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View Structure Prediction Details

Protein: PMT4
Organism: Saccharomyces cerevisiae
Length: 762 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PMT4.

Description E-value Query
Range
Subject
Range
PMT4 - Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to prote...
PMT4_YEAST - Dolichyl-phosphate-mannose--protein mannosyltransferase 4 OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..762] [1..762]
gi|15011522 - gi|15011522|gb|AAK77607.1|AF396953_1 protein O-mannosyl transferase [Aspergillus awamori]
0.0 [6..754] [19..734]
gi|14625800 - gi|14625800|gb|AAK71510.1| dolichyl-phosphate-mannose:protein mannosyltransferase [Emericella nidula...
gi|49095562, gi|... - gi|67537870|ref|XP_662709.1| hypothetical protein AN5105.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
0.0 [5..754] [19..733]
gi|32415215, gi|... - gi|9368945|emb|CAB99175.1| probable dolichyl-phosphate-mannose--protein mannosyltransferase [Neurosp...
gi|85079003 - gi|85079003|ref|XP_956270.1| probable dolichyl-phosphate-mannose--protein mannosyltransferase [MIPS]...
0.0 [5..755] [25..742]
POMT2 - protein-O-mannosyltransferase 2
0.0 [4..755] [16..746]
rt-PA - The gene rotated abdomen is referred to in FlyBase by the symbol Dmel\rt (CG6097, FBgn0003292). It i...
0.0 [4..755] [130..873]
PMT1_CANAL - Dolichyl-phosphate-mannose--protein mannosyltransferase 1 OS=Candida albicans (strain SC5314 / ATCC ...
PMT1_CANAL - Dolichyl-phosphate-mannose--protein mannosyltransferase 1 OS=Candida albicans GN=PMT1 PE=3 SV=1
0.0 [11..749] [11..737]

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Predicted Domain #1
Region A:
Residues: [1-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPKKRNHG KLPPSTKDVD DPSLKYTKAA PKCEQVAEHW LLQPLPEPES RYSFWVTIVT  60
   61 LLAFAARFYK IWYPKEVVFD EVHFGKFASY YLERSYFFDV HPPFAKMMIA FIGWLCGYDG 120
  121 SFKFDEIGYS YETHPAPYIA YRSFNAILGT LTVPIMFNTL KELNFRAITC AFASLLVAID 180
  181 TAHVTETRLI LLDAILIISI AATMYCYVRF YKCQLRQPFT WSWYIWLHAT GLSLSFVIST 240
  241 KYVGVMTYSA IGFAAVVNLW QLLDIKAGLS LRQFMRHFSK RLNGLVLIPF VIYLFWFWVH 300
  301 FTVLNTSGPG DAFMSAEFQE TL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 98.251812
Match: PF02366
Description: Dolichyl-phosphate-mannose-protein mannosyltransferase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [323-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDSPLSVDSK TVNYFDIITI KHQDTDAFLH SHLARYPQRY EDGRISSAGQ QVTGYTHPDF  60
   61 NNQWEVLPP

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 11.79588
Match: PF02815
Description: MIR domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [392-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGSDVGKGQA VLLNQHIRLR HVATDTYLLA HDVASPFYPT NEEITTVTLE EGDGELYPET  60
   61 LFAFQPLKKS DEGHVLKSKT VSFRLFHVDT SVALWTHNDE LLPDWGFQQQ EINGNKKVID 120
  121 PSNNWVVDEI VNLDEVRKVY IPKVVKP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.63
Match: 1n4kA
Description: IP3 receptor type 1 binding core, domain 2; IP3 receptor type 1 binding core, domain 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dolichyl-phosphate-mannose-protein mannosyltransferase activity 7.33543412640964 bayes_pls_golite062009
mannosyltransferase activity 6.32966341675541 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 2.60661923349025 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.57555885876017 bayes_pls_golite062009
receptor activity 1.99332745476324 bayes_pls_golite062009
binding 1.86366637427031 bayes_pls_golite062009
molecular transducer activity 1.71523634580131 bayes_pls_golite062009
signal transducer activity 1.71523634580131 bayes_pls_golite062009
cation channel activity 1.66500687404195 bayes_pls_golite062009
ion channel activity 1.61859406934521 bayes_pls_golite062009
substrate-specific channel activity 1.57127083095499 bayes_pls_golite062009
passive transmembrane transporter activity 1.55374970486978 bayes_pls_golite062009
channel activity 1.55374970486978 bayes_pls_golite062009
inositol-1,4,5-trisphosphate receptor activity 1.28298370923705 bayes_pls_golite062009
transferase activity 0.981084601370981 bayes_pls_golite062009
calcium channel activity 0.85901349040585 bayes_pls_golite062009
catalytic activity 0.659936859803906 bayes_pls_golite062009
calcium-release channel activity 0.65133561512386 bayes_pls_golite062009
gated channel activity 0.53737429019655 bayes_pls_golite062009
ligand-gated ion channel activity 0.52162184692236 bayes_pls_golite062009
ligand-gated channel activity 0.52162184692236 bayes_pls_golite062009
protein binding 0.405144403982597 bayes_pls_golite062009
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0.152598505509111 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [539-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPFLKKWIET QKSMFEHNNK LSSEHPFASE PYSWPGSLSG VSFWTNGDEK KQIYFIGNII  60
   61 GWWFQVISLA VFV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.563 a.4.5 "Winged helix" DNA-binding domain
View Download 0.502 a.64.1 Saposin
View Download 0.669 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.617 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.533 a.24.17 Group V grass pollen allergen
View Download 0.669 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.617 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.563 a.4.5 "Winged helix" DNA-binding domain
View Download 0.533 a.24.17 Group V grass pollen allergen
View Download 0.502 a.64.1 Saposin
View Download 0.465 a.4.1 Homeodomain-like
View Download 0.438 a.4.5 "Winged helix" DNA-binding domain
View Download 0.414 a.4.1 Homeodomain-like
View Download 0.375 g.35.1 HIPIP (high potential iron protein)
View Download 0.335 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.322 d.95.1 Glucose permease domain IIB
View Download 0.317 b.48.1 mu transposase, C-terminal domain
View Download 0.309 a.28.1 ACP-like
View Download 0.306 d.129.1 TATA-box binding protein-like
View Download 0.296 b.7.2 Periplasmic chaperone C-domain
View Download 0.295 a.156.1 S13-like H2TH domain
View Download 0.294 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.278 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.268 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.254 a.17.1 p8-MTCP1
View Download 0.247 d.129.1 TATA-box binding protein-like
View Download 0.245 a.74.1 Cyclin-like
View Download 0.243 a.30.1 ROP protein
View Download 0.240 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.233 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.232 a.74.1 Cyclin-like
View Download 0.223 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.217 d.26.1 FKBP-like
View Download 0.202 i.1.1 Ribosome and ribosomal fragments

Predicted Domain #5
Region A:
Residues: [612-762]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIIVADLITR HRGYYALNKM TREKLYGPLM FFFVSWCCHY FPFFLMARQK FLHHYLPAHL  60
   61 IACLFSGALW EVIFSDCKSL DLEKDEDISG ASYERNPKVY VKPYTVFLVC VSCAVAWFFV 120
  121 YFSPLVYGDV SLSPSEVVSR EWFDIELNFS K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle