YRC Public Data Repository - Protein Structure Prediction

Protein:	LAS1
Organism:	Saccharomyces cerevisiae
Length:	502 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAS1.

Description	E-value	Query Range	Subject Range
LAS1_YEAST - Protein LAS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAS1 PE=1 SV=1 LAS1 - Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the ...	0.0	[1..502]	[1..502]
SPBC16C6.12c - Las1-like protein LAS1_SCHPO - Pre-rRNA-processing protein las1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=las1 PE=1...	1.0E-72	[5..228]	[4..220]
gi\|220946982, gi... - gi\|220956590\|gb\|ACL90838.1\| CG32075-PA [synthetic construct], gi\|220946982\|gb\|ACL86034.1\| CG32075-PA... FBpp0297066, CG3... - This gene is referred to in FlyBase by the symbol Dmel\CG32075 (CG32075, FBgn0052075). It is a prote...	1.0E-52	[6..200]	[41..219]
gi\|19698929, gi\|... - gi\|27311901\|gb\|AAO00916.1\| unknown protein [Arabidopsis thaliana], gi\|19698929\|gb\|AAL91200.1\| unknow...	8.0E-51	[5..166]	[29..186]
gi\|12718327 - gi\|12718327\|emb\|CAC28678.1\| related to LAS1 protein [Neurospora crassa]	2.0E-48	[32..177]	[98..279]
gi\|18676522 - gi\|18676522\|dbj\|BAB84913.1\| FLJ00158 protein [Homo sapiens]	1.0E-47	[6..160]	[59..202]

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Predicted Domain #1

Region A:
Residues: [1-23]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPPRIVPWR DFAELEELKL WFY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [43-53]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYRLKGSQYL P

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [177-361]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTGYGYRRND KLEKYMESLT KTLDKWKRLR NEFLEYKWVW ENANDSLITS SNFSGDNLVN  60
   61 YDAEKRKSSH ASSSETMIRE NLRQWQELWK LSIYHNVVLE KFFNNYDPLL LKVLMLNLNN 120
  121 FDWKVIEWVA RNYRTQQDDS NITTILKRKF NAWKELQKRL LDVIINNLNN KNFKNKWQNW 180
  181 EKLID

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.18
Match:	1n1bA
Description:	(+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [24-42]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSKGTIEDK RQRAVQRVQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [54-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVVDSTAQIT CAVLLDEKEA CLGVHQDSIP IRLSYVMALI RFVNGLLDPT QQSQFAIPLH  60
   61 TLAAKIGLPS WFVDLRHWGT HERDLPGLEM LRWAANEALS WLYDHYWNDE ELEDDRDDDD 120
  121 DDD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.18
Match:	1n1bA
Description:	(+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [362-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENASYLILYF CQSMLAKLET EKITGNSWRN KKRRKQIDST VEIEAKLKEN IDNLSLRFNE  60
   61 GEIKLYDFIP AEKDSVPLKK EVSPALKADT NDILGDLASL KQRMSSFGTV GKKNKQEENR 120
  121 ATPVKNWSRV QNWKPKPFGV L

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits