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View Structure Prediction Details

Protein: HMS2
Organism: Saccharomyces cerevisiae
Length: 358 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMS2.

Description E-value Query
Range
Subject
Range
HMS2 - Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyp...
HMS2_YEAST - Probable transcription factor HMS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMS2 ...
0.0 [1..358] [1..358]
HSF8_SOLLC - Heat shock factor protein HSF8 OS=Solanum lycopersicum GN=HSF8 PE=3 SV=1
4.0E-67 [6..229] [33..251]
HSF1 - heat shock transcription factor 1
gi|61362382, gi|... - gi|61362386|gb|AAX42211.1| heat shock transcription factor 1 [synthetic construct], gi|61362382|gb|A...
8.0E-63 [3..227] [8..227]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
1.0E-62 [3..227] [8..227]
gi|16118447 - gi|16118447|gb|AAL12248.1| heat shock transcription factor [Phaseolus acutifolius]
1.0E-61 [2..239] [3..221]
HSF8_SOLPE - Heat shock factor protein HSF8 OS=Solanum peruvianum GN=HSF8 PE=2 SV=1
1.0E-61 [6..229] [35..253]
gi|17061849 - gi|17061849|dbj|BAB72174.1| heat shock transcription factor mutant [synthetic construct]
2.0E-61 [6..243] [14..250]
gi|17061843 - gi|17061843|dbj|BAB72171.1| heat shock transcription factor [Danio rerio]
2.0E-61 [6..243] [14..250]
HSF1_MOUSE - Heat shock factor protein 1 OS=Mus musculus GN=Hsf1 PE=1 SV=2
3.0E-61 [3..227] [8..227]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDATSRMEQP DVFVSKLYHL LQGNAYSNII QWSTDGSKLV IWNPDQFTKV ILERFFGIHT  60
   61 FAAFVKQLSK YNFQKAGRPD CVEFSNIHFQ KDNINSLSLV KAHQSAATPN VAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.124002
Match: 3htsB_
Description: Heat-shock transcription factor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.50995556050336 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
DNA binding 3.22637331076146 bayes_pls_golite062009
nucleic acid binding 3.05427098674 bayes_pls_golite062009
transcription factor activity 2.60537570879007 bayes_pls_golite062009
sequence-specific DNA binding 1.32971938164691 bayes_pls_golite062009
transcription activator activity 1.09351769815632 bayes_pls_golite062009
transcription repressor activity 0.97608021324937 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.29742933266479 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNNMNKQCTF HWDPFKVNSI LSKAIGKPSF EKLVKNVDRL QGNLDELKST NADSLRIIRE  60
   61 INASLQTISY HQFHAYQTAN FLQENFEAIK KVVCPDSCLQ HQQRQPKRPK RYSLLLLIPN 120
  121 ASELSETPLM RFAGVFEFMN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [254-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSLDTATQWH PQLHPEAYDL LFVTVSPNMQ QEHLIYFKRL RNLLPSFPVI AIINRPVSPQ  60
   61 DTSIAPSNYS RYYFHHFLQL GFSDILVSPF TPTQLITLLS KHLRT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.899 0.840 pseudohyphal growth c.47.1 Thioredoxin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle