mus musculus GN=Ash2l PE=1 SV=1
8.0E-79 [17..294] [291..535]

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Predicted Domain #1
Region A:
Residues: [1-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE FVRTEDIPLN  60
   61 RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG LSISRDGNDL VSVPDQYGWR 120
  121 TARSDVCIKE GMTYWEVEVI RGGNKKFADG VNNKENADDS VDEVQSGIYE KMHKQVNDTP 180
  181 HLRFGVCRRE ASLEAPVGFD VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS 240
  241 LPSIHTQIKQ AKEFTKRRIF ALNSHMDTMN EPWRE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [276-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAENGPSRKK LKQETTNKEF QRALLEDIEY NDVVRDQIAI RYKNQLFFEA TDYVKTTKPE  60
   61 YYSSDKRERQ DYYQLEDSYL AIFQNGKYLG KAFENLKPLL PPFSELQYNE KFYLGYWQHG 120
  121 EARDESNDKN TTSAKKKKQQ QKKKKGLILR NKYVNNNKLG YYPTISCFNG GTARIISEED 180
  181 KLEYLDQIRS AYCVDGNSKV NTLDTLYKEQ IAEDIVWDII DELEQIALQQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.36160381896665 bayes_pls_golite062009
transcription regulator activity 2.17920418295591 bayes_pls_golite062009
nucleic acid binding 1.9830722589036 bayes_pls_golite062009
DNA binding 1.82525586215701 bayes_pls_golite062009
transcription repressor activity 1.26658862258675 bayes_pls_golite062009
transcription factor activity 1.16784442642933 bayes_pls_golite062009
protein binding 0.729859333703778 bayes_pls_golite062009
protein kinase activity 0.358328289529296 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.155087758481234 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.020584443202555 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [293-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEFQRALLED IEYNDVVRDQ IAIRYKNQLF FEATDYVKTT KPEYYSSDKR ERQDYYQLED  60
   61 SYLAIFQNGK YLGKAFENLK PLLPPFSELQ YNEKFYLGYW QHGEARDESN DKNTTSAKKK 120
  121 KQQQKKKKGL ILRNKYVNNN KLGYYPTISC FNGGTARIIS EEDKLEYLDQ IRSAYCVDGN 180
  181 SKVNTLDTLY KEQIAEDIVW DIIDELEQIA LQQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle