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View Structure Prediction Details

Protein: YLL032C
Organism: Saccharomyces cerevisiae
Length: 825 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLL032C.

Description E-value Query
Range
Subject
Range
YLL032C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; ...
YL032_YEAST - KH domain-containing protein YLL032C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YLL...
0.0 [1..825] [1..825]
VIGLN_MOUSE - Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1
1.0E-70 [88..785] [296..980]
VIGLN_RAT - Vigilin OS=Rattus norvegicus GN=Hdlbp PE=1 SV=1
1.0E-70 [88..748] [296..914]
gi|157928314, gi... - gi|168278465|dbj|BAG11112.1| vigilin [synthetic construct], gi|157928314|gb|ABW03453.1| high density...
HDLBP - high density lipoprotein binding protein
3.0E-70 [91..785] [255..980]
VIGLN_CHICK - Vigilin OS=Gallus gallus GN=HDLBP PE=2 SV=1
8.0E-66 [81..785] [244..981]
gi|4972720 - gi|4972720|gb|AAD34755.1| unknown [Drosophila melanogaster]
1.0E-65 [231..747] [14..524]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNFKIYSTV ITTAFLQVPH LYTTNRLWKP IEAPFLVEFL QKRISSKELK NTKAICHIDP  60
   61 SWVNLNASFI RDDMISIKAT TDDMDLDAIC RISLPLPMNT NDLTAELEKM KRILLDLSEK 120
  121 FNLELIITKE PAYFTPEQTG E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [142-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKELCIYVHA LGFRSNLMEC EPQLLAFVDL IKKNGMTLPP QHYIIEPMEL NSYSVLPLYM  60
   61 GVDMENFKHI SRAFKTSIYA PSLITLSRDL KANPQIFFSG AVHSLSLLAR KTLRESISVN 120
  121 SKSFFYRRLT NITPGKLLFI RKYYQQKVNQ LILKYQSLIR VTNEYIEFQS ISTNLLEMVI 180
  181 KNFTIQVLHE IVEVQISLNE NCAMSPELII DSFFGHT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 6.720012207401 bayes_pls_golite062009
structural molecule activity 6.15496287636596 bayes_pls_golite062009
transcription regulator activity 3.20568770944756 bayes_pls_golite062009
RNA binding 1.82714562401326 bayes_pls_golite062009
binding 1.5466198129438 bayes_pls_golite062009
nucleic acid binding 1.48613196553259 bayes_pls_golite062009
translation initiation factor activity 1.27539679024898 bayes_pls_golite062009
DNA binding 0.99813295819535 bayes_pls_golite062009
mRNA binding 0.871057743692364 bayes_pls_golite062009
transcription termination factor activity 0.76362333646107 bayes_pls_golite062009
protein binding 0.523813050066193 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.474251377131502 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.47336621289748 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.47336621289748 bayes_pls_golite062009
transcription factor activity 0.184749183964367 bayes_pls_golite062009
catalytic activity 0.10089766806364 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 6.9430052008157E-5 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [359-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQIVVITPK EDSFNQLIVV GNQSSTDEAS DTSILHYLSD FIMGSNQVIN PNLRQIKAIF  60
   61 EIHPDFEDFI SGKKNGKLTR IMELSACLIQ LEMEEEDDNL YLNLVSDSFP DFKESFKNVI 120
  121 NEFPAEESFF IPEVCHRPII GTGGSLIQAT MRKHNVFIQF SNSFNLPQNK ISMIRYDNVI 180
  181 IRCPRKNKAN ICLAKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1e3pA_
Description: Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
mRNA binding 4.29703395482722 bayes_pls_golite062009
nucleic acid binding 3.71927111604413 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
transcription regulator activity 1.39930706524977 bayes_pls_golite062009
DNA binding 1.19211612853211 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
mRNA 3'-UTR binding 0.496865429134247 bayes_pls_golite062009
transcription factor activity 0.272268621092333 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [555-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLKQIVQEYD SLQSKTLIRF SSGQYRHILH VNGQKNIIGQ IEKNENVYIM IPLKEPLDGT  60
   61 SQLSIQGNDE NASRAANELV NSAFGYEYEF KID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.53756130039297 bayes_pls_golite062009
mRNA binding 4.29703395482722 bayes_pls_golite062009
nucleic acid binding 3.71927111604413 bayes_pls_golite062009
binding 3.03029468866374 bayes_pls_golite062009
transcription regulator activity 1.39930706524977 bayes_pls_golite062009
DNA binding 1.19211612853211 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
mRNA 3'-UTR binding 0.496865429134247 bayes_pls_golite062009
transcription factor activity 0.272268621092333 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [648-745]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEIDPNKEYE FYNLIVVPFL QIMNIIVTFE KDLITFTFEK DTNENTLTKA IELLSNYLET  60
   61 QKTKIIFKKI IKKFVLGSAS SKSNTSNSNT NGNFRSMN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [746-825]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAKSRTTIDN TSQSGASPQR HKMPVITTVG GAQAIKGYIP NTYYNGYGYG YGYTYEYDYN  60
   61 YANSNKAQTN NRHKYQNGRK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle