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View Structure Prediction Details

Protein: YLL032C
Organism: Saccharomyces cerevisiae
Length: 825 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLL032C.

Description E-value Query
Range
Subject
Range
YLL032C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; ...
YL032_YEAST - KH domain-containing protein YLL032C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YLL...
0.0 [1..825] [1..825]
VIGLN_MOUSE - Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1
1.0E-70 [88..785] [296..980]
VIGLN_RAT - Vigilin OS=Rattus norvegicus GN=Hdlbp PE=1 SV=1
1.0E-70 [88..748] [296..914]
gi|157928314, gi... - gi|168278465|dbj|BAG11112.1| vigilin [synthetic construct], gi|157928314|gb|ABW03453.1| high density...
HDLBP - high density lipoprotein binding protein
3.0E-70 [91..785] [255..980]
VIGLN_CHICK - Vigilin OS=Gallus gallus GN=HDLBP PE=2 SV=1
8.0E-66 [81..785] [244..981]
gi|4972720 - gi|4972720|gb|AAD34755.1| unknown [Drosophila melanogaster]
1.0E-65 [231..747] [14..524]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNFKIYSTV ITTAFLQVPH LYTTNRLWKP IEAPFLVEFL QKRISSKELK NTKAICHIDP  60
   61 SWVNLNASFI RDDMISIKAT TDDMDLDAIC RISLPLPMNT NDLTAELEKM KRILLDLSEK 120
  121 FNLELIITKE PAYFTPEQTG E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.546 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.711 d.109.1 Actin depolymerizing proteins
View Download 0.622 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.711 d.109.1 Actin depolymerizing proteins
View Download 0.625 d.109.1 Actin depolymerizing proteins
View Download 0.622 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.546 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.542 d.109.1 Actin depolymerizing proteins
View Download 0.523 d.109.1 Actin depolymerizing proteins
View Download 0.518 b.7.1 C2 domain (Calcium/lipid-binding domain, CaLB)
View Download 0.517 a.118.8 TPR-like
View Download 0.508 b.60.1 Lipocalins
View Download 0.502 d.42.1 POZ domain
View Download 0.502 d.58.9 RuBisCO, large subunit, small (N-terminal) domain
View Download 0.499 d.58.19 Bacterial exopeptidase dimerisation domain
View Download 0.478 d.109.1 Actin depolymerizing proteins
View Download 0.475 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.457 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.456 a.3.1 Cytochrome c
View Download 0.451 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.434 a.1.1 Globin-like
View Download 0.399 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.393 a.25.1 Ferritin-like
View Download 0.387 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.385 a.25.1 Ferritin-like
View Download 0.382 d.109.1 Actin depolymerizing proteins
View Download 0.371 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.370 d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.367 c.16.1 Lumazine synthase
View Download 0.365 d.3.1 Cysteine proteinases
View Download 0.363 a.1.1 Globin-like
View Download 0.357 a.1.1 Globin-like
View Download 0.348 c.16.1 Lumazine synthase
View Download 0.342 c.55.2 Creatinase/prolidase N-terminal domain
View Download 0.335 d.109.1 Actin depolymerizing proteins
View Download 0.333 c.50.1 Macro domain-like
View Download 0.327 a.118.8 TPR-like
View Download 0.310 a.118.9 ENTH/VHS domain
View Download 0.302 a.133.1 Phospholipase A2, PLA2
View Download 0.283 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.266 a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.241 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.229 a.142.1 PTS-regulatory domain, PRD
View Download 0.223 a.25.1 Ferritin-like
View Download 0.215 c.16.1 Lumazine synthase
View Download 0.209 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.201 d.2.1 Lysozyme-like

Predicted Domain #2
Region A:
Residues: [142-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKELCIYVHA LGFRSNLMEC EPQLLAFVDL IKKNGMTLPP QHYIIEPMEL NSYSVLPLYM  60
   61 GVDMENFKHI SRAFKTSIYA PSLITLSRDL KANPQIFFSG AVHSLSLLAR KTLRESISVN 120
  121 SKSFFYRRLT NITPGKLLFI RKYYQQKVNQ LILKYQSLIR VTNEYIEFQS ISTNLLEMVI 180
  181 KNFTIQVLHE IVEVQISLNE NCAMSPELII DSFFGHT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 6.720012207401 bayes_pls_golite062009
structural molecule activity 6.15496287636596 bayes_pls_golite062009
transcription regulator activity 3.20568770944756 bayes_pls_golite062009
RNA binding 1.82714562401326 bayes_pls_golite062009
binding 1.5466198129438 bayes_pls_golite062009
nucleic acid binding 1.48613196553259 bayes_pls_golite062009
translation initiation factor activity 1.27539679024898 bayes_pls_golite062009
DNA binding 0.99813295819535 bayes_pls_golite062009
mRNA binding 0.871057743692364 bayes_pls_golite062009
transcription termination factor activity 0.76362333646107 bayes_pls_golite062009
protein binding 0.523813050066193 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.474251377131502 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.47336621289748 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.47336621289748 bayes_pls_golite062009
transcription factor activity 0.184749183964367 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 6.9430052008157E-5 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [359-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQIVVITPK EDSFNQLIVV GNQSSTDEAS DTSILHYLSD FIMGSNQVIN PNLRQIKAIF  60
   61 EIHPDFEDFI SGKKNGKLTR IMELSACLIQ LEMEEEDDNL YLNLVSDSFP DFKESFKNVI 120
  121 NEFPAEESFF IPEVCHRPII GTGGSLIQAT MRKHNVFIQF SNSFNLPQNK ISMIRYDNVI 180
  181 IRCPRKNKAN ICLAKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1e3pA_
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
mRNA binding 4.29703395482722 bayes_pls_golite062009
nucleic acid binding 3.71927111604413 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
transcription regulator activity 1.39930706524977 bayes_pls_golite062009
DNA binding 1.19211612853211 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
mRNA 3'-UTR binding 0.496865429134247 bayes_pls_golite062009
transcription factor activity 0.272268621092333 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [555-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLKQIVQEYD SLQSKTLIRF SSGQYRHILH VNGQKNIIGQ IEKNENVYIM IPLKEPLDGT  60
   61 SQLSIQGNDE NASRAANELV NSAFGYEYEF KID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
mRNA binding 4.29703395482722 bayes_pls_golite062009
nucleic acid binding 3.71927111604413 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
transcription regulator activity 1.39930706524977 bayes_pls_golite062009
DNA binding 1.19211612853211 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
mRNA 3'-UTR binding 0.496865429134247 bayes_pls_golite062009
transcription factor activity 0.272268621092333 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [648-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEIDPNKEYE FYNLIVVPFL QIMNIIVTFE KDLITFTFEK DTNENTLTKA IELLSNYLET  60
   61 QKTKIIFKKI IKKFVLGSAS SKSNTSNSNT NGNFRSMN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.588 0.485 cytoplasm a.118.1 ARM repeat
View Download 0.728 0.240 cytoplasm a.77.1 DEATH domain
View Download 0.493 0.027 cytoplasm d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.557 0.000 cytoplasm c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.434 N/A N/A a.77.1 DEATH domain
View Download 0.424 N/A N/A a.26.1 4-helical cytokines
View Download 0.415 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.406 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.405 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.403 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.358 N/A N/A a.26.1 4-helical cytokines
View Download 0.354 N/A N/A a.26.1 4-helical cytokines
View Download 0.353 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.341 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.341 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.333 N/A N/A d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.320 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.315 N/A N/A d.58.49 YajQ-like
View Download 0.296 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.287 N/A N/A a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.281 N/A N/A d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.255 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.254 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.242 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.239 N/A N/A a.64.1 Saposin
View Download 0.238 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.230 N/A N/A c.51.3 B12-dependend dehydatases associated subunit
View Download 0.226 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.222 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.219 N/A N/A a.118.14 FliG
View Download 0.219 N/A N/A d.197.1 Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
View Download 0.212 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.208 N/A N/A a.4.1 Homeodomain-like
View Download 0.201 N/A N/A a.47.2 t-snare proteins

Predicted Domain #6
Region A:
Residues: [746-825]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAKSRTTIDN TSQSGASPQR HKMPVITTVG GAQAIKGYIP NTYYNGYGYG YGYTYEYDYN  60
   61 YANSNKAQTN NRHKYQNGRK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.718 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.699 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.690 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.687 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.683 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.639 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.569 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.551 d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.550 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.545 d.129.1 TATA-box binding protein-like
View Download 0.535 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.511 d.58.17 Metal-binding domain
View Download 0.486 b.101.1 Ribonuclease domain of colicin E3
View Download 0.484 g.41.3 Zinc beta-ribbon
View Download 0.449 d.50.1 dsRNA-binding domain-like
View Download 0.415 b.55.1 PH domain-like
View Download 0.414 b.101.1 Ribonuclease domain of colicin E3
View Download 0.410 g.41.3 Zinc beta-ribbon
View Download 0.410 g.18.1 Complement control module/SCR domain
View Download 0.402 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.394 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.394 b.1.1 Immunoglobulin
View Download 0.390 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.384 b.40.6 MOP-like
View Download 0.365 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.364 d.58.17 Metal-binding domain
View Download 0.364 b.1.1 Immunoglobulin
View Download 0.339 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.321 b.40.6 MOP-like
View Download 0.300 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.299 b.1.1 Immunoglobulin
View Download 0.295 b.1.2 Fibronectin type III
View Download 0.288 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.287 b.40.4 Nucleic acid-binding proteins
View Download 0.284 b.101.1 Ribonuclease domain of colicin E3
View Download 0.283 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.278 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.273 b.101.1 Ribonuclease domain of colicin E3
View Download 0.267 d.129.1 TATA-box binding protein-like
View Download 0.262 b.101.1 Ribonuclease domain of colicin E3
View Download 0.258 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.257 d.129.1 TATA-box binding protein-like
View Download 0.251 b.38.1 Sm-like ribonucleoproteins
View Download 0.250 g.18.1 Complement control module/SCR domain
View Download 0.249 d.9.1 Interleukin 8-like chemokines
View Download 0.240 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.236 d.93.1 SH2 domain
View Download 0.232 d.50.1 dsRNA-binding domain-like
View Download 0.226 b.38.1 Sm-like ribonucleoproteins
View Download 0.221 d.9.2 Description not found.
View Download 0.217 b.1.2 Fibronectin type III
View Download 0.213 b.55.1 PH domain-like
View Download 0.207 d.9.2 Description not found.
View Download 0.204 b.1.1 Immunoglobulin
View Download 0.201 b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle