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View Structure Prediction Details

Protein: TRM2
Organism: Saccharomyces cerevisiae
Length: 617 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM2.

Description E-value Query
Range
Subject
Range
gi|9755890 - gi|9755890|emb|CAC01942.1| tRNA(m5U54)methyltransferase [Saccharomyces cerevisiae]
0.0 [71..607] [1..535]
gi|47095677, gi|... - gi|47095677|ref|ZP_00233284.1| RNA methyltransferase, TrmA family [Listeria monocytogenes str. 1/2a ...
gi|255028262 - gi|255028262|ref|ZP_05300213.1| hypothetical protein LmonL_01654 [Listeria monocytogenes LO28]
YH51_LISMO, Y175... - (Q8Y6D6) Hypothetical RNA methyltransferase lmo1751 (EC 2.1.1.-), Uncharacterized RNA methyltransfer...
gi|126941860, gi... - gi|254900744|ref|ZP_05260668.1| hypothetical protein LmonJ_13049 [Listeria monocytogenes J0161], gi|...
gi|224503324 - gi|224503324|ref|ZP_03671631.1| hypothetical protein LmonFR_12550 [Listeria monocytogenes FSL R2-561...
Y1751_LISMO - Uncharacterized RNA methyltransferase lmo1751 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BA...
gi|127765381, gi... - gi|254913771|ref|ZP_05263783.1| hypothetical protein LmonJ2_13279 [Listeria monocytogenes J2818], gi...
gi|133732615, gi... - gi|254938158|ref|ZP_05269855.1| hypothetical protein LmonF6_13559 [Listeria monocytogenes F6900], gi...
2.0E-98 [163..616] [5..433]
Y1863_LISIN - Uncharacterized RNA methyltransferase lin1863 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=...
Y1863_LISIN, YI6... - (Q92AQ7) Hypothetical RNA methyltransferase lin1863 (EC 2.1.1.-), Uncharacterized RNA methyltransfer...
2.0E-97 [163..616] [5..433]
Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans GN=BH0687 PE=3 SV=1
Y687_BACHD - Uncharacterized RNA methyltransferase BH0687 OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197...
8.0E-95 [166..616] [10..437]
YEFA_BACSU, RLMC... - Uncharacterized RNA methyltransferase yefA OS=Bacillus subtilis GN=yefA PE=3 SV=1, 23S rRNA (uracil-...
gi|221312833 - gi|221312833|ref|ZP_03594638.1| hypothetical protein BsubsN3_03754 [Bacillus subtilis subsp. subtili...
RLMCD_BACSU - 23S rRNA (uracil-C(5))-methyltransferase RlmCD OS=Bacillus subtilis (strain 168) GN=rlmCD PE=1 SV=1
gi|221317757 - gi|221317757|ref|ZP_03599051.1| hypothetical protein BsubsJ_03708 [Bacillus subtilis subsp. subtilis...
gi|221322036 - gi|221322036|ref|ZP_03603330.1| hypothetical protein BsubsS_03794 [Bacillus subtilis subsp. subtilis...
9.0E-95 [154..616] [2..438]
YAD7_SCHPO - tRNA (uracil(54)-C(5))-methyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=S...
SPAC4G8.07c - tRNA (m5U54) methyltransferase Trm2
1.0E-94 [80..606] [47..491]
gi|28925307, gi|... - gi|32413172|ref|XP_327066.1| hypothetical protein [Neurospora crassa], gi|28925307|gb|EAA34385.1| hy...
gi|85110766 - gi|85110766|ref|XP_963621.1| hypothetical protein NCU06780 [Neurospora crassa OR74A]
6.0E-92 [104..603] [79..586]
gi|19310570 - gi|19310570|gb|AAL85018.1| unknown protein [Arabidopsis thaliana]
4.0E-89 [141..605] [56..525]

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Predicted Domain #1
Region A:
Residues: [1-156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYEQFEFSFF FFENSDNKVK YKAHLISSIK RWSIITCMRC FWTVQKSIFK ARFFACRNFV  60
   61 KKHNYKLIST MTGSTEMVPP TMKHTVDNKR LSSPLTDSGN RRTKKPKLRK YKAKKVETTS 120
  121 PMGVLEFEVN DLLKSQNLSR EQVLNDVTSI LNDKSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [157-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDGPIVLQYH REVKNVKVLE ITSNGNGLAL IDNPVETEKK QVVIIPFGLP GDVVNIKVFK  60
   61 THPYYVESDL LDVVEKSPMR RDDL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 13.823909
Match: PF01938
Description: TRAM domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [241-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRDKYFGKSS GSQLEFLTYD DQLELKRKTI MNAYKFFAPR LVAEKLLPPF DTTVASPLQF  60
   61 GYRTKITPHF DMPKRKQKEL SVRPPLGFGQ KGRPQWRKDT LDIGGHGSIL DIDECVL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.221 0.243 tRNA modification a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.232 0.153 tRNA methyltransferase activity a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #4
Region A:
Residues: [358-431]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATEVLNKGLT NERRKFEQEF KNYKKGATIL LRENTTILDP SKPTLEQLTE EASRDENGDI  60
   61 SYVEVEDKKN NVRL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.398 a.4.5 "Winged helix" DNA-binding domain
View Download 0.332 a.39.1 EF-hand
View Download 0.413 a.28.1 ACP-like
View Download 0.330 a.64.1 Saposin
View Download 0.299 b.35.2 SacY-like RNA-binding domain
View Download 0.288 d.68.3 SirA-like
View Download 0.285 a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 d.26.1 FKBP-like
View Download 0.225 d.68.1 Translation initiation factor IF3, C-terminal domain

Predicted Domain #5
Region A:
Residues: [432-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKTCVTNPRQ IVTEYVDGYT FNFSAGEFFQ NNNSILPIVT KYVRDNLQAP AKGDDNKTKF  60
   61 LVDAYCGSGL FSICSSKGVD KVIGVEISAD SVSFAEKNAK ANGVENCRFI VGKAEKLFES 120
  121 IDTPSENTSV ILDPPRKGCD ELFLKQLAAY IQPRLFTYRV MSIPRHVMSS TSSKKQKTVP 180
  181 PTRLKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.045757
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle