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View Structure Prediction Details

Protein: TUL1
Organism: Saccharomyces cerevisiae
Length: 758 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TUL1.

Description E-value Query
Range
Subject
Range
TUL1_YEAST - Transmembrane E3 ubiquitin-protein ligase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
TUL1 - Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane p...
0.0 [1..758] [1..758]
gi|164426859, gi... - gi|164426859|ref|XP_961516.2| hypothetical protein NCU03740 [Neurospora crassa OR74A], gi|157071505|...
gi|16944489 - gi|16944489|emb|CAD11418.1| conserved hypothetical protein [Neurospora crassa]
2.0E-91 [177..489] [190..522]
SPBC947.10 - ubiquitin-protein ligase E3
YHSA_SCHPO - Uncharacterized RING finger protein C947.10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
4.0E-73 [313..758] [223..676]
gi|25396434, gi|... - gi|25396434|dbj|BAC24801.1| HRD1 [Homo sapiens], gi|16588806|gb|AAL26903.1|AF317634_1 HRD1 [Homo sap...
1.0E-56 [395..756] [13..334]
sel-11 - Zinc finger, C3HC4 type (RING finger) status:Confirmed UniProt:Q20798 protein_id:CAA96657.1
3.0E-56 [395..755] [14..336]
HRD1A_ARATH - ERAD-associated E3 ubiquitin-protein ligase HRD1A OS=Arabidopsis thaliana GN=HRD1A PE=2 SV=1
1.0E-52 [396..757] [14..335]
gi|7494226 - pir||T18460 hypothetical protein C0510w - malaria parasite (Plasmodium falciparum)
gi|124504903, gi... - gi|3764009|emb|CAA15602.1| RING zinc finger protein, putative [Plasmodium falciparum 3D7], gi|168052...
2.0E-51 [363..756] [498..833]

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Predicted Domain #1
Region A:
Residues: [1-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIDGNTLVF IIVILFLFFS SPGGDGVSSQ YEFNQLQRLK QQFRTEHNTF VNMTYTDSFR  60
   61 NITGLKLSYQ DMLNNPLQNA TYPLPGKDYD RWFPNQNYMV LPNDVIEAIN TEVWNTSNDD 120
  121 ASNLFPPNIT STLLGKIDLV SNNKYEKIRM PVPRFYEPAT DFSEDIPPEG ETYWSEWPSY 180
  181 GELHNVSFQH GEIAIQISHM SNLQDNNNYL RRNFINKKND RWKLLNLQID FSDKAEKEKH 240
  241 SIYSKAVYDI QRGRILSISQ SSKFHSLFAL PHYMSFQNDY NEKIFNDVKE LVDEFWNFTD 300
  301 YTDVMTMKDV QDAYNNANFK CEYLIFLQLE PWNQYTRDQI KLIDDELNWP LGRPANLSSL 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [361-597]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPINVVSGLL YSPDCGVRLG LHNVKGTRYE LKIMSIRKHL LFGIALFAAQ IYLLLTQMHH  60
   61 TNTPSMVNKI SFYCFSMINL VDGSLATLYF VAASVVPELY LPLVISAFSC FILASIFEIR 120
  121 YLISIYASQV NEQNVGIINL LRGNTGTYDE NRPRPAFIPD EGSIGGSLYG RFFFMLIIFT 180
  181 FLILSSTSWP RQLRMVFEYI LIFILNSYWI PQIFRNAVKG IPSRRERARS SIGGNRS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [598-693]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNKMPLLWSF VIGTTIIRSL PVVYVFTYSS NVFRHHKDVH FVVFLSLWLL FQISILYSQD  60
   61 VLGSRWFLPK HTIPDGYSYF KPLSNEYISE HGGGTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [694-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHTVDCAICM SDVPIYIEEI PETHKVDQHS YMVTPCNHVF HTSCLENWMN YKLQCPVCRS  60
   61 PLPPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1chc__
Description: Immediate early protein, IEEHV
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [678-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLSNEYISE HGGGTAEHTV DCAICMSDVP IYIEEIPETH KVDQHSYMVT PCNHVFHTSC  60
   61 LENWMNYKLQ CPVCRSPLPP L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1iymA
Description: EL5 RING-H2 domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.32809533104435 bayes_pls_golite062009
small conjugating protein ligase activity 5.17943669371679 bayes_pls_golite062009
acid-amino acid ligase activity 4.2482314105959 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 1.76493579130903 bayes_pls_golite062009
protein binding 1.73461977726143 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.786612602432575 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
peptidase activity 0.592030999071526 bayes_pls_golite062009
ubiquitin-specific protease activity 0.549461161056205 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.349795095432233 bayes_pls_golite062009
cysteine-type peptidase activity 0.159023519781458 bayes_pls_golite062009
hydrolase activity 0.156835837705934 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
nucleic acid binding 0.125491277540945 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle