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View Structure Prediction Details

Protein: RSF2
Organism: Saccharomyces cerevisiae
Length: 1380 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RSF2.

Description E-value Query
Range
Subject
Range
RSF2 - Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, man...
RSF2_YEAST - Respiration factor 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RSF2 PE=1 SV=1
0.0 [1..1380] [1..1380]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [326..1221] [50..979]
ZNF347 - zinc finger protein 347
gi|208968133 - gi|208968133|dbj|BAG73905.1| zinc finger protein 347 [synthetic construct]
0.0 [2..446] [315..784]
ZN252_CANLF - Zinc finger protein 252 OS=Canis lupus familiaris GN=ZNF252 PE=2 SV=1
0.0 [2..448] [398..841]
gi|15929737, gi|... - gi|21703954|ref|NP_663458.1| zinc finger protein 160 [Mus musculus], gi|15929737|gb|AAH15291.1| Zinc...
0.0 [2..446] [200..641]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPFAFGRGA PALCILTAAA RINLDNFVPC CWALFRLSFF FPLDPAYIRN ENKETRTSWI  60
   61 SIEFFFFVKH CLSQHTFFSK TLAPKRNFRA KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.144602
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [93-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKDIGDTRID RADKDFLLVP EPSMFVNGNQ SNFAKPAGQG ILPIPKKSRI IKTDKPRPFL  60
   61 CPTCTRGFVR QEHLKRHQHS HTREKPYLCI FCGRCFARRD LVLRHQQKLH 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
nucleic acid binding 4.28215395396923 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
chromatin binding 1.37132088004982 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [203-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AALVGTGDPR RMTPAPNSTS SFASKRRHSV AADDPTDLHI IKIAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.39794
Match: 2drpA_
Description: Tramtrack protein (two zinc-finger peptide)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [248-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKETILPTPK NLAGKTSEEL KEAVVALAKS NNVELPVSAP VMNDKREKTP PSKAGSLGFR  60
   61 EFKFSTKGVP VHSASS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.500 0.624 transcription factor activity a.60.1 SAM/Pointed domain
View Download 0.466 0.146 transcription factor activity a.118.8 TPR-like
View Download 0.639 0.002 transcription factor activity a.77.1 DEATH domain
View Download 0.467 0.001 transcription factor activity d.40.1 CI-2 family of serine protease inhibitors
View Download 0.495 N/A N/A a.77.1 DEATH domain
View Download 0.464 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.454 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.452 N/A N/A d.39.1 Dynein light chain 8 (DLC8)
View Download 0.450 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.413 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.387 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.366 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.364 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.352 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.348 N/A N/A a.64.1 Saposin
View Download 0.334 N/A N/A c.47.1 Thioredoxin-like
View Download 0.329 N/A N/A c.15.1 BRCT domain
View Download 0.314 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.307 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.304 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.301 N/A N/A a.28.2 Colicin E immunity proteins
View Download 0.297 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.286 N/A N/A a.4.1 Homeodomain-like
View Download 0.286 N/A N/A a.23.5 Hemolysin expression modulating protein HHA
View Download 0.254 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.245 N/A N/A c.55.4 Translational machinery components
View Download 0.241 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.239 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.233 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.222 N/A N/A d.40.1 CI-2 family of serine protease inhibitors
View Download 0.222 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.221 N/A N/A a.49.1 C-terminal domain of B transposition protein
View Download 0.220 N/A N/A a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.207 N/A N/A a.118.8 TPR-like
View Download 0.205 N/A N/A a.141.1 Frizzled cystein-rich domain

Predicted Domain #5
Region A:
Residues: [324-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAVIDRANTP SSMHKTKRHA SFSASSAMTY MSSSNSPHHS ITNFELVEDA PHQVGFSTPQ  60
   61 MTAKQLMESV SELDLPPLTL DEPPQAIKFN LNLFNNDPSG QQQQQQQQQQ NSTSSTIVNS 120
  121 NNGSTVATPG VYLLSSGPSL TDLLTMNSAH AGAGGYMSSH HSPFDLGCFS HDKPTVSEFN 180
  181 LPSSFPNTIP SNSTTASNSY SNLANQTYRQ MSNEQPLMSL SPKNPPTTVS DSSSTINFN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [563-1380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGTNNLLEPS MEPNDKDSNI DPAAIDDKWL SEFINNSDPK STFKINFNHF NDIGFIYSPP  60
   61 SSRSSIPNKS PPNHSATSLN HEKASLSPRL NLSLNGSTDL PSTPQNQLKE PSYSDPISHS 120
  121 SHKRRRDSVM MDYDLSNFFS SRQLDISKVL NGTEQNNSHV NDDVLTLSFP GETDSNATQK 180
  181 QLPVLTPSDL LSPFSVPSVS QVLFTNELRS MMLADNNIDS GAFPTTSQLN DYVTYYKEEF 240
  241 HPFFSFIHLP SIIPNMDSYP LLLSISMVGA LYGFHSTHAK VLANAASTQI RKSLKVSEKN 300
  301 PETTELWVIQ TLVLLTFYCI FNKNTAVIKG MHGQLTTIIR LLKASRLNLP LESLCQPPIE 360
  361 SDHIMEYENS PHMFSKIREQ YNAPNQMNKN YQYFVLAQSR IRTCHAVLLI SNLFSSLVGA 420
  421 DCCFHSVDLK CGVPCYKEEL YQCRNSDEWS DLLCQYKITL DSKFSLIELS NGNEAYENCL 480
  481 RFLSTGDSFF YGNARVSLST CLSLLISIHE KILIERNNAR ISNNNTNSNN IELDDIEWKM 540
  541 TSRQRIDTML KYWENLYLKN GGILTPTENS MSTINANPAM RLIIPVYLFA KMRRCLDLAH 600
  601 VIEKIWLKDW SNMNKALEEV CYDMGSLREA TEYALNMVDA WTSFFTYIKQ GKRRIFNTPV 660
  661 FATTCMFTAV LVISEYMKCV EDWARGYNAN NPNSALLDFS DRVLWLKAER ILRRLQMNLI 720
  721 PKECDVLKSY TDFLRWQDKD ALDLSALNEE QAQRAMDPNT DINETIQLIV AASLSSKCLY 780
  781 LGVQILGDAP IWPIILSFAH GLQSRAIYSV TKKRNTRI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1218-1380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNTPVFATTC MFTAVLVISE YMKCVEDWAR GYNANNPNSA LLDFSDRVLW LKAERILRRL  60
   61 QMNLIPKECD VLKSYTDFLR WQDKDALDLS ALNEEQAQRA MDPNTDINET IQLIVAASLS 120
  121 SKCLYLGVQI LGDAPIWPII LSFAHGLQSR AIYSVTKKRN TRI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle