YRC Public Data Repository - Protein Structure Prediction

Protein:	LAA1
Organism:	Saccharomyces cerevisiae
Length:	2014 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAA1.

Description	E-value	Query Range	Subject Range
gi\|2257560 - gi\|2257560\|dbj\|BAA21452.1\| HYPOTHETICAL 229.9KD PROTEIN IN NUC1-PRP21 INTERGENIC REGION [Schizosacch...	0.0	[554..1992]	[404..1802]
LAA1_YEAST - AP-1 accessory protein LAA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAA1 PE=1 SV... LAA1 - AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endos...	0.0	[1..2014]	[1..2014]
SIP1_SCHPO - Pof6 interactor protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sip1 PE=1 SV=1 SPBC27B12.08 - AP-1 accessory protein	0.0	[554..1992]	[516..1914]
gi\|7243013 - gi\|7243013\|dbj\|BAA92554.1\| KIAA1316 protein [Homo sapiens]	0.0	[507..1683]	[25..1190]
gi\|12698169 - gi\|12698169\|dbj\|BAB21911.1\| hypothetical protein [Macaca fascicularis]	6.0E-52	[1485..1797]	[1..401]

Back

Predicted Domain #1

Region A:
Residues: [1-1286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANRSLKKVI ETSSNNGHDL LTWITTNLEK LICLKEVNDN EIQEVKEIHT QLDEFVRYIS  60
   61 VLENTDDLEL HSVFISLSQL YTISIWRLKD EYPGVVFDSA AFLTNVLCEE DVSIDDGDTD 120
  121 PNQKKKKKKS STKKKKYIYS PAKDIACTIL VQLFENFGSS ISSLIPLLFN AIFKNLKKIM 180
  181 EKSKYYHATF MTTLLQLFNA ILRNSNNDDK ILDPATYAKF SKLSKTVFDS ISTDEKDFSV 240
  241 TFVSVLIECW TAHFKQTNFI REHSHDIIET IYSRFTEGEI GVYGFANDET RIFTAKSLAE 300
  301 ILFDYYFSKN ILTLQEVWSI YVKIFLNCDT RDVESGCFES IIHLINLNLL ADNTFLSNSK 360
  361 YLDIVLSLSG VFSSYEVNNR SMNTLSRYLR YFQHMHEVIL PHLNDSAKTQ MLYYILGCSD 420
  421 TYQSSSKSDS ASNFKYSIDA KPETQWLTLL QLDFTYVLIS DLGSTFTTEE NTVKEIRDKL 480
  481 VDLATCEIFT IRVHTVEILK VFLNNCPEYL SETIENSLRA LSTDFKSTGK FIFHKNHGHA 540
  541 FIIANLIKGA ESDYISYELI MRITVFSTSF IKNNTTSTSS NLYFKGLLCW ILLIGLMNYK 600
  601 DEQYLKLQIP QLFLFWKVLL THTYTYHDED ELYKNLEIRN HALTCLLTYL SNTTIDKEMA 660
  661 KQVSYLLTKC SNFNHSIDLK SKNIDNALLH NENRILQVYL KLEKYINSDF NSSLLILIVK 720
  721 NFSDPNLYTE SSSSVLGSLK DIGNRKVSNK DDMESNIVLE SSINTLLRQN NGFAFGLSSK 780
  781 ITGDRIVNLS MSSAYKYDES ISGSWPSKDY NWYNIFEVEV SKPISPILSL DSLILLYGSG 840
  841 SYSQIDRYAP QVTTSLIDSS MELFSSVFPF LNSKIQYSIM ETLNLSMFSK MTTPLRSVAV 900
  901 AANVCSALHN ALRIMQENNL ELDYSVGQLI IESIKKIQFF NDIFLTKIKA DCVGLLTAAI 960
  961 ARTLGDEERQ KFLTEQSRIF IKNVADMDEP YLRMFHVLSL ATIFKYNSQY ANFEEYFDVI1020
 1021 FALMRDPHPV VHSWSLKAMH ILLEKHLVID LKTAALLLSS MEELLVQDKY GIYGRSTLRC1080
 1081 NYNRDFNSHV AIGEISRTLT ETVGPNFLEL NTKVLDSFRN ITLSMLISNN ILNSITSIKM1140
 1141 FENIATFKMK NILNYEIFIL ASKSIIKSSI VTGIGSSYFD TTFTGSNELI SRTSSLKGAF1200
 1201 ENFDLLTLLY KLQMEEFFMK EMENLSWRYL ALFPNSGSVK NYFTEWILHT FKRDNHWFDK1260
 1261 LYSIFNMSLG RLFQSYNRDV SALLEV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [1287-1473]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGLKKSSEKE IKGEEEESIA NVNQLTDTDA GGLDSENLQW KSRQIILNLI LMLCLESEKY  60
   61 ENLLLALSNK IADLIKISFR GSTVRNEGMK LTGLHILNFV LKNYSTMRDP QVPGSSILEQ 120
  121 QEAQITSALM PAFSKGSSPT VMSFAITVAA EVLASNIMPP DKLGRISQLL IDLLGNFKDP 180
  181 NSGIRIG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [1474-1838]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAIIVTPKAK RKIELAVLDA WAEVVQRSIT SSNDALFSFT RKYWSILVPL WIISLREYMM  60
   61 IKYNDNDSTV QVKNDSKENS LIEPRSTKIE LYEPVWLNFV EALGCTLDSD VQVILASLND 120
  121 EELEYFLFIL FSQCLEAIVK NIDDHSVKMQ VLPALHNVLK SNLCIKSIFE DDIITEVVEI 180
  181 MDRLISTGDS KEEFLLVDII SDLIIGYSKC NATPETFLQD IDKLYELLRL LMTIISERLP 240
  241 FIKYNVLTSE EDDNEIKISP TDISLLKKTF IAFESNISNF DNMFKVDLYS CLLFIIGKIY 300
  301 ECSHREVIIP IILPLFKALV KALTESEDEK NIVLLEIFYG SIKDVIYHKL DSKNKVATIL 360
  361 ILLSN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [1839-2014]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYSKLSFQEL NQCANILSEA LNNPATQPIA LQGFKRIISN IFKYPLLQYF MKLVIKRFFQ  60
   61 DIQTNDSLSQ ASIKTKLIIQ FSEEVIKQDH QKASLSIALC LSFFAAYHSA YTEKIDNEVA 120
  121 SGIVALAKLD KNSFKEAISS TISPQQKAII GSVMEAYVKS QSLGSVEEAF QLKSFD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [551-780]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESDYISYELI MRITVFSTSF IKNNTTSTSS NLYFKGLLCW ILLIGLMNYK DEQYLKLQIP  60
   61 QLFLFWKVLL THTYTYHDED ELYKNLEIRN HALTCLLTYL SNTTIDKEMA KQVSYLLTKC 120
  121 SNFNHSIDLK SKNIDNALLH NENRILQVYL KLEKYINSDF NSSLLILIVK NFSDPNLYTE 180
  181 SSSSVLGSLK DIGNRKVSNK DDMESNIVLE SSINTLLRQN NGFAFGLSSK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [781-842]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITGDRIVNLS MSSAYKYDES ISGSWPSKDY NWYNIFEVEV SKPISPILSL DSLILLYGSG  60
   61 SY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [843-1554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQIDRYAPQV TTSLIDSSME LFSSVFPFLN SKIQYSIMET LNLSMFSKMT TPLRSVAVAA  60
   61 NVCSALHNAL RIMQENNLEL DYSVGQLIIE SIKKIQFFND IFLTKIKADC VGLLTAAIAR 120
  121 TLGDEERQKF LTEQSRIFIK NVADMDEPYL RMFHVLSLAT IFKYNSQYAN FEEYFDVIFA 180
  181 LMRDPHPVVH SWSLKAMHIL LEKHLVIDLK TAALLLSSME ELLVQDKYGI YGRSTLRCNY 240
  241 NRDFNSHVAI GEISRTLTET VGPNFLELNT KVLDSFRNIT LSMLISNNIL NSITSIKMFE 300
  301 NIATFKMKNI LNYEIFILAS KSIIKSSIVT GIGSSYFDTT FTGSNELISR TSSLKGAFEN 360
  361 FDLLTLLYKL QMEEFFMKEM ENLSWRYLAL FPNSGSVKNY FTEWILHTFK RDNHWFDKLY 420
  421 SIFNMSLGRL FQSYNRDVSA LLEVNGLKKS SEKEIKGEEE ESIANVNQLT DTDAGGLDSE 480
  481 NLQWKSRQII LNLILMLCLE SEKYENLLLA LSNKIADLIK ISFRGSTVRN EGMKLTGLHI 540
  541 LNFVLKNYST MRDPQVPGSS ILEQQEAQIT SALMPAFSKG SSPTVMSFAI TVAAEVLASN 600
  601 IMPPDKLGRI SQLLIDLLGN FKDPNSGIRI GEAIIVTPKA KRKIELAVLD AWAEVVQRSI 660
  661 TSSNDALFSF TRKYWSILVP LWIISLREYM MIKYNDNDST VQVKNDSKEN SL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.19
Match:	1gw5B
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
clathrin binding	4.44172446279719	bayes_pls_golite062009
protein transporter activity	3.8871835220517	bayes_pls_golite062009
transporter activity	2.3766833486706	bayes_pls_golite062009
substrate-specific transporter activity	2.12926593993985	bayes_pls_golite062009
binding	2.08129940242136	bayes_pls_golite062009
protein binding	2.0097220759196	bayes_pls_golite062009
structural molecule activity	1.70115473462412	bayes_pls_golite062009
signal sequence binding	1.53212344797955	bayes_pls_golite062009
RNA binding	1.423416093612	bayes_pls_golite062009
transmembrane transporter activity	1.2724388835449	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.04982314606251	bayes_pls_golite062009
protein transmembrane transporter activity	0.824035252349223	bayes_pls_golite062009
active transmembrane transporter activity	0.260663498540354	bayes_pls_golite062009
ion transmembrane transporter activity	0.256036243669218	bayes_pls_golite062009
primary active transmembrane transporter activity	0.234271600707329	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.225395946682209	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.186601655036333	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.183072614802483	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.182751938544977	bayes_pls_golite062009
cytoskeletal protein binding	0.15186105020367	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.109435859778099	bayes_pls_golite062009
pyrophosphatase activity	0.0728493557966827	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0641324729536009	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0615190129942244	bayes_pls_golite062009
cation transmembrane transporter activity	0.0475280280823402	bayes_pls_golite062009

Predicted Domain #8

Region A:
Residues: [1555-1684]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEPRSTKIEL YEPVWLNFVE ALGCTLDSDV QVILASLNDE ELEYFLFILF SQCLEAIVKN  60
   61 IDDHSVKMQV LPALHNVLKS NLCIKSIFED DIITEVVEIM DRLISTGDSK EEFLLVDIIS 120
  121 DLIIGYSKCN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1685-1802]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATPETFLQDI DKLYELLRLL MTIISERLPF IKYNVLTSEE DDNEIKISPT DISLLKKTFI  60
   61 AFESNISNFD NMFKVDLYSC LLFIIGKIYE CSHREVIIPI ILPLFKALVK ALTESEDE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1803-1881]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNIVLLEIFY GSIKDVIYHK LDSKNKVATI LILLSNGYSK LSFQELNQCA NILSEALNNP  60
   61 ATQPIALQGF KRIISNIFK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #11

Region A:
Residues: [1882-2014]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPLLQYFMKL VIKRFFQDIQ TNDSLSQASI KTKLIIQFSE EVIKQDHQKA SLSIALCLSF  60
   61 FAAYHSAYTE KIDNEVASGI VALAKLDKNS FKEAISSTIS PQQKAIIGSV MEAYVKSQSL 120
  121 GSVEEAFQLK SFD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: