YRC Public Data Repository - Protein Structure Prediction

Protein:	CCT5
Organism:	Saccharomyces cerevisiae
Length:	562 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCT5.

Description	E-value	Query Range	Subject Range
TCPE_YEAST - T-complex protein 1 subunit epsilon OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCT5... CCT5 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of... gi\|151945132 - gi\|151945132\|gb\|EDN63383.1\| chaperonin subunit epsilon subunit [Saccharomyces cerevisiae YJM789] gi\|207343845 - gi\|207343845\|gb\|EDZ71179.1\| YJR064Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190409540 - gi\|190409540\|gb\|EDV12805.1\| chaperonin subunit epsilon subunit [Saccharomyces cerevisiae RM11-1a]	0.0	[1..562]	[1..562]
gi\|12804225 - gi\|12804225\|gb\|AAH02971.1\|AAH02971 Unknown (protein for IMAGE:3543711) [Homo sapiens]	0.0	[16..561]	[1..538]
CH65_RHIME, CH60... - (P35471) 60 kDa chaperonin 5 (Protein Cpn60 5) (groEL protein 5), 60 kDa chaperonin 5 OS=Rhizobium m... CH605_RHIME - 60 kDa chaperonin 5 OS=Rhizobium meliloti (strain 1021) GN=groL5 PE=2 SV=2	0.0	[36..561]	[2..528]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[36..561]	[2..528]
CH602_RHILE - 60 kDa chaperonin 2 OS=Rhizobium leguminosarum GN=groL2 PE=3 SV=1	0.0	[36..561]	[2..528]
CH601_RHOSH - 60 kDa chaperonin 1 OS=Rhodobacter sphaeroides GN=groL1 PE=1 SV=4 CH601_RHOS4 - 60 kDa chaperonin 1 OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) GN=... gi\|221638732, gi... - gi\|221638732\|ref\|YP_002524994.1\| 60 kDa chaperonin 1 [Rhodobacter sphaeroides KD131], gi\|221159513\|g...	0.0	[36..560]	[2..527]
TCPE_ARATH - T-complex protein 1 subunit epsilon OS=Arabidopsis thaliana GN=CCT5 PE=1 SV=1	0.0	[18..562]	[1..535]
CH602_RHILO - 60 kDa chaperonin 2 OS=Rhizobium loti (strain MAFF303099) GN=groL2 PE=3 SV=1 CH62_RHILO, CH60... - (Q98IH9) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL protein 2), 60 kDa chaperonin 2 OS=Rhizobium l...	0.0	[36..561]	[2..528]

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Predicted Domain #1

Region A:
Residues: [1-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAARPQQPPM EMPDLSNAIV AQDEMGRPFI IVKDQGNKKR QHGLEAKKSH ILAARSVASI  60
   61 IKTSLGPRGL DKILISPDGE ITITNDGATI LSQMELDNEI AKLLVQLSKS QDDEIGDGTT 120
  121 GVVVLASALL D

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [165-441]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CDDISASNDE LFRDFLLRAA KTSLGSKIVS KDHDRFAEMA VEAVINVMDK DRKDVDFDLI  60
   61 KMQGRVGGSI SDSKLINGVI LDKDFSHPQM PKCVLPKEGS DGVKLAILTC PFEPPKPKTK 120
  121 HKLDISSVEE YQKLQTYEQD KFKEMIDDVK KAGADVVICQ WGFDDEANHL LLQNDLPAVR 180
  181 WVGGQELEHI AISTNGRIVP RFQDLSKDKL GTCSRIYEQE FGTTKDRMLI IEQSKETKTV 240
  241 TCFVRGSNKM IVDEAERALH DSLCVVRNLV KDSRVVY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [525-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFVVDPFIGK KQQILLATQL CRMILKIDNV IISGKDEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1022.0
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	2.03574683256805	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
misfolded protein binding	0.20601711041274	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [132-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QALELIQKGI HPIKIANGFD EAAKLAISKL EET

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [442-524]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGAAEVTMS LAVSEEADKQ RGIDQYAFRG FAQALDTIPM TLAENSGLDP IGTLSTLKSK  60
   61 QLKEKISNIG VDCLGYGSND MKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1022.0
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: