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View Structure Prediction Details

Protein: CCT8
Organism: Saccharomyces cerevisiae
Length: 568 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCT8.

Description E-value Query
Range		 Subject
Range
gi|18978346, gi|... - gi|18978346|ref|NP_579703.1| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi|18894178|...
 0.0 [3..549] [1..526]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2
 0.0 [3..566] [1..541]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1
THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths...
gi|473965, gi|21... - gi|473965|dbj|BAA06143.1| heat-shock protein [Pyrococcus sp.], pir||S61294 heat-shock protein - Pyro...
 0.0 [3..566] [1..541]
gi|2129425 - gi|2129425|pir||JC4270 hyperthermophilic heat shock protein - Desulfurococcus mobilis
gi|1168091 - gi|1168091|gb|AAB35235.1| hyperthermophilic heat shock protein; HHSP [Desulfurococcus]
THS_DESSY - Thermosome subunit OS=Desulfurococcus sp. (strain SY) GN=ths PE=3 SV=1
 0.0 [3..567] [1..545]
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus GN=thsB PE=3 SV=1
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 /...
 0.0 [3..548] [1..525]
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix GN=thsB PE=3 SV=2
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138...
 0.0 [1..547] [1..532]
THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=ths PE=3 SV=1
THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi GN=ths PE=3 SV=1
 0.0 [3..549] [1..526]
THSA_THEK8 - Thermosome subunit alpha OS=Thermococcus sp. (strain KS-8) GN=thsA PE=3 SV=1
 0.0 [1..566] [1..547]
gi|7441909 - gi|7441909|pir||C72512 probable thermosome, subunit APE2072 - Aeropyrum pernix (strain K1)
gi|5105771, gi|1... - gi|5105771|dbj|BAA81083.1| 555aa long hypothetical thermosome, subunit [Aeropyrum pernix K1], gi|146...
 0.0 [1..547] [8..539]
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139...
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii GN=ths PE=3 SV=1
 0.0 [3..547] [1..524]

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Predicted Domain #1
Region A:
Residues: [1-112] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLRLPQNPN AGLFKQGYNS YSNADGQIIK SIAAIRELHQ MCLTSMGPCG RNKIIVNHLG  60
   61 KIIITNDAAT MLRELDIVHP AVKVLVMATE QQKIDMGDGT NLVMILAGEL LN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [146-421] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVGEITDKND KNELLKMIKP VISSKKYGSE DILSELVSEA VSHVLPVAQQ AGEIPYFNVD  60
   61 SIRVVKIMGG SLSNSTVIKG MVFNREPEGH VKSLSEDKKH KVAVFTCPLD IANTETKGTV 120
  121 LLHNAQEMLD FSKGEEKQID AMMKEIADMG VECIVAGAGV GELALHYLNR YGILVLKVPS 180
  181 KFELRRLCRV CGATPLPRLG APTPEELGLV ETVKTMEIGG DRVTVFKQEQ GEISRTSTII 240
  241 LRGATQNNLD DIERAIDDGV AAVKGLMKPS GGKLLP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [515-568] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENIYDMLATK KFAINVATEA ATTVLSIDQI IMAKKAGGPR APQGPRPGNW DQED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 814.9897
Match: 1a6dA_
Description: Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 9.9038451294995 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 3.6934849790316 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 3.40373598585301 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 3.28982639907979 bayes_pls_golite062009
binding 3.11215702001989 bayes_pls_golite062009
protein binding 2.03574683256805 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.88769858570433 bayes_pls_golite062009
ATPase activity 1.85640607183492 bayes_pls_golite062009
pyrophosphatase activity 1.81343301131567 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.79412354283105 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.79183933227438 bayes_pls_golite062009
nucleic acid binding 1.67284737458957 bayes_pls_golite062009
DNA binding 1.60256620441721 bayes_pls_golite062009
transporter activity 1.27879339110564 bayes_pls_golite062009
transmembrane transporter activity 1.08697283907212 bayes_pls_golite062009
chaperone binding 0.91200031047441 bayes_pls_golite062009
substrate-specific transporter activity 0.828920415160435 bayes_pls_golite062009
hydrolase activity 0.577900060851977 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.573106450426516 bayes_pls_golite062009
ATPase activity, coupled 0.527748436977659 bayes_pls_golite062009
ion transmembrane transporter activity 0.280310103153739 bayes_pls_golite062009
active transmembrane transporter activity 0.275534581026027 bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism 0.26275673855778 bayes_pls_golite062009
primary active transmembrane transporter activity 0.252704226951294 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.243984617084631 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.205808843369749 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.202279803135899 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.20198255686005 bayes_pls_golite062009
transferase activity 0.18639662517366 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.16424934648837 bayes_pls_golite062009
catalytic activity 0.107125378994589 bayes_pls_golite062009
kinase activity 0.0871496920547826 bayes_pls_golite062009
cation transmembrane transporter activity 0.0778814959589007 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-145] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSEKLISMGL SAVEIIQGYN MARKFTLKEL DEM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [422-514] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAGATEIELI SRITKYGERT PGLLQLAIKQ FAVAFEVVPR TLAETAGLDV NEVLPNLYAA  60
   61 HNVTEPGAVK TDHLYKGVDI DGESDEGVKD IRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 814.9897
Match: 1a6dA_
Description: Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle